The effect of sterilisation on a poly(dimethylsiloxane)/poly(hexamethylene oxide) mixed macrodiol-based polyurethane elastomer

Simmons, Anne; Hyvarinen, Jari; Poole-Warren, Laura A.

doi:10.1016/j.biomaterials.2006.04.017

Cited by 90 publications

(81 citation statements)

References 41 publications

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“…In this study, a behavior typical of oxidative degradation was observed: increase in mean tension at maximum force in the initial phase of the process and a downward trend due to the cumulative effect of degradation (8,(10)(11) . The mean tension at maximum force increased until the third reprocessing and tended to decrease from that point onwards.…”

Section: Mechanical Functionality Of the Cardiac Angiographic Cathetersmentioning

confidence: 99%

“…The modifications in the catheters' mechanical properties in one single cycle can be explained by the action of the hydrogen peroxide plasma in the initial phase of the oxidative degradation process, in which the chain split and crosslinking formation reactions can occur simultaneously (8,10) . In this case, the rupture of bonds may have prevailed, as the greater mobility and orientation of the chains produced optimal stiffness for the catheters, making them more ductile and flexible.…”

Section: Mechanical Functionality Of the Cardiac Angiographic Cathetersmentioning

confidence: 99%

“…It was inferred that the negative effect on ductility and resistance after one single sterilization was due to the low thickness of the assessed material (0.50mm) (8) . The thickness of the catheters in this study (0.55mm), however, also permitted similar exposure to hydrogen peroxide plasma and its properties were modified in a positive way for the material.…”

Section: Mechanical Functionality Of the Cardiac Angiographic Cathetersmentioning

confidence: 99%

“…Among degradation types, oxidative degradation is the process most involved in devices sterilized through the hydrogen peroxide plasma method, as its decomposition produces free radicals like hydroperoxides (ROOH) and hydroxyl radicals (.OH) which, due to their high oxidation power, start the degradation process of the polymers constituting the catheters, thus altering the mechanical and structural performance of the thermo-sensitive devices submitted to the sterilization cycles (7)(8) .…”

Section: Reprocessing Protocolmentioning

confidence: 99%

“…A study assessed the mechanical properties of two different types of polyurethane elastomers used in the production of implantable biomaterials sterilized in Sterrad ® 100S one single time (8) . The comparison with materials that were not reprocessed (control), a great increase in the elasticity module was verified, accompanied by significant change in material stiffness (p=0.003/CI=95%) and an important reduction in the mean deformation at maximum force (9) .…”

Section: Mechanical Functionality Of the Cardiac Angiographic Cathetersmentioning

confidence: 99%

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Validação do reprocessamento de cateteres cardíacos angiográficos: uma avaliação da funcionalidade e da integridade

Lucas

Pinotti²,

Oliveira

2010

Rev. esc. enferm. USP

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Portuguese / English: www.scielo.br/reeusp RESUMO Objetivou-se validar o reprocessamento de cateteres cardíacos angiográficos quanto às suas características de funcionalidade mecâ-nica e à integridade molecular e micro-estrutural da cadeia polimérica. Pesquisa experimental, aplicada, comparativa e controlada. Construiu-se uma bancada de simulação de uma arteriografia de coronária esquerda para simular um estresse mecânico e biológico em cateteres. Testou-se a funcionalidade por ensaio de tração e a integridade por Espectroscopia na Região do Infravermelho e Microscopia Eletrônica de Varredura. Evidenciou-se uma tendência ao aumento da rigidez a cada acréscimo do número de reprocessamento (p<0,05). As modificações das propriedades mecânicas e das estruturas moleculares dos polímeros foram mais evidentes a partir do quinto reprocessamento. As micrografias revelaram o aumento de rugosidade a partir do quarto reprocessamento. Os resultados deste estudo poderão contribuir para a elaboração de protocolos de reprocessamento e vigilância sistemática da reutilização de materiais de uso único, não apenas por sua relevância econômica, mas sobretudo do ponto de vista ético, legal, biológico, funcional e assistencial. DESCRITORES ABSTRACTThe objective of this study was to validate the reprocessing of angiographic cardiac catheters regarding their characteristics of mechanical functionality and the molecular and micro-structural integrity of the polymeric chain. This is an experimental, applied, comparative and controlled study. A simulation set was built for a left coronary angiography in order to simulate mechanical and biological stress in the catheters. Traction tests were performed for the functionality and the integrity was tested through Infrared Spectrometry and Scanning Electronic Microscopy. The study evidenced a tendency to an increase in rigidity at every increment of the reprocessing number (p<0.05). The changes in the mechanical properties and molecular structures of the polymers were more evident as of the fifth reprocessing. Micrographies revealed an increase in rugosity as of the forth reprocessing. The results of this study may contribute to the elaboration of reprocessing protocols and a systematic surveillance of the reutilization of single use materials, not only due to their economical relevance, but especially from the ethical, legal, biological, functional and care point of view.

