The Effect of Small Doses of Oestrogen on the Ovary of the Immature Rat

Paesi, F. J. A.

doi:10.1530/acta.0.0110251

Cited by 17 publications

(6 citation statements)

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“…Their conclusion was based on a number of primate studies, which indicated that an estrogen-free/poor intrafollicular environment is associated with marked decrements in the rates of meiotic maturation and fertilization [467,490]. In addition data derived from rodent models suggested that further suggested a compromise in early embryonic development [491].…”

Section: Part Twomentioning

confidence: 99%

The role of aromatase inhibitors in ameliorating deleterious effects of ovarian stimulation on outcome of infertility treatment

Mitwally

Casper

Diamond

2005

Reprod Biol Endocrinol

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Clinical utilization of ovulation stimulation to facilitate the ability of a couple to conceive has not only provided a valuable therapeutic approach, but has also yielded extensive information on the physiology of ovarian follicular recruitment, endometrial receptivity and early embryo competency. One of the consequences of the use of fertility enhancing agents for ovarian stimulation has been the creation of a hyperestrogenic state, which may influence each of these parameters. Use of aromatase inhibitors reduces hyperestrogenism inevitably attained during ovarian stimulation. In addition, the adjunct use of aromatase inhibitors during ovarian stimulation reduces amount of gonadotropins required for optimum stimulation. The unique approach of reducing hyperestrogenism, as well as lowering amount of gonadotropins without affecting the number of mature ovarian follicles is an exciting strategy that could result in improvement in the treatment outcome by ameliorating the deleterious effects of the ovarian stimulation on follicular development, endometrial receptivity, as well as oocyte and embryo quality. PART ONE IntroductionCurrent epidemiological evidence suggests that 15% of couples will experience infertility. Background prevalence rates now appear to be reasonably stable, but there is evidence of an increase in the rate of referrals for medical help [1,2]. Farley and Belsey, 1988 [3], have reported estimates of the prevalence (percentage) of primary infertility by region and country.

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Section: Part Twomentioning

confidence: 99%

The role of aromatase inhibitors in ameliorating deleterious effects of ovarian stimulation on outcome of infertility treatment

Mitwally

Casper

Diamond

2005

Reprod Biol Endocrinol

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“…Though other animal studies concluded that oestrogen free /poor intra-follicular environment was associated with decreased rates of meiotic maturation and fertilization. In addition, further compromise in early embryonic development might occur [49,58,59]. In current study the environment was not oestrogen free and it did not drop drastically below the low physiological range.…”

Section: Discussionmentioning

confidence: 67%

Aromatase Inhibitor for Prevention of Ovarian Hyperstimulation Syndrome(OHSS)

Begum¹

2014

Androl Gynecol: Curr Res

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Objective:Our aim was to explore the efficacy of aromatase inhibitor in preventing OHSS. Materials and methods:The study was conducted in Infertility Care and Research Center, Dhaka, Bangladesh. One hundred and twenty patients, who were the potential candidates for developing OHSS, were the target population. They were divided into two groups. One received tab letrozole and other group were selected for coasting for prevention of OHSS.Results: Three patients (5%) in letrozole group developed mild to moderate OHSS and no one developed severe form of OHSS. On the other hand 8.33% developed mild to moderate and 3.33% developed severe form of OHSS in coasting group. Though number of metaphase II oocyte retrieval was similar in two groups, number of grade I egg and grade I embryo were lower in letrozole group. But there was no significant difference in pregnancy rate as transferable embryo was optimum in letrozole group. No cycle was cancelled in either group and no ET was deferred in letrozole group, whereas in 5 (8.33%) cases embryo transfer was deferred in coasting group. Conclusion:The results of this study suggest that without compromising the result of ART aromatase inhibitor can be used to reduce oestrogen level and prevent the severity of OHSS.

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“…[163][164][165][166] Regarding the effect of an estrogen-free/poor intrafollicular environment on gametogenic maturation, Palter et al 142 concluded that there may be a negative effect based on a number of primate studies that suggested that an estrogen-free/poor intrafollicular environment was associated with decreased rates of meiotic maturation and fertilization. [167][168] In addition data derived from rodent models suggested that further compromise in early embryonic development might occur. 169 However, the high success rates of ovulation and achievement of pregnancy in our reports despite low peripheral estrogen levels suggest no adverse outcome associated with the use of aromatase inhibition for ovarian stimulation.…”

Section: Effect Of Low Estrogen Milieu On the Developing Oocytesmentioning

confidence: 99%

Aromatase Inhibitors in Ovulation Induction

Mitwally

Casper²

2004

Semin Reprod Med

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The new third generation aromatase inhibitors are extremely potent and specific oral inhibitors of estrogen production. We reported the success of using aromatase inhibitors for induction of ovulation in World Health Organization (WHO) type II anovulatory patients. Promising pregnancy rates were associated with the use of aromatase inhibitors for induction of ovulation in these women. In addition, the use of aromatase inhibition in conjunction with gonadotropin injection was associated with a significant reduction in the gonadotropin dose required for optimum controlled ovarian hyperstimulation. We believe that these oral agents are efficient and safe and have many advantages compared with clomiphene citrate (CC). We propose that aromatase inhibitors will replace CC in the future as the new primary treatment for ovulation induction. In this review, we present an update on the use of aromatase inhibitors for induction of ovulation and we discuss several new areas of potential interest regarding the use of aromatase inhibitors, either alone or together with recombinant follicle-stimulating hormone (FSH) for infertility treatment. Further research in these areas may demonstrate an expanded role in assisted reproductive technologies.

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The Effect of Small Doses of Oestrogen on the Ovary of the Immature Rat

Cited by 17 publications

References 0 publications

The role of aromatase inhibitors in ameliorating deleterious effects of ovarian stimulation on outcome of infertility treatment

The role of aromatase inhibitors in ameliorating deleterious effects of ovarian stimulation on outcome of infertility treatment

Aromatase Inhibitor for Prevention of Ovarian Hyperstimulation Syndrome(OHSS)

Aromatase Inhibitors in Ovulation Induction

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