The effect of neosurugatoxin on the release of neurohypophysial hormones by nicotine, hypotension and an osmotic stimulus in the rat

Bisset, G. W.; Fairhall, K. M.; Tsuji, Kiichiro

doi:10.1111/j.1476-5381.1992.tb14395.x

Cited by 11 publications

(14 citation statements)

References 49 publications

(49 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In each series, and in confirmation of previous work (Bisset et al, 1992), the ADR was accompanied by an increase in the excretion of AVP and OLRI. In the first series of experiments (a), two successive injections of muscarine were given at an interval of 60 min.…”

Section: Introductionsupporting

confidence: 74%

“…This is similar to the procedure which was found to be effective in previous work with nicotine and neosurugatoxin (Bisset et al, 1992 The lowest dose to produce a total and consistent inhibition was 40 nmol. Figure 3.…”

Section: Introductionmentioning

confidence: 50%

“…An antidiuretic response (ADR) was measured as the reduction in the rate of urine flow during this period expressed as a percentage of the control flow immediately preceding the injection. Full experimental details of the preparation and the extraction and the assay methods have been published (Bisset et al, 1990 (Sawyer et al, 1981) (Bisset et al, 1992). Figures 2 and 4c show that the ADR to AMPA and NMDA was accompanied by highly significant increases in the urinary rates of excretion of both AVP and OLRI.…”

Section: Introductionmentioning

confidence: 99%

“…Each rat was given two injections of muscarine and two of NMDA, one before and one after, D-AP5. D-AP5 abolished the ADR to NMDA in (Bisset et al, 1992) that HS does not induce tachyphylaxis on repeated injections. In each experiment two injections of HS were given, one as a control and the other after CNQX or D-AP5.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Release of vasopressin and oxytocin by excitatory amino acid agonists and the effect of antagonists on release by muscarine and hypertonic saline, in the rat in vivo

Bisset

Fairhall

1996

British J Pharmacology

Self Cite

View full text Add to dashboard Cite

1 It has been claimed that glutamate is the dominant excitatory neurotransmitter in neuroendocrine regulation. The evidence is derived mainly from in vitro experiments. 2 We have investigated in vivo a possible role of excitatory amino acids (EAAs) in the neural control of release of vasopressin (AVP) and oxytocin from the neurohypophysis. 3 In rats under ethanol anaesthesia in which a diuresis was maintained by a constant fluid load, the i.c.v. injection of glutamate and the synthetic agonists a-amino, 3-hydroxy-5-methyl-isoxazole-4-propionate (AMPA) and N-methyl-D-aspartate (NMDA) produced an antidiuretic response (ADR) which was abolished by an AVP antagonist. For AMPA and NMDA it was shown that this ADR was accompanied by increased urinary excretion of AVP and oxytocin. 4 The selectivity of antagonists was tested in this system. D-2-Amino-5-phosphonopentanoate (D-AP5) blocked the responses to NMDA but not to AMPA; 6-cyano-7-nitroquinoxaline-2, 3-dione (CNQX) blocked the responses to both agonists. 5 The ADR to muscarine and hypertonic saline i.c.v., and the increase in excretion of AVP and oxytocin in response to muscarine, were blocked by CNQX but not by D-AP5. 6 The results suggest that hypertonic saline releases AVP and muscarine releases both AVP and oxytocin, at least in part, by activating a glutaminergic input to the SON and PVN involving an AMPA receptor. This input could function as a terminal interneurone in afferent neural pathways to these nuclei.

show abstract

Section: Introductionsupporting

confidence: 74%

Section: Introductionmentioning

confidence: 50%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Release of vasopressin and oxytocin by excitatory amino acid agonists and the effect of antagonists on release by muscarine and hypertonic saline, in the rat in vivo

Bisset

Fairhall

1996

British J Pharmacology

Self Cite

View full text Add to dashboard Cite

show abstract

“…This effect on osmotic pressure was similar to those induced by ACh, NA and opioids (13)(14)(15)(16)(17)(18). The increase in urine AVP level prob ably reflects an increase in plasma AVP level (24,33). The urine AVP level can be measured by radioimmunoassay without prior extraction.…”

Section: Discussionmentioning

confidence: 93%

Blockade of Retinal NMDA Receptors by Sodium Nitroprusside Is Probably Due to Nitric Oxide Formation

