The effect of peritoneal fluid from patients with endometriosis on human sperm function in vitro

Direct effect of macrophage migration inhibitory factor on sperm function: possible involvement in endometriosis-associated infertility

“…The literature contains contradicting data about the effects of peritoneal fluid of patients with endometriosis on human sperm function. While some studies showed no significant effects (37), other studies showed significant impairment of sperm function and motion (5,(38)(39)(40) and interference with sperm-egg interaction in vitro (41,42). Negative effects of peritoneal macrophages from women with endometriosis on sperm functions were also reported (43).…”

Endometriosis and Angiogenic Factors

“…), and ovum capture by tubal fimbriae (Suginami et al, 1988) have been studied. Aeby et al (Aeby et al,1996), using a penetration assay, showed that peritoneal fluid from patients with endometriosis impaired gamete interaction. In their study, the mean number of eggs penetrated by sperm mixed with peritoneal fluid from patients with endometriosis was significantly less than that observed in controls.…”

L'insémination tubaire chez la femme a-t-elle un avenir ?

“…Aucune explication n'est donnée par les auteurs, concernant les mauvais résultats après FSP en cas d'endométriose. Il est possible que chez des patientes atteintes d'endométriose, le liquide péritonéal ait des effets toxiques sur les spermatozoïdes, notamment sur leur mobilité et leur aptitude à la réaction acrosomique et à la fécondation [49,50]. Cependant, cette notion reste actuellement très controversée [51][52][53].…”