The effect of proton pump inhibitors on fracture risk: report from the Canadian Multicenter Osteoporosis Study

La, Fraser; Leslie, William D.; Targownik, Laura E.; Παπαϊωάννου, Αλεξάνδρα; Adachi, Jonathan D.

doi:10.1007/s00198-012-2112-9

Cited by 120 publications

(80 citation statements)

References 43 publications

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“…In sensitivity analysis, for participants who interrupted drug use during a given 5-year period, time-dependent exposure was defined as a variable [12] whose time-dependent value gradually decreased from initial value of 1 (in the first year of the period) to 0 in the last year, in equal steps of 0.2 reduction for each additional year. For example, a participant who reported use in year 0 but no use in year 5 was assigned values of 0.8, 0.6, 0.4, and 0.2, respectively, for years 1-4.…”

Section: Drug Use Assessment and Modelingmentioning

confidence: 99%

Antidepressant use and 10-year incident fracture risk: the population-based Canadian Multicentre Osteoporosis Study (CaMoS)

et al. 2014

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Summary-We used data from a large, prospective Canadian cohort to assess the association between selective serotonin reuptake inhibitors (SSRIs) and serotonin and noradrenaline reuptake inhibitors (SNRIs) and fracture. We found an increased risk of fractures in individuals who used SSRI or SNRI, even after controlling for multiple risk factors.Introduction-Previous studies have suggested an association between SSRIs and increasing risk of fragility fractures. However, the majority of these studies were not long-term analyses or were performed using administrative data and, thus, could not fully control for potential confounders. We sought to determine whether the use of SSRIs and SNRIs is associated with increased risk of fragility fracture, in adults aged 50+.

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Section: Drug Use Assessment and Modelingmentioning

confidence: 99%

Antidepressant use and 10-year incident fracture risk: the population-based Canadian Multicentre Osteoporosis Study (CaMoS)

et al. 2014

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“…5C). There have also been reports showing that some drugs (e.g., steroids, TZD, and PPIs) and comorbidities (e.g., SLE, RA, DM or CKD) are associated with the occurrence of insufficiency fractures [10][11][12]. These factors are also considered to be involved in the development of AFF.…”

Section: Discussionmentioning

confidence: 99%

Study of Atypical Femoral Fracture Cases Coupled in a Multicenter Study

Zenke

Ikeda

Fukuda³

et al. 2016

J UOEH

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: There are several causes of atypical femoral fractures (AFF) in elderly Japanese patients, including longterm bisphosphonate (BP) use or bowed femoral shaft stress fractures, but the available sample size for examining AFF etiology in a single institution is limited. The purpose of this study was to categorize the characteristics of AFF by analyzing the data compiled on patients treated at our hospital and at affiliated institutes. This multicenter, retrospective, observational study included 34 AFF cases (bilateral AFF 10) in one male and 23 female patients (age range 30-90 years, mean age 73.0 years). Evaluation measures included the presence/absence of BP use, duration of BP use, history of other drug use, presence/absence of comorbidities, fracture site, presence/absence of femoral lateral bowing, bone biopsy parameters, and time to bone union. Nineteen patients were prescribed BP for osteoporosis (duration range 4-10 years, mean duration 6.1 years). Subtrochanteric and femoral shaft fractures were seen in 16 and 18 cases, respectively (complete fractures 22, incomplete fractures 12). Femoral lateral bowing (n = 16) occurred with femoral shaft fractures. Mean time to bone union was 9.0 months (complete fractures 11.3 months, incomplete fractures 3.7 months). AFF could be substantially caused by three factors: BP use, drugs other than BP/ comorbidity, and femoral lateral bowing. Twenty four patients were classified as having BP-related-type (n = 2), drug/comorbidity-type (n = 3), lateral bowing-type (n = 2), or mixed-type (n = 17) AFF. AFF etiology cannot be explained by a single cause; thus, a multifactorial etiology, including poor bone quality due to mutual interactions and mechanical stress, seems to be responsible for the occurrence of AFF. Level of evidence: Ⅳ diagnostic

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“…The discontinuance of PPIs in many cases causes the patients to be affected by increased acid secretion and recurrence of symptoms (14,15). hip fractures (18), reduced absorption of nutrients such as calcium and magnesium (19), kidney problems (20), and dementia (21). Therefore, if we could reduce the reversibility and duration of PPI treatment, we hope to successfully treat reflux.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Myrtus communis L. Syrup in Reducing the Recurrence of Gastroesophageal Reflux Disease: A Double-Blind Randomized Controlled Trial

Salehi

Azizkhani

Mobli

et al. 2017

Iran Red Crescent Med J

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The effect of proton pump inhibitors on fracture risk: report from the Canadian Multicenter Osteoporosis Study

Cited by 120 publications

References 43 publications

Antidepressant use and 10-year incident fracture risk: the population-based Canadian Multicentre Osteoporosis Study (CaMoS)

Antidepressant use and 10-year incident fracture risk: the population-based Canadian Multicentre Osteoporosis Study (CaMoS)

Study of Atypical Femoral Fracture Cases Coupled in a Multicenter Study

The Effect of Myrtus communis L. Syrup in Reducing the Recurrence of Gastroesophageal Reflux Disease: A Double-Blind Randomized Controlled Trial

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