The Effect of Simultaneous Internal Tamponade on Fluid Compartmentalization and Its Relationship to Cell Proliferation

Molfetta, V. De; Bottoni, Ferdinando; Arpa, Paolo; Vinciguerra, Paolo; Zenoni, S.

doi:10.1097/00006982-199212031-00009

Cited by 26 publications

(23 citation statements)

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“…This tamponade showed poor ocular tolerance because of its tendency to emulsify and to lead to severe intraocular inflammation and epiretinal membrane formation. 10,11,16 Perfluorocarbon liquids, introduced by Chang as stronghold intraoperative tool, were considered to be used as long-term postoperative tamponades. 18,33,34 However, several experimental and clinical studies demonstrated their ocular toxicity, showing that they caused significant damage to the retina, possibly on account of the high specific gravity of these substances, which exerted mechanical pressure on the retina.…”

Section: Discussionmentioning

confidence: 99%

“…The reproliferation occurred especially along a tamponade-free horizontal line involving the Heavy silicone oil D Tognetto et al posterior pole and corresponding to the interface between the two bubbles. 16,43 The combination of FALK and silicone oil could result in a single-bubble optically clear mixture, according to the proportions of the two components. This would provide a real 'heavy silicone oil'.…”

Section: Eyementioning

confidence: 99%

“…Fluorinated silicone oil was introduced as an internal tamponade in the 1990s but its use was abandoned because of a high frequency of complications. [10][11][12][13][14][15][16][17] Perfluorocarbon liquids (PFCLs) have been introduced as tools in vitreoretinal surgery and then followed their indication as heavy tamponades. [18][19][20] Nevertheless, it has been demonstrated that PFCL might not be well-tolerated as long-term internal tamponades due to retinal toxicity.…”

Section: Introductionmentioning

confidence: 99%

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A new heavy internal tamponade in vitreoretinal surgery: an in vitro study

Tognetto

Lepori

Lapasin

et al. 2008

Eye

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Aim To study the solubility of perfluorohexyloctane (F6H8) in silicone oil (polydimethylsiloxane (PDMS) 1000) and to measure the viscosity and the specific gravity of the mixture obtained (heavy silicone oil or HSO tamponade) to define the ideal ratio of these components. Methods The solubility diagram of the mixture was obtained with the turbidimetric method, indicating the miscibility of F6H8 and silicone oil 1000 at all the useful temperatures. The viscosity was measured in steady shear conditions by using a controlled stress rheometer (Haake RS150) and a double cone/plate (DC 60/4) system, both at 25 and 371C for different volume per cent compositions of the mixture. The specific gravity was measured at 371C using a digital densimeter. Results A mixture of F6H8 30 v% and PDMS 70 v% was found to be transparent and stable at all the useful temperatures. By combining these proportions of the two substances, a resultant density of 1.06 g/cm 3 was obtained. The viscosity of the 30% F6H8 mixture was 203 mPa.s at 251C and 163 mPa.s at 371C respectively. Conclusions The ideal F6H8 and silicone oil mixture can be obtained combining 30% of F6H8 with 70% of silicone oil 1000. This mixture seems to have rheological properties useful for its use as an alternative intraocular heavy tamponade.

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Section: Discussionmentioning

confidence: 99%

Section: Eyementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A new heavy internal tamponade in vitreoretinal surgery: an in vitro study

Tognetto

Lepori

Lapasin

et al. 2008

Eye

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“…32 Double filling has been tried with fluorinated silicone and conventional silicone. 47 When redetachment occurred, it occupied a 'new space horizontally between the bubbles and expanding in a triangular shape nasally to the optic disk and temporally to the macula'. 48 …”

Section: Double Filling With F6h8 and Silicone Oilmentioning

confidence: 99%

Heavy tamponade 1: a review of indications, use, and complications

Heimann

Stappler

Wong

2008

Eye

117

125

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Background Heavier than water intraocular tamponades have several theoretical advantages over conventional tamponades, especially in the treatment of complicated retinal detachments and proliferative viteroretinopathy of the lower fundus periphery. However, initial clinical series of various heavy tamponades have reported significant complication rates. Therefore, heavy tamponades have not found widespread acceptance. Three recently developed heavy silicone oil tamponades, Oxane HD, Densiron 68, and HWS 46-3000, are much better tolerated and presently seem to enter routine clinical practice. Materials and methods Literature review of 21 publications on the clinical application of 9 different heavy tamponades (fluorosilicone, C10F18, F6H8, OL62HV, Oxane HD, O62, F6H8-silicone oil mixture, Densiron 68, and HWS 46-3000). Results The first generation (fluorinated silicone and perfluorocarbon liquids) and second generation (partially fluorinated alkanes) of heavy tamponades were associated with relatively high complication rates, for example, tamponade emulsification, intraocular inflammation, and rise in intraocular pressure. The complication spectrum of the new generation of heavy silicone oils (Oxane HD, Densiron 68, and HWS 46-3000) seems to be comparable to conventional silicone oil tamponades while providing better support for the inferior retina and the posterior pole. Conclusion The recently developed heavy silicone oil tamponades are safe and effective tools for the use of complicated retinal detachments of the inferior fundus.

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“…The combined use of silicone oil 1,000 mPas and perfluorocarbon liquids (PFCLs) has been suggested as a long-term endotamponade in the treatment of complex retinal detachment [1,2,3]. PFCLs with a high density of 1.7–2.1 g/cm 3 provide a good endotamponading force to the inferior retina.…”

Section: Introductionmentioning

confidence: 99%

Long-Term Vitreous Replacement with Perfluorohexyloctane and Silicone Oil: Preliminary Reports of a Multicentric Study

Rizzo

Genovesi-Ebert²,

Belting³

et al. 2005

Ophthalmologica

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Aim: To report on the use of a combined intra-ocular tamponade with silicone oil and perfluorohexyloctane (F₆H₈) in the treatment of complex retinal detachment. Design: A prospective consecutive interventional case series from seven study centres. Participants: 69 patients presenting a retinal detachment with proliferative vitreoretinopathy (PVR) and retinal breaks of the inferior two quadrants of the fundus. Method: Patients were divided into two groups: (1) 28 eyes which had not been operated on before; (2) 41 eyes affected by recurrent retinal detachment that had had unsuccessful previous surgery with silicone oil or gas tamponade. A pars plana vitrectomy, membrane peeling and – when necessary – a retinotomy were performed; the vitreous cavity was filled with two thirds of F₆H₈ and one third of silicone oil 1,000 mPas (double filling, DF). The endotamponade was removed after 30–45 days (median 38) and replaced by balanced salt solution or silicone oil according to the condition of the retina. Results: Retinal reattachment was achieved in 52 out of 69 cases (75%) 6 months after removal of the DF without any endotamponade. Conclusion: The DF with F₆H₈ and silicone oil allows a good endotamponading to the inferior retina and the posterior pole. The DF appeared to be well tolerated. Further studies are necessary to evaluate whether a DF is advantageous in respect to silicone oil filling alone in case of retinal breaks and PVR of the inferior retina.

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The Effect of Simultaneous Internal Tamponade on Fluid Compartmentalization and Its Relationship to Cell Proliferation

Cited by 26 publications

References 0 publications

A new heavy internal tamponade in vitreoretinal surgery: an in vitro study

A new heavy internal tamponade in vitreoretinal surgery: an in vitro study

Heavy tamponade 1: a review of indications, use, and complications

Long-Term Vitreous Replacement with Perfluorohexyloctane and Silicone Oil: Preliminary Reports of a Multicentric Study

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