The Effect of Spaying on Body Growth and the Organ Weights of the Albino Rat

Sex and timing of gonadectomy relative to puberty interact to influence weight, body composition, and feeding behaviors in mice

“…In females, postpubertal OVX caused significant weight gain compared to sham, but prepubertal OVX did not significantly affect weight. These findings indicate that age at surgery determines the response to OVX in mice, consistent with one report that pubertal suppression of ovarian hormones does not affect weight gain in rats (Hodgson et al, 2020) but inconsistent with other reports that prepubertal OVX in rats increased weight compared to sham (Clark and Tarttelin, 1982;Freudenberger and Billeter, 1935;Freudenberger and Howard, 1937;Grant et al, 2021).…”