The effect of naringenin on the intestinal and renal transport of organic solutes

Robinson, J. W. L.; L'Herminier, Manuel; Claudet, H. G. A.

doi:10.1007/bf00506555

Cited by 9 publications

(2 citation statements)

References 26 publications

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“…Mechanisms of action research in the 1970s extended into various tissues, leveraging data from early observations on vascular permeability and capillary function, including the eye (Varma, ), renal and intestinal tissues (Robinson, L'Herminier, & Claudet, ). Studies of vascular effects (vessel dilation) and blood pressure (BP) reduction in animal models still predominated (Petkov & Manlov, ), while emerging targets included membrane transport (Robinson et al., ), enzyme inhibition (Borchardt & Huber, ), antimicrobial activity, and impact on metal chelation and antitumor activity (Brown, ; Fujita, Nagao, Varma, & Kinoshita, ). Early studies into the activity of flavonoids focused more on enzyme activity while later works concentrated on antioxidant effects.…”

Section: Bioactivitymentioning

confidence: 99%

The Bioavailability, Transport, and Bioactivity of Dietary Flavonoids: A Review from a Historical Perspective

Williamson

Kay

Crozier

2018

Comp Rev Food Sci Food Safe

443

288

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Flavonoids are plant-derived dietary components with a substantial impact on human health. Research has expanded massively since it began in the 1930s, and the complex pathways involved in bioavailability of flavonoids in the human body are now well understood. In recent years, it has been appreciated that the gut microbiome plays a major role in flavonoid action, but much progress still needs to be made in this area. Since the first publications on the health effects of flavonoids, their action is understood to protect against various stresses, but the mechanism of action has evolved from the now debunked simple direct antioxidant hypothesis into an understanding of the complex effects on molecular targets and enzymes in specific cell types. This review traces the development of the field over the past 8 decades, and indicates the current state of the art, and how it was reached. Future recommendations based on this historical analysis are (a) to focus on key areas of flavonoid action, (b) to perform human intervention studies focusing on bioavailability and protective effects, and (c) to carry out cellular in vitro experiments using appropriate cells together with the chemical form of the flavonoid found at the site of action; this could be the native form of compounds found in the food for studies on digestion and the intestine, the conjugated metabolites found in the blood after absorption in the small intestine for studies on cells, or the chemical forms found in the blood and tissues after catabolism by the gut microbiota.

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Section: Bioactivitymentioning

confidence: 99%

The Bioavailability, Transport, and Bioactivity of Dietary Flavonoids: A Review from a Historical Perspective

Williamson

Kay

Crozier

2018

Comp Rev Food Sci Food Safe

443

288

View full text Add to dashboard Cite

show abstract

“…The mechanism of cytochrome P450 inhibition by flavonoids is not clear. As has been observed in vitro and in vivo studies of different cytochrome P450 subtypes, a non-specific direct membrane action is also possible (Robinson et al 1979).…”

Section: Discussionmentioning

confidence: 93%

Grapefruit juice inhibits 7-hydroxylation of coumarin in healthy volunteers

Merkel¹,

Sigusch

Hoffmann³

1994

Eur J Clin Pharmacol

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The effect of grapefruit juice on the urinary excretion of 7-hydroxycoumarin after oral administration of 10 mg coumarin, as an index of cytochrome P450 dependent coumarin metabolism, has been investigated in an open, randomised cross over study in 13 healthy volunteers (7 female, 6 male). The percentage of 7-hydroxycoumarin found in urine was significantly decreased up to 8 h after simultaneous intake of 300 ml grapefruit juice. If the same volume of juice was swallowed 30 min prior to the administration of coumarin, 7-hydroxycoumarin excretion was delayed by up to 6 h. MRTexcr. of coumarin was 70% extended by coadministration of grapefruit juice. It appears that grapefruit flavonoids inhibit cytochrome P450 2A dependent metabolic pathways. The mechanism of cytochrome P450 inhibition by these flavonoids is still poorly understood.

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Hypolipidaemic Effects of Naringenin, Rutin, Nicotinic Acid and Their Associations

Santos

Oliveira

Nagem

et al. 1999

Pharmacological Research

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Atherosclerosis can be defined as being a disease of coronary circulation. The present work evaluates the action of the naringenin, rutin, nicotinic acid, isolated and in association, on the metabolism of lipids. Cholesterol, cholesterol HDL, and triacylglycerols have been dosed after retreat of blood, following the administration of the compounds dissolved in propylene glycol by intraperitoneal route in doses of 5 mg kg-1 body wt. Results evidence that naringenin and nicotinic acid, isolated as well as their association with naringenin and nicotinic acid-rutin, present the largest percentual reduction of cholesterol. On the other hand, the best results for cholesterol-HDL have been obtained with naringenin, while rutin has shown the best triacylglycerols levels.

show abstract

The effect of naringenin on the intestinal and renal transport of organic solutes

Cited by 9 publications

References 26 publications

The Bioavailability, Transport, and Bioactivity of Dietary Flavonoids: A Review from a Historical Perspective

The Bioavailability, Transport, and Bioactivity of Dietary Flavonoids: A Review from a Historical Perspective

Grapefruit juice inhibits 7-hydroxylation of coumarin in healthy volunteers

Hypolipidaemic Effects of Naringenin, Rutin, Nicotinic Acid and Their Associations

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