The effect of skin moisture,<scp>pH</scp>, and temperature on the density of<i>Demodex folliculorum</i>and<i>Demodex brevis</i>(Acari: Demodicidae) in students and staff of the Erzincan University, Turkey

Zeytun, Erhan; Tilki, Engin; Doğan, Salíh; Mumcuoglu, Kosta Y.

doi:10.1111/ijd.13600

Cited by 30 publications

(24 citation statements)

References 23 publications

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“…This hypothesis can be supported by our observation that D. folliculorum was more prevalent on skin among patients reporting use of TCS, which is in alignment with ndings from a study of patients with perioral dermatitis [25]. A second hypothesis could be that the skin conditions in AD itself favour D. folliculorum colonization, as slightly higher colonization frequencies have been observed among people with higher skin pH and lower skin hydration [26], as present in AD.…”

Section: Discussionsupporting

confidence: 87%

Identification of Cutaneous Fungi and Mites in Adult Atopic Dermatitis: Analysis by Targeted 18S rRNA Amplicon Sequencing

Edslev

Andersen

Ingham

et al. 2020

Preprint

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Background: Atopic dermatitis (AD) patients have a changed skin bacterial community, with high abundance of Staphylococcus aureus associated with flairs, highlighting that microbial organisms may be important for disease exacerbation. Despite strong evidence of association between bacterial skin colonization and AD, very limited knowledge regarding the eukaryotic microbial community, including fungi and ectoparasites, in AD exists. In this study, we compared the skin and nasal eukaryotic microbial community between adult AD patients (n=55) and non-AD healthy controls (n=45) using targeted 18S rRNA amplicon sequencing. Analysis was based on the presence or absence of eukaryotic microorganisms. Results: The cutaneous composition of the eukaryotic microbial community and the alpha-diversity differed significantly between AD patients and non-AD individuals, with increased species richness on AD skin. Alpha-diversity and beta-diversity were similar on lesional and non-lesional skin of patients. The ectoparasite Demodex folliculorum and the yeast Geotrichum candidum were significantly more prevalent on the skin of AD patients. The prevalence of D. folliculorum on lesional skin was greater among patients recently treated with topical corticosteroid. Malassezia was one of the most frequently detected genera at all sites, with M. globosa and M. restricta being the most prevalent. M. restricta was overrepresented in the anterior nares of AD patients as compared to the non-AD control population. Conclusion: Significant differences in the eukaryotic microbial communities were found between AD patients and non-AD individuals, with the most striking finding being the significantly overrepresentation of D. folliculorum on AD skin. Whether D. folliculorum can contribute to skin inflammation in AD needs further investigation.

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Section: Discussionsupporting

confidence: 87%

Identification of Cutaneous Fungi and Mites in Adult Atopic Dermatitis: Analysis by Targeted 18S rRNA Amplicon Sequencing

Edslev

Andersen

Ingham

et al. 2020

Preprint

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“…[20][21][22][23][24][25][26][27][28][29] Demodex species positivity was found in 6.7-74.7% of the healthy Turkish population living in various regions. [20][21][22][23][24][25][26][27][28][29] There may be several reasons for the differences among regions and many other factors may influence the prevalence of Demodex mite presence. It has been stated that the number of parasites increases, particularly in the summer months, with an increase in environmental temperature; this may occur through the seasonal activation of sebum production.…”

Section: Discussionmentioning

confidence: 99%

Demodex Species Frequency and Risk Factors in Patients With Rheumatoid Arthritis

et al. 2020

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Objectives: This study aims to investigate the presence of Demodex species in rheumatoid arthritis (RA) patients, to identify the risk factors for developing Demodex infestation, and to determine the effect of immunosuppressant drugs on Demodex mite infestations. Patients and methods: The study included 93 RA patients (16 males, 77 females; mean age 53.3±11.3 years; range, 27 to 83 years) and 76 healthy controls (19 males, 57 females; mean age 50.3±13.9 years; range, 19 to 86 years). Specimens were collected from face skin by using standardized surface skin biopsy. Demodex infestation was considered for ≥5 living parasites/cm 2 of skin while Demodex mite presence was defined as any Demodex larvae, adults, or eggs found in the specimen. Results: The frequencies of Demodex mite presence were 44% for the RA patients and 15.7% for the healthy controls (p<0.001). The rates of Demodex infestation were similar between the two groups (18.3% versus 7.9%, p=0.054). There were no statistically significant differences between the groups regarding skin type, skin care, epilation, body washing, use of a moisturizer, personal towel use, the number of residents at home, or whether there were pets at home or in proximity. Itching in eyes was higher in RA patients, but the frequency of other skin symptoms was not different from healthy controls. Logistic regression analysis indicated that the diagnosis of RA was an independent risk factor for Demodex mite presence in this study population. Disease activity and duration, use of corticosteroids, conventional disease-modifying anti-rheumatic drugs (DMARDs) and biological DMARDs were not effective factors on Demodex mite presence in RA patients. Conclusion: Although Demodex mite presence was 3.5-fold higher in RA patients, the rate of Demodex infestation was similar to that of healthy controls.

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“…The pathogenesis of rosacea is multi-factorial when demodex is involved (Zhao et al 2010; Rios-Yuil et al 2013). Overproliferation of mites can plug the pilosebaceous ducts, leading to a rosacea-like facial eruption (Zeytun et al 2017). The acaricidal, antibacterial, antipruritic, anti-inflammatory and wound-healing effects of TTO (Thomas et al 2016) may be able to manage demodex-related dermatological conditions.…”

Section: Discussionmentioning

confidence: 99%

Can the tea tree oil (Australian native plant:Melaleuca alternifolia Cheel) be an alternative treatment for human demodicosis on skin?

et al. 2018

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Australian tea tree oil (TTO) and its extract terpinen-4-ol (T4O) are found to be effective in moderating demodex-related diseases. Their possible effects are lowering the mite counts, relieving the demodex-related symptoms and modulating the immune system especially the inflammatory response. This review summarizes the topical treatments of TTO and T4O in human demodicosis, their possible mechanism of actions, side-effects and potential resistance in treating this condition. Although current treatments other than TTO and T4O are relatively effective in controlling the demodex mite population and the related symptoms, more research on the efficacy and drug delivery technology is needed in order to assess its potential as an alternative treatment with minimal side-effect profile, low toxicity and low risk of demodex resistance.

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The effect of skin moisture,pH, and temperature on the density ofDemodex folliculorumandDemodex brevis(Acari: Demodicidae) in students and staff of the Erzincan University, Turkey

Abstract: Demodex mites are very prevalent in healthy individuals of both sexes, and this should be taken into consideration when epidemiological and clinical studies are conducted with patients having different dermatological ailments.

Cited by 30 publications

References 23 publications

Identification of Cutaneous Fungi and Mites in Adult Atopic Dermatitis: Analysis by Targeted 18S rRNA Amplicon Sequencing

Identification of Cutaneous Fungi and Mites in Adult Atopic Dermatitis: Analysis by Targeted 18S rRNA Amplicon Sequencing

Demodex Species Frequency and Risk Factors in Patients With Rheumatoid Arthritis

Can the tea tree oil (Australian native plant:Melaleuca alternifolia Cheel) be an alternative treatment for human demodicosis on skin?

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