The effect of structural configuration on the DNA binding andin vitroantioxidant properties of new copper(ii) N₂O₂Schiff base complexes

Abstract

DNA interaction with cis and trans-copper NO complexes favours the cis configuration due to low energies observed in the cis configuration.

Synthesis and Therapeutic Potential of selected Schiff Bases: In vitro Antibacterial, Antioxidant, Antidiabetic, and Computational Studies

“…It is common knowledge that reactive oxygen species (ROS) created during biochemical processes in the body, including superoxide anion, hydroxyl radical, and hydrogen peroxide, are highly reactive and potentially harmful transient chemical substances. These ROS can cause oxidative damage to lipids, proteins, and nucleic acids, leading to various chronic diseases, such as coronary heart disease, atherosclerosis, cancer, and aging [49,50] . Therefore, it is crucial to administer drugs rich in antioxidants to prevent free radical damage in the body.…”

“…These ROS can cause oxidative damage to lipids, proteins, and nucleic acids, leading to various chronic diseases, such as coronary heart disease, atherosclerosis, cancer, and aging. [49,50] Therefore, it is crucial to administer drugs rich in antioxidants to prevent free radical damage in the body. In this study, DPPH, FRAP, and NO antioxidant assay methods were done using different concentrations of L 1 -L 3 and Trolox as a standard.…”

Synthesis, characterization, biological evaluation, DFT and molecular docking studies of (Z)-2-((2-bromo-4-chlorophenyl)imino)methyl)-4-chlorophenol and its Co(ii), Ni(ii), Cu(ii), and Zn(ii) complexes

“…These distances agree with similar structures previously reported. [56][57][58] Non-classical hydrogen bond exists in the crystal system of the lattice structure (Fig. 2).…”

Investigations on a mononuclear Cu(ii) Schiff base complex: theoretical calculations, catechol oxidase activity, and protein binding interaction analysis

“…Transition metal complexes with Schiff base ligands have received noteworthy interest from the scientific fraternity in the last few decades owing to their fascinating structural topology, magnetism, and catalytic and biological activity. [1][2][3][4][5][6][7][8] Schiff bases have gained great importance due to their wide range of applications, such as anticancer, 9,10 anti-inflammatory, 11,12 antimicrobial, 1,13,14 antioxidant, 15,16 photophysical, 17,18 optical, 19,20 catalytic 21,22 and electrochemical properties. 23,24 Among all the inorganic transition metal ions copper(II)-containing compounds with an advanced mode of design have been explored for various catalytic activities, protein-complex binding studies, proteins and the role of catechol oxidases is to catalyze the oxidation of catechols to orthoquinones in the presence of air.…”