The Effect of Selenium Nanoparticles versus Royal Jelly against Cisplatin-Induced Testicular Toxicity in Adult Male Albino Rats

Mohammed, SallyS; Eisa, ChristinaS; El-Aziz, HoidaI Abd; Farghaly, LamiaM; Hosny, Somaya

doi:10.4103/jmau.jmau_44_21

Cited by 3 publications

(1 citation statement)

References 36 publications

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“…In recent years, there has been an increased focus on combination therapies combining cisplatin with antioxidants to combat various side effects, including testicular dysfunction linked to infertility. Interestingly, SeNP administration improved the histological features and weight of testes in the presence of cisplatin-induced testicular toxicity [ 90 ]; once again indicating the potential for SeNPs to preserve viable sperm.…”

Section: Selenium Nanoparticlesmentioning

confidence: 99%

Physiological Benefits of Novel Selenium Delivery via Nanoparticles

Mojadadi

Shao

et al. 2023

IJMS

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Dietary selenium (Se) intake within the physiological range is critical to maintain various biological functions, including antioxidant defence, redox homeostasis, growth, reproduction, immunity, and thyroid hormone production. Chemical forms of dietary Se are diverse, including organic Se (selenomethionine, selenocysteine, and selenium-methyl-selenocysteine) and inorganic Se (selenate and selenite). Previous studies have largely investigated and compared the health impacts of dietary Se on agricultural stock and humans, where dietary Se has shown various benefits, including enhanced growth performance, immune functions, and nutritional quality of meats, with reduced oxidative stress and inflammation, and finally enhanced thyroid health and fertility in humans. The emergence of nanoparticles presents a novel and innovative technology. Notably, Se in the form of nanoparticles (SeNPs) has lower toxicity, higher bioavailability, lower excretion in animals, and is linked to more powerful and superior biological activities (at a comparable Se dose) than traditional chemical forms of dietary Se. As a result, the development of tailored SeNPs for their use in intensive agriculture and as candidate for therapeutic drugs for human pathologies is now being actively explored. This review highlights the biological impacts of SeNPs on growth and reproductive performances, their role in modulating heat and oxidative stress and inflammation and the varying modes of synthesis of SeNPs.

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Section: Selenium Nanoparticlesmentioning

confidence: 99%

Physiological Benefits of Novel Selenium Delivery via Nanoparticles

Mojadadi

Shao

et al. 2023

IJMS

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Trace elements and metal nanoparticles: mechanistic approaches to mitigating chemotherapy-induced toxicity—a review of literature evidence

Famurewa,

George,

Ukwubile

et al. 2024

Biometals

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The Potential Preventive Role of Dapagliflozin and Metformin Alone or in Combination on the Cisplatin-Induced Renal Damage in Adult Male Albino Rats

Hassan,

Hamama,

Mahdy

et al. 2024

J Microsc Ultrastruct

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Background: Chronic kidney disease is currently a worldwide health problem with rising incidence and poor outcomes. Cisplatin (CP) is an important platinum-based anticancer drug. However, nephrotoxicity is the main limiting adverse effect. Aim: The objective of this work was to compare the probable protective effect of dapagliflozin and metformin alone or in combination on CP-induced renal damage in adult male albino rats using a histological study. Material and Methods: A total of 60 adult male albino rats were used in this study. Rats were divided into five main groups: group I (control group), which included 15 rats that were divided into four subgroups: Subgroup Ia (negative control group), which included 5 rats that received no treatment for the same periods as the experimental animals. Subgroup Ib, which included 5 rats that received intraperitonial saline once a week for 4 weeks. Subgroup Ic (dapagliflozin group), which included 5 rats that received dapagliflozin (1 mg/kg/day) by nasogastric tube for 4 weeks. Subgroup Id (metformin group), which included 5 rats that received metformin (250 mg/kg/day) by nasogastric tube for 4 weeks. The experimental group included 40 rats and was divided into the following groups: Group II (CP group), which included 10 rats that received CP (9 mg/kg) intraperitoneally once a week for 4 weeks. Group III (CP + dapagliflozin treated group), which included 10 rats that received CP (9 mg/kg) intraperitoneally once a week + dapagliflozin (1 mg/kg/day) by gavage for 4 weeks. Group IV (CP + metformin-treated group), which included 10 rats that received CP (9 mg/kg) intraperitoneally once a week + metformin (250 mg/kg/day) by gavage for 4 weeks. Group V (CP + dapagliflozin + metformin-treated group), which included 10 rats that received CP, dapagliflozin, and metformin as the previous doses for 4 weeks. Kidney specimens were subjected to histological (light and electron microscopic examination). The data were analyzed statistically. Results: The current study of group II showed disturbed normal histological architecture of renal cortex structure but groups III and IV resulted in mild preservation of the normal histological architecture of the renal cortex. Group V showed complete preservation of normal histological architecture of the renal cortex. Conclusion: CP induced structural changes on the renal cortex of adult male albino rats. Most of these changes were prevented by the usage of dapagliflozin or metformin. While the combination of both drugs protected the renal cortex.

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The Effect of Selenium Nanoparticles versus Royal Jelly against Cisplatin-Induced Testicular Toxicity in Adult Male Albino Rats

Cited by 3 publications

References 36 publications

Physiological Benefits of Novel Selenium Delivery via Nanoparticles

Physiological Benefits of Novel Selenium Delivery via Nanoparticles

Trace elements and metal nanoparticles: mechanistic approaches to mitigating chemotherapy-induced toxicity—a review of literature evidence

The Potential Preventive Role of Dapagliflozin and Metformin Alone or in Combination on the Cisplatin-Induced Renal Damage in Adult Male Albino Rats

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