The Effect of SCD Response Compression System on Coagulation and Fibrinolysis using Thromboelastography in Patients Undergoing Gastrectomy; a Comparison with Elastic Stocking

Haematological Effects of Intermittent Pneumatic Compression for Deep Vein Thrombosis Prophylaxis

“…19,24,25 Viscoelastic Assessment Thromboelastography and sonoclot 66 have both been used to determine changes in the viscosity of blood caused by IPC. 13,44,46,48 In most cases, 44,46,48 the observed changes were consistent with increased fibrinolytic activity, but there was no difference between foot and leg compression, 44 and no difference between IPC and graduated compression stockings (GCS). 48…”

“…The trials are of two types: defined short-term use of IPC (10 minutes to 2 hours) in healthy volunteers 10,16,17,31,33,34,36,37,[44][45][46][47] and patients, 10,12,14,15,18,19,21,23,34,36 and longer-term and often variable or less well defined use during and postsurgery. [6][7][8][9]11,13,20,22,[24][25][26][27][28][29][30]32,35,[38][39][40][41][42][43][48][49][50][51][52] All the trials took blood samples pre-and post-intervention, but only a minority had a true control group,…”

“…Prothrombin time, international normalised ratio, partial thromboplastin time (PTT) and activated PTT have been measured in a few of the trials, but with conflicting results. 9,13,29,30,48,51 In these few trials, where a control group was included, 29,30,51 no difference was demonstrated with those controls.…”

“…Thrombin-anti-thrombin complex (TAT) has been shown to increase in three trials 39,49,50 (although not in another 52 ), which would be consistent with increased thrombin generation. There have also been examples of reductions in anti-thrombin III 39,48 (AT III), but another did not show a change. 13 None of the trials that indicated increases in thrombin generation 39,[48][49][50] had control groups (and found similar changes with GCS 48 and fondaparinux 50 ), and in two of the trials 39,50 the change was noted within short time of surgery, and subsequently returned closer to resting levels.…”

“…Plasma fibrinogen levels have generally remained unchanged 9,17 or increased. 39,48,51 One of those trials was on healthy volunteers, 17 and no change was observed, the others were on surgical patients. 9,39,48,51 Platelet Activation and Inhibitors Very few of the trials included in this review have directly assessed the effects of IPC on platelet aggregation or its inhibition.…”