The Effect of Shift Work on Cortisol Production in Female Hospital Employees: Study in Progress

Abstract

Introduction Cardiovascular disease (CVD) is currently the leading cause of death worldwide, contributing to 30% of all deaths. CVD etiology is complex, with many modifiable and nonmodifiable risk factors. Epidemiological evidence generally supports an association between shiftwork and an increased risk for CVD. However, the underlying physiological mechanisms remain poorly understood. Limited research suggests that the production of cortisol may differ between shift workers and non-shift workers, resulting in physiological changes that potentially increase the risk of CVD among shift workers. This study will focus on females who comprise the largest proportion of workers in healthcare settings. Objectives 1) To describe and compare total cortisol levels and its diurnal pattern in relation to current shiftwork status, and cumulative duration of exposure to shiftwork. 2) To determine if current shiftwork status and/or cumulative duration are associated with total cortisol levels, and diurnal pattern.