The effect of red grape juice on Alzheimer′s disease in rats

Siahmard, Zahra; Alaei, Hojjatollah; Reisi, Parham; Pilehvarian, Ali Asghar

doi:10.4103/2277-9175.100188

Cited by 14 publications

(3 citation statements)

References 16 publications

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“…In a different study conducted by Siahmard et al (2012), male rats were given injections of streptozocin in both lateral ventricles of the brain to cause AD by causing a biochemical and oxidative imbalance, and then were given diluted grape extract to examine the association between Vitis vinifera juice consumption and AD. The passive avoidance test data showed that AD rat models had their memory and learning abilities reduced, while AD rat models that drank red grape juice had their memory and learning abilities improved.…”

Section: Boletín Latinoamericano Y Del Caribe De Plantas Medicinales ...mentioning

confidence: 99%

“…The passive avoidance test data showed that AD rat models had their memory and learning abilities reduced, while AD rat models that drank red grape juice had their memory and learning abilities improved. Consequently, it is advised to employ Vitis vinifera in the future to prevent the progression of AD (Siahmard et al, 2012).…”

Section: Boletín Latinoamericano Y Del Caribe De Plantas Medicinales ...mentioning

confidence: 99%

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Pharmacotherapeutic potential of Vitis vinifera (grape) in age-related neurological diseases

Jadidian

2024

BLACPMA

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Age-related neurological disorders (ANDs), including neurodegenerative diseases, are complex illnesses with an increasing risk with advancing years. The central nervous system's neuropathological conditions, including oxidative stress, neuroinflammation, and protein misfolding, are what define ANDs. Due to the rise in age-dependent prevalence, efforts have been made to combat ANDs. Vitis vinifera has a long history of usage to treat a variety of illness symptoms. Because multiple ligand sites may be targeted, Vitis vinifera components can be employed to treat ANDs. This is demonstrated by the link between the structure and action of these compounds. This review demonstrates that Vitis vinifera and its constituents, including flavonoids, phenolic compounds, stilbenoids and aromatic acids, are effective at reducing the neurological symptoms and pathological conditions of ANDs. This is done by acting as an antioxidant and anti-inflammatory. The active Vitis vinifera ingredients have therapeutic effects on ANDs, as this review explains.

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Section: Boletín Latinoamericano Y Del Caribe De Plantas Medicinales ...mentioning

confidence: 99%

Section: Boletín Latinoamericano Y Del Caribe De Plantas Medicinales ...mentioning

confidence: 99%

Pharmacotherapeutic potential of Vitis vinifera (grape) in age-related neurological diseases

Jadidian

2024

BLACPMA

View full text Add to dashboard Cite

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“…Evidence has been provided that extracts from grape skin and grape seed can inhibit Aβ aggregation, presenting an AD treatment potential [ 271 ]. In an AD rat model, red grape juice intake has been found to increase learning speed and improve memory [ 272 ]. Grape seed proanthocyanidins presented the capacity to ameliorate neuronal oxidative damage and cognitive impairment in an experimental AD model [ 273 ].…”

Section: Neuroprotective Natural Products For Admentioning

confidence: 99%

Neuroprotective Natural Products for Alzheimer’s Disease

Chen

Drew

Berney

et al. 2021

Cells

137

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Alzheimer’s disease (AD) is the number one neurovegetative disease, but its treatment options are relatively few and ineffective. In efforts to discover new strategies for AD therapy, natural products have aroused interest in the research community and in the pharmaceutical industry for their neuroprotective activity, targeting different pathological mechanisms associated with AD. A wide variety of natural products from different origins have been evaluated preclinically and clinically for their neuroprotective mechanisms in preventing and attenuating the multifactorial pathologies of AD. This review mainly focuses on the possible neuroprotective mechanisms from natural products that may be beneficial in AD treatment and the natural product mixtures or extracts from different sources that have demonstrated neuroprotective activity in preclinical and/or clinical studies. It is believed that natural product mixtures or extracts containing multiple bioactive compounds that can work additively or synergistically to exhibit multiple neuroprotective mechanisms might be an effective approach in AD drug discovery.

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