The effect of microbial composition and proteomic on improvement of functional constipation by Chrysanthemum morifolium polysaccharide

Wang, Jinmei; Liang, Qiongxin; Zhao, Qingchun; Tang, Qi; Ahmed, Adel F.; Zhang, Yan

doi:10.1016/j.fct.2021.112305

Cited by 65 publications

(30 citation statements)

References 67 publications

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“…A large number harmful microbes of Lachnospir-aceae_NK4A136 were detected in obese patient feces. 60 EPS103 decreased the relative abundance of Lachnospira- 61 Additionally, the relative abundance of Lactobacillus within the low-dose EPS103 mice was remarkably greater in contrast to that in the MC mice (p < 0.05) (Figure 5L), which suggests that the low dosage of EPS103 may potentially have the ability to improve Lactobacillus growth. Lactobacillus is a famous probiotic that is essential for maintaining healthy homeostasis.…”

Section: ■ Results and Discussionmentioning

confidence: 95%

Effects of Exopolysaccharides from Lactiplantibacillus plantarum JLAU103 on Intestinal Immune Response, Oxidative Stress, and Microbial Communities in Cyclophosphamide-Induced Immunosuppressed Mice

Gao

et al. 2022

J. Agric. Food Chem.

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This study investigated the effects of the exopolysaccharide from Lactiplantibacillus plantarum JLAU103 (EPS103) on the intestinal immune response, oxidative stress, intestinal mucosal barrier, and microbial community in cyclophosphamide-induced immune-suppressed mice. The results showed that EPS103 promoted the secretion of cytokines and the generation of secretory immunoglobulin A and mucin-2 in the small intestine of mice, which might be related to the activation of the MAPK pathway. Additionally, EPS103 protected against oxidative stress by activating antioxidation enzymes and Nrf2/Keap1 pathways. It also improved the intestinal physical barrier functions via regulating the ratio of villous height to crypt depth and upregulating the expression of tight-junction proteins. Meanwhile, EPS103 promoted the generation of short-chain fatty acids (SCFAs) and modulated the constituents of gut microbiota. These results suggested that EPS103 may modulate the intestinal immunoresponse relying on the regulation of SCFA production and gut microbiota in immunosuppressed mice, resulting in the activation of systemic immunity.

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Section: ■ Results and Discussionmentioning

confidence: 95%

Effects of Exopolysaccharides from Lactiplantibacillus plantarum JLAU103 on Intestinal Immune Response, Oxidative Stress, and Microbial Communities in Cyclophosphamide-Induced Immunosuppressed Mice

Gao

et al. 2022

J. Agric. Food Chem.

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“…The activities of Chrysanthemum polysaccharides have also attracted attention ( Wang et al, 2021b ), e.g., antioxidant, anti-inflammatory and anti-viral ( Supplementary Table S1 ), and other compounds and extracts exhibited diversified bioactivities. The antimicrobial, anti-inflammatory, anti-hypertension and antioxidant effects ( Supplementary Table S1 ) of CM have been utilized by ancient doctors and herbalists to help maintain body balance and relieve much of the sufferings.…”

Section: Pharmacological Propertiesmentioning

confidence: 99%

The genus Chrysanthemum: Phylogeny, biodiversity, phytometabolites, and chemodiversity

et al. 2022

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The ecologically and economically important genus Chrysanthemum contains around 40 species and many hybrids and cultivars. The dried capitulum of Chrysanthemum morifolium (CM) Ramat. Tzvel, i.e., Flos Chrysanthemi, is frequently used in traditional Chinese medicine (TCM) and folk medicine for at least 2,200 years. It has also been a popular tea beverage for about 2,000 years since Han Dynasty in China. However, the origin of different cultivars of CM and the phylogenetic relationship between Chrysanthemum and related Asteraceae genera are still elusive, and there is a lack of comprehensive review about the association between biodiversity and chemodiversity of Chrysanthemum. This article aims to provide a synthetic summary of the phylogeny, biodiversity, phytometabolites and chemodiversity of Chrysanthemum and related taxonomic groups, focusing on CM and its wild relatives. Based on extensive literature review and in light of the medicinal value of chrysanthemum, we give some suggestions for its relationship with some genera/species and future applications. Mining chemodiversity from biodiversity of Chrysanthemum containing subtribe Artemisiinae, as well as mining therapeutic efficacy and other utilities from chemodiversity/biodiversity, is closely related with sustainable conservation and utilization of Artemisiinae resources. There were eight main cultivars of Flos Chrysanthemi, i.e., Hangju, Boju, Gongju, Chuju, Huaiju, Jiju, Chuanju and Qiju, which differ in geographical origins and processing methods. Different CM cultivars originated from various hybridizations between multiple wild species. They mainly contained volatile oils, triterpenes, flavonoids, phenolic acids, polysaccharides, amino acids and other phytometabolites, which have the activities of antimicrobial, anti-viral, antioxidant, anti-aging, anticancer, anti-inflammatory, and closely related taxonomic groups could also be useful as food, medicine and tea. Despite some progresses, the genetic/chemical relationships among varieties, species and relevant genera have yet to be clarified; therefore, the roles of pharmacophylogeny and omics technology are highlighted.

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“…Cyclophosphamide damages the intestinal mucosa [ 114 ] and reduces the microflora; above all, it reduces the sIgA content, which is essential for intestinal homeostasis and for the balance of the immune system [ 115 ]. An increase in the content of sIgA and of the most common bacteria in the intestinal flora, Firmicutes/Bacteriodates [ 116 ], is responsible for the production of total short-chain fatty acids SCFA (acetic acid, propionic acid, butyric acid, and acid valeric). SFCAs are metabolites that may allow the normal function of the immune system to be maintained.…”

Section: Macroorganisms As Source Of Immunomodulatory Compoundsmentioning

confidence: 99%

Recent Discoveries on Marine Organism Immunomodulatory Activities

2022

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Marine organisms have been shown to be a valuable source for biologically active compounds for the prevention and treatment of cancer, inflammation, immune system diseases, and other pathologies. The advantage of studying organisms collected in the marine environment lies in their great biodiversity and in the variety of chemical structures of marine natural products. Various studies have focused on marine organism compounds with potential pharmaceutical applications, for instance, as immunomodulators, to treat cancer and immune-mediated diseases. Modulation of the immune system is defined as any change in the immune response that can result in the induction, expression, amplification, or inhibition of any phase of the immune response. Studies very often focus on the effects of marine-derived compounds on macrophages, as well as lymphocytes, by analyzing the release of mediators (cytokines) by using the immunological assay enzyme-linked immunosorbent assay (ELISA), Western blot, immunofluorescence, and real-time PCR. The main sources are fungi, bacteria, microalgae, macroalgae, sponges, mollusks, corals, and fishes. This review is focused on the marine-derived molecules discovered in the last three years as potential immunomodulatory drugs.

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The effect of microbial composition and proteomic on improvement of functional constipation by Chrysanthemum morifolium polysaccharide

Cited by 65 publications

References 67 publications

Effects of Exopolysaccharides from Lactiplantibacillus plantarum JLAU103 on Intestinal Immune Response, Oxidative Stress, and Microbial Communities in Cyclophosphamide-Induced Immunosuppressed Mice

Effects of Exopolysaccharides from Lactiplantibacillus plantarum JLAU103 on Intestinal Immune Response, Oxidative Stress, and Microbial Communities in Cyclophosphamide-Induced Immunosuppressed Mice

The genus Chrysanthemum: Phylogeny, biodiversity, phytometabolites, and chemodiversity

Recent Discoveries on Marine Organism Immunomodulatory Activities

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