The effect of selenium supplementation on coronary heart disease: A systematic review and meta-analysis of randomized controlled trials

Wen, Jianping; Li, X.; Li, Z.; Wu, Guanrui; Fu, Xiuwei; Yang, Xiaomei; Zhang, X.Q.; Gao, Xibao

doi:10.1016/j.jtemb.2017.04.009

Cited by 97 publications

(50 citation statements)

References 47 publications

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“…Selenium (Se) is an essential trace element [ 1 , 2 ] that evinces antioxidant activity [ 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 ], anti-inflammatory [ 2 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 ], antimutagenic [ 26 , 27 ], anticarcinogenic [ 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 ] or chemopreventive [ 2 , 38 , 39 , 40 , 41 , 42 , 43 , 44 ], antiviral [ 2 ], antibacterial [ 45 , 46 , 47 , 48 ], antifungal [ 49 , 50 ] and antiparasitic effects [ 51 ,…”

Section: Biochemistry Of Seleniummentioning

confidence: 99%

A Summary of New Findings on the Biological Effects of Selenium in Selected Animal Species—A Critical Review

Hosnedlová

Kępińska

Skaličková

et al. 2017

IJMS

186

121

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Selenium is an essential trace element important for many physiological processes, especially for the functions of immune and reproductive systems, metabolism of thyroid hormones, as well as antioxidant defense. Selenium deficiency is usually manifested by an increased incidence of retention of placenta, metritis, mastitis, aborts, lowering fertility and increased susceptibility to infections. In calves, lambs and kids, the selenium deficiency demonstrates by WMD (white muscle disease), in foals and donkey foals, it is associated with incidence of WMD and yellow fat disease, and in pigs it causes VESD (vitamin E/selenium deficiency) syndrome. The prevention of these health disorders can be achieved by an adequate selenium supplementation to the diet. The review summarizes the survey of knowledge on selenium, its biological significance in the organism, the impact of its deficiency in mammalian livestock (comparison of ruminants vs. non-ruminants, herbivore vs. omnivore) and possibilities of its peroral administration. The databases employed were as follows: Web of Science, PubMed, MEDLINE and Google Scholar.

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Section: Biochemistry Of Seleniummentioning

confidence: 99%

A Summary of New Findings on the Biological Effects of Selenium in Selected Animal Species—A Critical Review

Hosnedlová

Kępińska

Skaličková

et al. 2017

IJMS

186

121

View full text Add to dashboard Cite

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“…Therefore, selenium, through glutathione peroxidase, helps to protect the endothelial cells of blood vessels from the deposition of oxidized low-density lipoproteins arising from the oxidation of phospholipids and cholesterol esters. Therefore, it prevents atherosclerosis and its consequences [24][25][26].…”

Section: The Role Of Selenium In Human Organismsmentioning

confidence: 99%

Selenium-Doped Hydroxyapatite Nanocrystals–Synthesis, Physicochemical Properties and Biological Significance

et al. 2018

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Hydroxyapatites (HAs), as materials with a similar structure to bone minerals, play a key role in biomaterials engineering. They have been applied as bone substitute materials and as coatings for metallic implants, which facilitates their osseointegration. One of the beneficial characteristics of HA, when used to create biocompatible materials with improved physicochemical or biological properties, is its capacity for ionic substitution. The aim of the study was to present the current state of knowledge about HAs containing selenate ions IV or VI. The enrichment of HAs with selenium aims to create a material with advantageous effects on bone tissue metabolism, as well as having anticancer and antibacterial activity. The work is devoted to both methods of obtaining Se-HA and an evaluation of its chemical structure and physicochemical properties. In addition, the biological activity of such materials in vitro and in vivo is discussed.Pure, stoichiometric HA crystallizes in a monoclinic system, space group P2 1 /b [5]. However, it is worth mentioning that HA like this is rare and very difficult to obtain by synthesis.