Ujihara

Akaike

Tsutsumi

et al. 1993

Japanese Journal of Pharmacology

View full text Add to dashboard Cite

ABSTRACT-The effects of injection of substance P (SP) into the hypothalamic supraoptic vasopres sinergic nucleus (SON) in water-loaded and ethanol-anesthetized rats were examined. Keywords:Substance P, Antidiuresis, Supraoptic nucleus, Vasopressin, Substance P antagonist Substance P (SP), a member of the tachykinin family of bioactive peptides, is suggested to be a neurotransmit ter or a neuromodulator in the central and peripheral nervous system (1 3). Immunohistochemical studies have shown that SP terminals are found not only in the spinal cord (4) and the substantia nigra (5), but also in the hypothalamus (6, 7). Therefore, the involvement of SP in physiological functions in the hypothalamus such as stimulation of arginine-vasopressin (AVP), growth hor mone and prolactin release has been suggested (8 10).The hypothalamic supraoptic nucleus (SON), as well as the paraventricular nucleus (PVN), contains cell bodies of vasopressinergic neurons that synthesize and release AVP. Stimulation of vasopressinergic neurons by neuro transmitters and neuromodulators induces a release of AVP, eventually causing antidiuresis through the renal AVP (V2) receptors (11,12). By injecting various drugs into the SON or PVN, we have previously shown that cholinergic (13,14), adrenergic (15, 16) and enkephaliner gic mechanisms (17, 18) may control the urine outflow through a stimulation of AVP release.The vasopressinergic cell bodies in the SON or PVN make synaptic contact with SP-containing nerve termi nals (6). It was demonstrated that intraventricular injec tion of SP induced a prolonged antidiuresis in water-load ed rat (19) and an increase in firing frequency of the SON (20). However, the effect of SP microinjected directly into the vasopressinergic nuclei on the AVP release remains un clear. In this study, we examined the effects of SP and its analog [D-Pro2, D-Trp'°9]SP on the outflow, osmotic pres sure and AVP level of urine by injection into the SON in water-loaded and ethanol-anesthetized rats. The influ ences of pretreatments with AVP-receptor, SP-receptor and muscarinic receptor antagonists on the SP-induced antidiuresis were also examined. The present data showed that SP causes antidiuresis through the release of AVP. MATERIALS AND METHODS Animals and drugsMale Wistar rats, weighing 280-330 g, were used.

show abstract

Epibatidine: high potency and broad spectrum activity on neuronal and neuromuscular nicotinic acetylcholine receptors

Lembeck

1999

Naunyn-Schmiedeberg's Arch Pharmacol

View full text Add to dashboard Cite

The activity of epibatidine at neuronal and neuromuscular nicotinic acetylcholine receptors was investigated in several in situ and in vitro systems and compared with the activity of nicotine and suxamethonium. Activation of ganglionic nicotinic receptors by epibatidine was shown in the guinea-pig ileum (contraction mediated by the cholinergic neurons of the ileum) and in pithed and atropinized rats (rise in blood pressure). Epibatidine also activated nicotinic receptors at the peripheral terminals of afferent C-fibres (rabbit ear) and in the brain (antidiuresis in rats). The agonistic effects of epibatidine were followed by long-lasting receptor desensitization. No antinociceptive effect of epibatidine was seen in rats at a dose free of motor impairment. On muscle end plate nicotinic receptors of the rat diaphragm (not responding to depolarizing agents by contraction), epibatidine was equipotent with suxamethonium in causing neuromuscular inhibition. On an extraocular muscle of the rabbit (responding to depolarizing agents by contraction) epibatidine in vitro and in situ caused a contraction at a 100-fold lower dose than suxamethonium. The Straub tail reaction in mice to epibatidine could be attributed to the sustained stimulation of motor end plate receptors of the "slow contracting" type of muscle fibres by epibatidine. In conclusion epibatidine was the most potent agonist on all neuronal and neuromuscular nicotinic receptors examined.

show abstract

The effect of neosurugatoxin on the release of neurohypophysial hormones by nicotine, hypotension and an osmotic stimulus in the rat

Cited by 11 publications

References 49 publications

Release of vasopressin and oxytocin by excitatory amino acid agonists and the effect of antagonists on release by muscarine and hypertonic saline, in the rat in vivo

Release of vasopressin and oxytocin by excitatory amino acid agonists and the effect of antagonists on release by muscarine and hypertonic saline, in the rat in vivo

Blockade of Retinal NMDA Receptors by Sodium Nitroprusside Is Probably Due to Nitric Oxide Formation

Epibatidine: high potency and broad spectrum activity on neuronal and neuromuscular nicotinic acetylcholine receptors

Contact Info

Product

Resources

About