The effect of neuro‐ and adenohypophysectomy on retrograde degeneration in hypothalamic nuclei of the rat

Bodian, David; Maren, Thomas H.

doi:10.1002/cne.900940310

Cited by 80 publications

(16 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Simple calculations based on the fact that the SO and PV nuclei contain about 14,000 and 4000 cells in the rat, respectively (Bodian & Maren, 1951;Bandaranayake, 1971), and that 48 % of the SO units and 58 % of the PV units accelerate before each milk ejection suggests that the release of oxytocin favours the SO nucleus by a factor of 3: 1. This conclusion is D. W. LINCOLN AND J.…”

Section: Background Activity Of So Units During Sucklingmentioning

confidence: 99%

Electrophysiological evidence for the activation of supraoptic neurones during the release of oxytocin

Lincoln¹,

Wakerley²

1974

The Journal of Physiology

258

124

View full text Add to dashboard Cite

SUMMARY1. Antidromically identified supraoptic (SO) units were recorded in lactating rats anaesthetized with urethane (1.1 g/kg), and their activity was studied during milk ejection evoked by the suckling of the young. Fifty-eight SO units were recorded through 174 milk ejections. Each milk ejection was the result of a neurohypophysial release of an oxytocin pulse of 0.5-1-5 m-u.2. Fifty-five of the SO units displayed background activity and three were silent. The firing rates ranged from 0 to 15-4 spikes/sec, the distribution was exponential with 26 % of the units firing at < 1 spike/sec. Sixteen (28 %) of the SO units displayed a phasic pattern of activity characterized by periods of activity (6-132 sec) and silence (4-71 sec).3. Twenty-five of the non-phasic units displayed a large and stereotyped acceleration in spike activity some 10-5-17-4 see before the rise in intramammary pressure at milk ejection. Units accelerated to rates between 9-66 spikes/sec, an increase of about thirtyfold (median) on background activity. The response was brief (0.9-4.7 see) and was followed by a period of after-inhibition.4. It was concluded from studies of double recordings and observations of multi-unit activity that all the responsive units were synchronously activated. The mean latency of 13-3 sec between the onset of the neurosecretory response and milk ejection was similar to that observed following the experimental release of endogenous oxytocin by electrical stimulation of the neurohypophysis (50 pulses/sec for 2-4 sec).5. Four of the phasically active units were correlated with the oxytocin release for milk ejection. Three of these units displayed a burst of activity superimposed on the terminal portion ofan active phase, some 10 2-14*7 see

show abstract

Section: Background Activity Of So Units During Sucklingmentioning

confidence: 99%

Electrophysiological evidence for the activation of supraoptic neurones during the release of oxytocin

Lincoln¹,

Wakerley²

1974

The Journal of Physiology

258

124

View full text Add to dashboard Cite

show abstract

“…The supraoptic nucleus as discussed here refers only to the principal part of the SON described by Bodian and Maren [3]. The retrochiasmatic part of the SON is classi fied with the accessory neurosecretory nuclei (fig.…”

Section: The Sonmentioning

confidence: 99%

Comparative Distribution of Vasopressin and Oxytocin Neurons in the Rat Brain Using a Double-Label Procedure

Hou-Yu

Lamme

Zimmerman³

et al. 1986

Neuroendocrinology

157

View full text Add to dashboard Cite

The distribution of vasopressin (VP) and oxytocin (OT) neurons in the rat supraoptic (SON), paraventricular (PVN), and accessory magnocellular (AMN) nuclei was studied by localizing both peptides on the same section with a double immunocytochemical staining procedure employing specific monoclonal antibodies (MAB). This procedure allows us to visualize the distribution of one cell type relative to the other. In the rostral SON, VP cells lie dorsal and medial to the OT cells. Near the mid-point of the nucleus along its rostral-caudal length, there is a transition zone in which the two cell types are mixed. Proceeding caudalward, the relative locations of OT and VP cells are exchanged so that most of VP cells are located in the ventral and medial sector of the nucleus, whereas the OT cells are situated dorsal and lateral. However, there is no absolute segregation of the two types of cells anywhere in the nucleus. In the anterior part of the PVN a rostral group (rPVN) of cells composed of a medial portion and a lateral wing can be recognized. Nearly all of the cells in the rPVN are oxytocin-containing. The rPVN is separated from the next group, the middle PVN (mPVN), by a cell poor zone of about 100–150 µm. The mPVN contains both OT and VP neurons. As one proceeds caudally, the OT cells extend in the rostrocaudal direction from an anterior and ventromedial location, forming a shell around a core of VP neurons. In the most caudal PVN (cPVN), a triangular cell group characterized by fusiform cells with long-beaded processes can be distinguished from the more rounded cells of the remaining PVN. Many fusiform cells in the cPVN appear to send their axons to the posterior perifornical nucleus and the nucleus of the medial forebrain bundle. Other fusiform cells of the cPVN are oriented in a rostral-caudal plane and are situated more medially in this subdivision. The dendrites of these cells project into the mPVN while their posterior processes, most of which also appear to be dendrites, project caudally along a medial route.

show abstract

“…Each nucleus is, in turn, made up of another two parts: the principal one (BANDARANAYAKE,1971;RHODES et al, 1981) consisting of more than 80% of the whole number of the neurons and corresponding to CAJAL's nucleus tangentialis (NAUTA and HAYMAKER, 1969); and the other part just under the principal one, being variously considered: by SZENTAGOTHAI et al (1962) as the accessory nucleus, as the nucleus tuberalis by BoDIAN and MAREN (1951), and as the diffuse supraoptic nucleus by NAUTA and HAYMAKER (1969). In the present paper, only the principal part of the SON will be considered.…”

Section: Discussionmentioning

confidence: 99%

Topographical development of the supraoptic nucleus of the rat.

Lazcano

Bentura

Carrato

1988

Archives of Histology and Cytology

View full text Add to dashboard Cite

The effect of neuro‐ and adenohypophysectomy on retrograde degeneration in hypothalamic nuclei of the rat

Cited by 80 publications

References 22 publications

Electrophysiological evidence for the activation of supraoptic neurones during the release of oxytocin

Electrophysiological evidence for the activation of supraoptic neurones during the release of oxytocin

Comparative Distribution of Vasopressin and Oxytocin Neurons in the Rat Brain Using a Double-Label Procedure

Topographical development of the supraoptic nucleus of the rat.

Contact Info

Product

Resources

About