The effect of temporary hypoxia on prostaglandin synthesis in mouse brain cell cultures during development

Neuroprotective role of bradykinin because of the attenuation of pro‐inflammatory cytokine release from activated microglia

“…BK receptors are not only present on neurons (Delmas et al 2002), but also on all types of glial cells, astrocytes, and oligodendrocytes (Gimpl et al 1992;Hosli et al 1992;Lin and Chuang 1992;Stephens et al 1993a,b) and, as recently demonstrated, also on microglial cells (Noda et al 2003(Noda et al , 2004. In astrocytes, BK stimulates the release of arachidonic acid (Burch and Kniss 1988;Kaeser et al 1988) and induces the calcium-dependent release of glutamate and IL-6 expression (Parpura et al 1994;Schwaninger et al 1999).…”

“…2003, 2004). In astrocytes, BK stimulates the release of arachidonic acid (Burch and Kniss 1988; Kaeser et al. 1988) and induces the calcium‐dependent release of glutamate and IL‐6 expression (Parpura et al.…”