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“…Moreover, some researchers have demonstrated that probiotic consumption in patients with osteoarthritis [ 11 ], type 2 diabetes mellitus (T2DM) [ 12 ], and gestational diabetes mellitus (GDM) [ 13 ] was associated with decreased inflammatory markers. On the other hand, selenium supplementation has been reported to improve antioxidant parameters in patients with metabolic syndrome [ 14 ]. In addition, in a study by Abedelahi et al [ 15 ], it was seen that sodium selenite improved the in vitro follicular development by increasing total antioxidant capacity (TAC) levels.…”

Section: Introductionmentioning

confidence: 99%

The effects of probiotic and selenium co-supplementation on parameters of mental health, hormonal profiles, and biomarkers of inflammation and oxidative stress in women with polycystic ovary syndrome

et al. 2018

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BackgroundThe aim of this study was to evaluate the effect of the co-administration of probiotic and selenium on parameters of mental health, hormonal profiles, and biomarkers of inflammation and oxidative stress in women with PCOS. Data on the effects of selenium and probiotic co-supplementation on mental health, hormonal and inflammatory parameters of patients with polycystic ovary syndrome (PCOS) are scarce. This investigation was carried out to evaluate the effects of selenium and probiotic co-supplementation on mental health, hormonal and inflammatory parameters in women with PCOS.MethodsThis randomized, double-blinded, placebo-controlled clinical trial was conducted on 60 subjects, aged 18–40 years old. Participants were randomly allocated into two groups to intake 8 × 109 CFU/day probiotic plus 200 μg/day selenium supplements (n = 30) or placebo (n = 30) for 12 weeks. Hormonal and inflammatory parameters were measured at baseline and after the 12-week intervention.ResultsProbiotic and selenium co-supplementation resulted in a significant improvement in beck depression inventory (β − 0.76; 95% CI, − 1.26, − 0.26; P = 0.003), general health questionnaire scores (β − 1.15; 95% CI, − 1.97, − 0.32; P = 0.007) and depression anxiety and stress scale scores (β − 1.49; 95% CI, − 2.59, − 0.39; P = 0.009) compared with the placebo. Furthermore, probiotic and selenium co-supplementation significantly reduced total testosterone (β − 0.26 ng/mL; 95% CI, − 0.51, − 0.02; P = 0.03), hirsutism (β − 0.43; 95% CI, − 0.74, − 0.11; P = 0.008), high-sensitivity C-reactive protein (hs-CRP) (β − 0.58 mg/L; 95% CI, − 0.97, − 0.19; P = 0.004) and malondialdehyde (MDA) levels (β − 0.29 μmol/L; 95% CI, − 0.56, − 0.02; P = 0.03), and significantly increased total antioxidant capacity (TAC) (β + 84.76 mmol/L; 95% CI, + 48.08, + 121.44; P < 0.001) and total glutathione (GSH) levels (β + 26.78 μmol/L; 95% CI, + 4.33, + 49.23; P = 0.02) compared with the placebo.ConclusionsOverall, the co-administration of probiotic and selenium for 12 weeks to women with PCOS had beneficial effects on mental health parameters, serum total testosterone, hirsutism, hs-CRP, TAC, GSH and MDA levels.This study was prospectively registered in the Iranian website (www.irct.ir) for registration of clinical trials (http://www.irct.ir: IRCT20170513033941N22).Trial registrationIRCT20170513033941N22.

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The effect of selenium supplementation on coronary heart disease: A systematic review and meta-analysis of randomized controlled trials

Cited by 97 publications

References 47 publications

A Summary of New Findings on the Biological Effects of Selenium in Selected Animal Species—A Critical Review

A Summary of New Findings on the Biological Effects of Selenium in Selected Animal Species—A Critical Review

Selenium-Doped Hydroxyapatite Nanocrystals–Synthesis, Physicochemical Properties and Biological Significance

The effects of probiotic and selenium co-supplementation on parameters of mental health, hormonal profiles, and biomarkers of inflammation and oxidative stress in women with polycystic ovary syndrome

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