The Effect of Several Compounds on the Inhibition of Bacterial Growth by Sulfaguanidine, Sulfamerazine, and Sulfasuxidine

Abstract

Sulfaguanidine, sulfamerazine, and sulfasuxidine have been found to be particularly effective in preventing the growth of the gram-negative intestinal bacilli. Each compound has a different N' substituted group. Berkman and Koser (1943) have shown that sulfapyridine interferes with nicotinamidestimulated respiration of a dysentery bacillus. It has been shown that sulfathiazole inhibits the carboxylase activity of Staphylococcus aureus (Sevag et al.,