The effect of pine resin on chromosome breakage and sister-chromatid exchanges in human peripheral lymphocytes

Athanasiou, Kyriakos; Bartsocas, Christos S.

doi:10.1016/0165-1218(80)90150-0

Cited by 7 publications

(1 citation statement)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Negative results with abietic acid were obtained in a test for differential killing in a DNA‐polymerase‐deficient Escherichia coli strain (no other details; Domanski, 1989 ). Pine resin (‘retsina’), containing abietic acid as main component, did not induce sister chromatid exchanges and chromosomal aberrations in human lymphocyte cultures (Athanasiou and Bartsocas, 1980 , as referenced in MAK Value Documentation, 2013 ).…”

Section: Assessmentmentioning

confidence: 99%

Safety and efficacy of a feed additive consisting of a tincture derived from the buds of Pinus sylvestris L. (pine tincture) for use in all animal species (FEFANA abl)

Bampidis,

Azimonti,

Bastos

et al. 2023

EFS2

View full text Add to dashboard Cite

Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of a tincture from the buds of Pinus sylvestris L. (pine tincture) when used as a sensory additive in feed and water for drinking for all animal species. The product under assessment is a solution, with a dry matter content of ~2.2%. The product contains on average 0.0882% polyphenols, of which 0.0222% are phenolic acids. The Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) concluded that pine tincture is safe at the maximum proposed use level of 50 mg/kg complete feed for all animal species. The FEEDAP Panel considers that the use in water for drinking alone or in combination with use in feed should not exceed the daily amount that is considered safe when consumed via feed alone. No safety concern would arise for the consumer from the use of pine tincture up to the maximum proposed use level in feed. Pine tincture should be considered as irritant to skin and eyes, and as a dermal and respiratory sensitiser. The use of pine tincture in animal feed was not expected to pose a risk for the environment. Since twigs of P. sylvestris, which are considered similar in composition to the source material for the production of pine tincture, are described to flavour food, no further demonstration of efficacy is deemed necessary.

show abstract

Section: Assessmentmentioning

confidence: 99%

Safety and efficacy of a feed additive consisting of a tincture derived from the buds of Pinus sylvestris L. (pine tincture) for use in all animal species (FEFANA abl)

Bampidis,

Azimonti,

Bastos

et al. 2023

EFS2

View full text Add to dashboard Cite

show abstract

Abietinsäure [MAK Value Documentation in German language, 2002]

2012

The MAK‐Collection for Occupational Health and Safety

View full text Add to dashboard Cite

Veröffentlicht in der Reihe Gesundheitsschädliche Arbeitsstoffe , 34. Lieferung, Ausgabe 2002 Der Artikel enthält folgende Kapitel: Allgemeiner Wirkungscharakter Wirkungsmechanismus Toxikokinetik und Metabolismus Erfahrungen beim Menschen Einmalige Exposition Wiederholte Exposition Wirkung auf Haut und Schleimhäute Allergene Wirkung Tierexperimentelle Befunde und In‐vitro‐Untersuchungen Akute Toxizität Subakute, subchronische und chronische Toxizität Wirkung auf Haut und Schleimhäute Allergene Wirkung Reproduktionstoxizität Genotoxizität Kanzerogenität Sonstige Wirkungen Bewertung

show abstract

Abietic acid [MAK Value Documentation, 2013]

2013

The MAK‐Collection for Occupational Health and Safety

View full text Add to dashboard Cite

Published in the series MAK Value Documentations The article contains sections titled: Toxic Effects and Mode of Action Mechanism of Action Toxicokinetics and Metabolism Effects in Humans Single exposures Repeated exposures Local effects on skin and mucous membranes Allergenic effects Animal experiments and in vitro studies Acute toxicity Subacute, subchronic and chronic toxicity Effects on skin and mucous membranes Allergenic effects Reproductive and developmental toxicity Genotoxicity Carcinogenicity Other effects Manifesto (MAK value, classification)

show abstract

The effect of pine resin on chromosome breakage and sister-chromatid exchanges in human peripheral lymphocytes

Cited by 7 publications

References 6 publications

Safety and efficacy of a feed additive consisting of a tincture derived from the buds of Pinus sylvestris L. (pine tincture) for use in all animal species (FEFANA abl)

Safety and efficacy of a feed additive consisting of a tincture derived from the buds of Pinus sylvestris L. (pine tincture) for use in all animal species (FEFANA abl)

Abietinsäure [MAK Value Documentation in German language, 2002]

Abietic acid [MAK Value Documentation, 2013]

Contact Info

Product

Resources

About