The Effect of Risperidone on Metabolite Measures in the Frontal Lobe, Temporal Lobe, and Thalamus in Schizophrenic Patients. A Proton Magnetic Resonance Spectroscopy (<sup>1</sup>H MRS) Study

Szulc, Agata; Galińska, Beata; Tarasów, Eugeniusz; Dzienis, W.; Kubas, B.; Konarzewska, Beata; Walecki, Jerzy; Alathiaki, A. S.; Czernikiewicz, Andrzej

doi:10.1055/s-2005-873156

Cited by 71 publications

(78 citation statements)

References 32 publications

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“…This hypothesis is consistent with evidence that (1) drugs used to enhance NMDA receptor function in schizophrenia generally show improvement primarily in negative rather than positive symptoms (Javitt 2006;Tuominen et al 2005), (2) an magnetic resonance spectroscopy study of patients with schizophrenia has shown a correlation of temporal glutamine-glutamate levels with negative symptoms (Szulc et al 2005) and (3) negative symptoms but not positive symptoms in schizophrenic patients are correlated with decreased [ 123 I]CNS-1261 binding in the hippocampus in patients on typical antipsychotics . It should, however, be noted that in all studies to date NMDA agonists have been used only as add-on treatments to conventional antipsychotic drugs and so their potential effect on positive symptoms may have been masked.…”

Section: Ketamine Blood Levels and Psychotic Symptomssupporting

confidence: 68%

Relationship between ketamine-induced psychotic symptoms and NMDA receptor occupancy—a [123I]CNS-1261 SPET study

et al. 2008

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Section: Ketamine Blood Levels and Psychotic Symptomssupporting

confidence: 68%

Relationship between ketamine-induced psychotic symptoms and NMDA receptor occupancy—a [123I]CNS-1261 SPET study

et al. 2008

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“…We observed an effect of treatment irrespective of antipsychotic for NAA, Glx and Creatine, but this appears to be caused by higher doses pretreatment with other antipsychotics, as results disappeared after correction for baseline haloperidol equivalents. Other studies have also failed to show an effect of treatment on prefrontal NAA levels with both strong and weak D2 antagonists in recently medicated patients [37][38][39]. It has been reported that NAA did initially not decrease after treatment [34], but eventually did after multiple years [33], although the authors could not confirm whether these effects were specific to antipsychotic exposure.…”

Section: Researchcontrasting

confidence: 47%

The Effect of Aripiprazole versus Risperidone on Prefrontal Brain Metabolite Levels and Brain Volume in Psychotic Disorders: An Exploratory Study

Liemburg¹,

Sibeijn-Kuiper²,

Knegtering³

et al. 2018

Neuropsychiatry

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ObjectiveGiven that aripiprazole acts as a partial agonist on the dopamine receptor, it may have unique effects on brain neuro-metabolism, specifically in the prefrontal cortex. In this exploratory study, we investigated the effect of aripiprazole compared to risperidone on prefrontal metabolite levels (Glx, NAA, Creatine, Choline and myo-Inositol) and changes in gray and white matter volume (GMV and WMV) in patients with a psychotic disorder. We hypothesized that patients treated with aripiprazole would show increased levels of Glx and NAA and preserved brain volumes, in contrast to risperidone. MethodsIn this randomized, single blind study, patients (n=24) treated with either risperidone or aripiprazole underwent magnetic resonance spectroscopy ( 1 H-MRS) and high-resolution anatomical scans (3T) at baseline and after 9 weeks. LC Model was used to determine the absolute spectral metabolite levels and SPM12 was to perform voxel based morphometry analyses. Both metabolite levels and brain volumes were compared between treatment groups. ResultsWe found a trend for a different effect of both antipsychotics on Glx levels, whereby risperidone reduced Glx levels compared to aripiprazole. Moreover, patients treated with aripiprazole showed a decreased GMV in the precentral gyrus, caudate and lateral frontal regions and increased WMV in the precentral gyrus and a non-significant but consistent pattern of prefrontal WM increases, in contrast to risperidone. ConclusionOur results point to possibility of different effects of aripiprazole on brain volume and metabolism compared to risperidone. Studies in larger samples are needed to shed more light on the robustness and nature of such differences.

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“…One magnetic resonance spectroscopy ( 1 H-MRS) study compared a group of untreated, manic PBD patients with a group of stable BD patients treated with risperidone [35]. The ACC glutamate/glutamine (Glx) to creatine ratio (Glx/ Cr) was lower in untreated children relative to those on risperidone.…”

Section: Treatment Studies Using Functional Magnetic Spectroscopymentioning

confidence: 99%

Effects of Early Intervention on the Course of Bipolar Disorder: Theories and Realities

Pavuluri

2010

Curr Psychiatry Rep

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Given the severity and early onset of pediatric bipolar disorder, early intervention is important to bring about recovery and alter the course of the illness. There is a new and burgeoning body of literature on the biological basis of early signs of the illness and the mechanistic understanding of treatment interventions. Biological findings based on multimodal imaging, genomic studies of cellular proteins, and performance-based findings of neurocognitive studies are beginning to assemble a cohesive and interlinked model of systems neuroscience. This offers the promise of identifying biomarkers, predictors of illness, and treatment outcomes. In complement, at the tier of clinical application is a multitude of efficacy trials, yet neither a single medication nor a combination of choices seems to suffice in reality. The current review develops a point of view bridging scientific developments to where comprehensive, multipronged treatment strategies find their clinical application-a model that is similarly applicable in adult bipolar disorder.

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The Effect of Risperidone on Metabolite Measures in the Frontal Lobe, Temporal Lobe, and Thalamus in Schizophrenic Patients. A Proton Magnetic Resonance Spectroscopy (¹H MRS) Study

Abstract: Our results seem to confirm the influence of risperidone on the brain metabolism, specifically in the region of thalamus.

Cited by 71 publications

References 32 publications

Relationship between ketamine-induced psychotic symptoms and NMDA receptor occupancy—a [123I]CNS-1261 SPET study

Relationship between ketamine-induced psychotic symptoms and NMDA receptor occupancy—a [123I]CNS-1261 SPET study

The Effect of Aripiprazole versus Risperidone on Prefrontal Brain Metabolite Levels and Brain Volume in Psychotic Disorders: An Exploratory Study

Effects of Early Intervention on the Course of Bipolar Disorder: Theories and Realities

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The Effect of Risperidone on Metabolite Measures in the Frontal Lobe, Temporal Lobe, and Thalamus in Schizophrenic Patients. A Proton Magnetic Resonance Spectroscopy (1H MRS) Study

Abstract: Our results seem to confirm the influence of risperidone on the brain metabolism, specifically in the region of thalamus.

Cited by 71 publications

References 32 publications

Relationship between ketamine-induced psychotic symptoms and NMDA receptor occupancy—a [123I]CNS-1261 SPET study

Relationship between ketamine-induced psychotic symptoms and NMDA receptor occupancy—a [123I]CNS-1261 SPET study

The Effect of Aripiprazole versus Risperidone on Prefrontal Brain Metabolite Levels and Brain Volume in Psychotic Disorders: An Exploratory Study

Effects of Early Intervention on the Course of Bipolar Disorder: Theories and Realities

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The Effect of Risperidone on Metabolite Measures in the Frontal Lobe, Temporal Lobe, and Thalamus in Schizophrenic Patients. A Proton Magnetic Resonance Spectroscopy (¹H MRS) Study