The effect of propofol when injected at different speeds for induction of general anesthesia: an observational study

Rather, Zahid Mohd; Rather, Mohd Nazrull islam; Afaq, Barqul; Farooq, Umar; Majid, Nighat Ara

doi:10.18203/2349-3259.ijct20181741

Cited by 4 publications

(2 citation statements)

References 11 publications

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“…Propofol, which was used for induction of anaesthesia in combination with midazolam, can reduce SVR and blood pressure because of a decrease in sympathetic activity, direct vasodilatation and myocardial depression 15 21–23. Nevertheless, the vasodilation seems to be dependent on the dose administered and the rate of its administration 24 25. It is also known that the coadministration of a sedative drug, like a benzodiazepine, during induction, decreases the dose of propofol required, and therefore the related cardiopulmonary depression 26 27…”

Section: Discussionmentioning

confidence: 99%

Anaesthetic management of a patent ductus arteriosus (PDA) occlusion using an Amplatz canine duct occluder (ACDO) in a dog

Binetti¹,

Smets²,

Bosmans³

et al. 2020

Vet Record Case Reports

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Patent ductus arteriosus (PDA) is one of the most common diagnosed congenital disease in dogs that usually causes heart failure and death unless corrected at a young age. A 2.5-year-old female intact Coton de Tuléar was referred and diagnosed with a left to right shunt PDA. Closure of the PDA was performed via a minimally invasive approach by means of an Amplatz canine duct occluder device. In this case report, we describe a successful anaesthetic protocol that included premedication using a combination of acepromazine and methadone, induction with propofol and midazolam and maintenance with isoflurane in oxygen, as well as a lidocaine constant rate constant rate infusion for intraoperative analgesic and cardiovascular support. This protocol provided excellent intraoperative cardiopulmonary stability and a smooth and rapid recovery.

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Section: Discussionmentioning

confidence: 99%

Anaesthetic management of a patent ductus arteriosus (PDA) occlusion using an Amplatz canine duct occluder (ACDO) in a dog

Binetti¹,

Smets²,

Bosmans³

et al. 2020

Vet Record Case Reports

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“… 9 Conversely, TCI ensures a gradual and consistent attainment of the therapeutic target. Despite a multitude of studies 3 , 9 , 10 , 11 comparing different propofol administration techniques, the existing evidence is characterized either by its low quality or by conflicting results.…”

Section: Introductionmentioning

confidence: 99%

Comparison of arterial hypotension incidence during general anesthesia induction – target-controlled infusion vs. bolus injection of propofol: a randomized clinical trial

Vale,

Govêia,

Guimarães

et al. 2024

Brazilian Journal of Anesthesiology (English Edition)

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Bioelectrical impedance analysis of body composition for the anesthetic induction dose of propofol in older patients

et al. 2019

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Background Older people are currently the fastest growing segment of the worldwide population. The present study aimed to estimate propofol dose in older patients based on size descriptors measured by bioelectrical impedance analysis (BIA). Methods A cross sectional study in adult and older patients with body mass index equal to or lower than 35 kg/m2 was carried out. BIA and Clinical Frail Scale scoring were performed during pre-operative evaluation. Propofol infusion was started at 2000 mg/h until loss of consciousness (LOC) which was defined by “loss of eye-lash reflex” and “loss of response to name calling”. Total dose of propofol at LOC was recorded. Propofol plasma concentration was measured using gas chromatography/ion trap-mass spectrometry. Results Forty patients were enrolled in the study. Total propofol dose required to LOC was lower in Age ≥ 65 group and a higher plasma propofol concentration was measured in this group. 60% of old patients were classified as “apparently vulnerable” or “frail” and narrow phase angle values were associated with increasing vulnerability scores. In the Age ≥ 65 group, the correlation analysis showed that the relationship between propofol dose and total body weight (TBW) scaled by the corresponding phase angle value is stronger than the correlation between propofol dose and TBW or fat free mass (FFM). Conclusions This study demonstrates that weight-based reduction of propofol is suitable in older patients; however FFM was not seen to be more effective than TBW to predict the propofol induction dose in these patients. Guiding propofol induction dose according to baseline frailty score should also be considered to estimate individualized dosage profiles. Determination of phase angle value appears to be an easy and reliable tool to assess frailty in older patients. Trial registration ClinicalTrials.gov Identifier: NCT02713698. Registered on 23 February 2016.

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The effect of propofol when injected at different speeds for induction of general anesthesia: an observational study

Cited by 4 publications

References 11 publications

Anaesthetic management of a patent ductus arteriosus (PDA) occlusion using an Amplatz canine duct occluder (ACDO) in a dog

Anaesthetic management of a patent ductus arteriosus (PDA) occlusion using an Amplatz canine duct occluder (ACDO) in a dog

Comparison of arterial hypotension incidence during general anesthesia induction – target-controlled infusion vs. bolus injection of propofol: a randomized clinical trial

Bioelectrical impedance analysis of body composition for the anesthetic induction dose of propofol in older patients

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