The effect of Pycnogenol on fluoride induced rat kidney lysosomal damage <i>in vitro</i>

Arhima, Mahmud H; Gulati, O. P.; Sharma, Sapneh

doi:10.1002/ptr.1395

Cited by 30 publications

(8 citation statements)

References 26 publications

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“…Eventually, the system of pure ethanol solution was selected to study the fluorescence response of 1 with F – in detail. As shown in Figure a, compared to other anions examined, only F – caused a remarkable fluorescence increase at 510 nm, and a similar result was observed by addition of a NaF solution. All competitive anions had no obvious interference with the detection of F – (Figure b).…”

Section: Resultssupporting

confidence: 75%

A Selective, Sensitive, Colorimetric, and Fluorescence Probe for Relay Recognition of Fluoride and Cu(II) Ions with “Off–On–Off” Switching in Ethanol–Water Solution

et al. 2012

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Anion to cation relay recognition was designed and realized for the first time with sequence specificity (F(-)→Cu(2+)) via a fluorescence "off-on-off" mechanism. Probe 1 was a highly selective, sensitive, and turn-on chemodosimeter for F(-) through a specific cyclization reaction triggered by the strong affinity of fluoride toward silicon with a significant change of fluorescence color in both ethanol and ethanol-water (1:1, v/v) solution. Fluorescence enhancement factors were dramatic: 833-fold in ethanol and 164-fold in ethanol-water (1:1, v/v) solution, respectively. The in situ system generated from the sensing of F(-) showed good relay recognition ability for Cu(2+) via fast fluorescence quenching by the formation of a 1:1 complex in ethanol-water (1:1, v/v) solution. The isolated pure compound 2 also exhibited high selectivity toward Cu(2+) in PBS buffer (pH = 7.0) solution. The origin of this sequence specificity of fluorescence recognition was disclosed through the crystal or optimized structures and DFT calculations of corresponding compounds.

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Section: Resultssupporting

confidence: 75%

A Selective, Sensitive, Colorimetric, and Fluorescence Probe for Relay Recognition of Fluoride and Cu(II) Ions with “Off–On–Off” Switching in Ethanol–Water Solution

et al. 2012

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“…Overdose fluoride may have toxic effects, including influencing cellular signaling pathways, inducing apoptosis and inhibiting function of ion channels 110 , 111 . Besides, fluoride might inhibit the functions of G-protein activator and Ser/Thr phosphatase and affect other important cell signaling 112 .…”

Section: Challenges In the Future Biosensor Of Fluoridementioning

confidence: 99%

Fluorescent Sensing of Fluoride in Cellular System

Jiao¹,

Zhu²,

Chen³

et al. 2015

Theranostics

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Fluoride ions have the important roles in a lot of physiological activities related with biological and medical system, such as water fluoridation, caries treatment, and bone disease treatment. Great efforts have been made to develop new methods and strategies for F- detection in the past decades. Traditional methods for the detection of F- including ion chromatography, ion-selective electrodes, and spectroscopic techniques have the limitations in the biomedicine research. The fluorescent probes for F- are very promising that overcome some drawbacks of traditional fluoride detection methods. These probes exhibit high selectivity, high sensitivity as well as quick response to the detection of fluoride anions. The review commences with a brief description of photophysical mechanisms for fluorescent probes for fluoride, including photo induced electron transfer (PET), intramolecular charge transfer (ICT), fluorescence resonance energy transfer (FRET), and excited-state intramolecular proton transfer (ESIPT). Followed by a discussion about common dyes for fluorescent fluoride probes, such as anthracene, naphalimide, pyrene, BODIPY, fluorescein, rhodamine, resorufin, coumarin, cyanine, and near-infrared (NIR) dyes. We divide the fluorescent probes for fluoride in cellular application systems into nine groups, for example, type of hydrogen bonds, type of cleavage of Si-O bonds, type of Si-O bond cleavage and cylization reactions, etc. We also review the recent reported carriers in the delivery of fluorescent fluoride probes. Seventy-four typical fluorescent fluoride probes are listed and compared in detail, including quantum yield, reaction medium, excitation and emission wavelengths, linear detection range, selectivity for F-, mechanism, and analytical applications. Finally, we discuss the future challenges of the application of fluorescent fluoride probes in cellular system and in vivo. We wish that more and more excellent fluorescent fluoride probes will be developed and applied in the biomedicine field in the future.

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“…Pycnogenol has been used by some patients to treat symptoms associated with other diseases such as melasma, erectile dysfunction, attention deficit hyperactivity disorder, arthritis and diabetes. In terms of its anti-allergic effect, pycnogenol inhibits compound 48/80 or calcium ionophore A23187 activated degranulation of rat peritoneal mast cells (RPMC) [19] possibly via its ability to scavenge free radicals [20]. In a randomized, double-blinded, placebo-controlled, crossover study in patients with varying asthma severity some beneficial effects of pycnogenol on asthma treatment were observed [21].…”

Section: Mast Cell Stabilizersmentioning

confidence: 99%

The Potential of Natural Products as Effective Treatments for Allergic Inflammation: Implications for Allergic Rhinitis

Kulka¹

2009

CTMC

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Abstract:The impact of natural products on human health has been enormous, and the study of natural products continues to influence research in the fields of chemistry, biology, and ecology. Historically, the majority of our medicines originate from natural products and their synthetic derivatives, many of which have taught us valuable lessons about biology. While advances in synthetic and combinatorial chemistry have given rise to notable successes in the development of new drugs, the perceived value of natural products in the treatment of allergic disease has yet to be fully explored. The immune system is a highly complex, intricately regulated group of cells whose integrated function is essential to health. Cells of the immune system may interact in a cell-cell manner and may also respond to intercellular messages including hormones, cytokines, and effector molecules produced by various cells. These effector molecules include histamine, kinins, leukotrienes, prostaglandins, and serotonin. The immune system can be modified by diet, pharmacologic agents, environmental pollutants, and naturally occurring food chemicals, such as vitamins and flavonoids. Allergic inflammation is mediated by several types of immune cells all of which can be effected by these naturally occurring bioactive compounds but this review will focus on mast cells and their mediators since these cells are the focal point of allergic reactions such as allergic rhinitis. The molecular mechanisms and scientific validity of some herbal remedies currently used clinically in the treatment of allergic rhinitis will be explored.

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The effect of Pycnogenol on fluoride induced rat kidney lysosomal damage in vitro

Cited by 30 publications

References 26 publications

A Selective, Sensitive, Colorimetric, and Fluorescence Probe for Relay Recognition of Fluoride and Cu(II) Ions with “Off–On–Off” Switching in Ethanol–Water Solution

A Selective, Sensitive, Colorimetric, and Fluorescence Probe for Relay Recognition of Fluoride and Cu(II) Ions with “Off–On–Off” Switching in Ethanol–Water Solution

Fluorescent Sensing of Fluoride in Cellular System

The Potential of Natural Products as Effective Treatments for Allergic Inflammation: Implications for Allergic Rhinitis

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