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Section: Mechanical Functionality Of the Cardiac Angiographic Cathetersmentioning

confidence: 99%

Section: Mechanical Functionality Of the Cardiac Angiographic Cathetersmentioning

confidence: 99%

Section: Mechanical Functionality Of the Cardiac Angiographic Cathetersmentioning

confidence: 99%

Section: Reprocessing Protocolmentioning

confidence: 99%

Section: Mechanical Functionality Of the Cardiac Angiographic Cathetersmentioning

confidence: 99%

See 3 more Smart Citations

Validação do reprocessamento de cateteres cardíacos angiográficos: uma avaliação da funcionalidade e da integridade

Lucas

Pinotti²,

Oliveira

2010

Rev. esc. enferm. USP

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The effect of different sterilization procedures on chitosan dried powder

Yang

Zhao

Liu

et al. 2007

J of Applied Polymer Sci

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The aim of this study was to investigate the effects induced by three different sterilization methods [steam, g-radiation, and ethylene oxide (EO)] with different dose or time period of sterilization by means of Fourier transform infrared spectroscopy, X-ray diffraction, and assessments of molecular weight and degree of deacetylation. The experiment results clearly showed that the steam sterilization greatly darkened the color of chitosan powder; g-irradiation strongly depolymerized the chitosan especially at irradiation dose above 10 kGy; and exposure to EO led to minor change in crystallinity and network structure of chitosan powder. Therefore, these three methods have their respective advantages and disadvantages, suggesting that the selection of the sterilization method of chitosan should depend upon the specific requirement of the final application.

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Synthesis and characterization of a novel polyurethane elastomer based on CO₂ copolymer

Zhang

2007

J of Applied Polymer Sci

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Novel poly(ethylene ether carbonate) polyurethane elastomers (PEC-PUE) based on methylene diphenyl diisocyanate (MDI) and poly(ethylene ether carbonate) diol (PEC) were prepared and characterized. The diol PEC was a new material obtained by copolymerization of ethylene oxide and CO 2 in the presence of polymer supported bimetallic catalyst (PBM). When the diol PEC reacted with MDI and with 1,4-butanediol as the chain extender, a novel polyurethane elastomer can be formed. The elastomer was characterized by FTIR and 1 H NMR. The mechanical properties were studied by tensile set and the thermal properties were studied by TGA. Results of the tests indicated that mechanical strength of the elastomer can be improved by adjusting the ratio of NCO/ OH. The thermal stability as well as tensile strength (TS) decreased sharply after being exposed to moisture and with bonded water in the polymer structure. It was also discovered that as the bonded water evaporated, both the thermal stability and TS would recover. Moreover, shape memory behaviors of the elastomer were also studied, and it was found that all the samples tested returns to its original shape in 100 s.

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The effect of sterilisation on a poly(dimethylsiloxane)/poly(hexamethylene oxide) mixed macrodiol-based polyurethane elastomer

Cited by 90 publications

References 41 publications

Validação do reprocessamento de cateteres cardíacos angiográficos: uma avaliação da funcionalidade e da integridade

Validação do reprocessamento de cateteres cardíacos angiográficos: uma avaliação da funcionalidade e da integridade

The effect of different sterilization procedures on chitosan dried powder

Synthesis and characterization of a novel polyurethane elastomer based on CO₂ copolymer

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The effect of sterilisation on a poly(dimethylsiloxane)/poly(hexamethylene oxide) mixed macrodiol-based polyurethane elastomer

Cited by 90 publications

References 41 publications

Validação do reprocessamento de cateteres cardíacos angiográficos: uma avaliação da funcionalidade e da integridade

Validação do reprocessamento de cateteres cardíacos angiográficos: uma avaliação da funcionalidade e da integridade

The effect of different sterilization procedures on chitosan dried powder

Synthesis and characterization of a novel polyurethane elastomer based on CO2 copolymer

Contact Info

Product

Resources

About

Synthesis and characterization of a novel polyurethane elastomer based on CO₂ copolymer