The Effect of Phototherapy on Expression of Bax and Bcl2 Genes in Neonates with Jaundice

Abstract

Introduction: Electrical injury (EI) can be defined as damage caused by generated electrical current passing through the body. Electrical injuries are an emerging health problem in developing countries due to the widespread use of electrical appliances with lack of awareness regarding safety issues among the general population. Aim of the work: The aim of this study is to detect histopathological changes in testes and to evaluate the expression of Caspase-3 in testes of electrically injured rats by non-fatal electrical current. Material and Methods: This work was done in forensic medicine and clinical toxicology department, faculty of medicine, Minia University. This study included 60 male albino rats with average weight 200-250 gm were used. This study was done to detect histopathological changes in testes and to evaluate the expression of Caspase 3 in testes of electrically injured rats by non-fatal electrical current. All animals were given free access to standard pellet chow and water prior to the experiments. All procedures were approved by the Ethical Committee of Minia University. Results: there were signicant histopathological changes in testes of the experimental animals as well as significant increase in the expression of caspase 3 among experimental groups. Conclusion: the main pathogenesis of electrical injury on testes was apoptosis and confirmed by histipathological changes and elevated caspase 3 level.