The Effect of Terpenoid Natural Chinese Medicine Molecular Compound on Lung Cancer Treatment

Sun, Heng; Zhang, Lijia; Sui, Bowen; Yu, Lap-Fai; Yan, Jun; Wang, Peng; Wang, Ye; Liu, Songjiang

doi:10.1155/2021/3730963

Cited by 7 publications

(7 citation statements)

References 106 publications

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“…Many of them have pharmacological activitiesanticancer, antimicrobial, and anti-inflammatory. , Because of their diversity and interesting properties, they have become important ingredients in food, cosmetics, and pharmaceuticals. Their chemical synthesis is usually unprofitable or unsustainable, so efficient extraction from natural sources seems to be a very important direction in research and industrial development. − Table presents a few examples of terpenes and terpenoids, with their activities and possible applications. ,− …”

Section: The Most Interesting Bioactive Compounds Extracted With Dess...mentioning

confidence: 99%

The Most Potent Natural Pharmaceuticals, Cosmetics, and Food Ingredients Isolated from Plants with Deep Eutectic Solvents

Wawoczny

Gillner

2023

J. Agric. Food Chem.

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There is growing interest in reducing the number of synthetic products or additives and replacing them with natural ones. The pharmaceutical, cosmetic, and food industries are especially focused on natural and bioactive chemicals isolated from plants or microorganisms. The main challenge here is to develop efficient and ecological methods for their isolation. According to the strategies and rules of sustainable development and green chemistry, green solvents and environmentally friendly technologies must be used. The application of deep eutectic solvents as efficient and biodegradable solvents seems to be a promising alternative to traditional methods. They are classified as being green and ecological but, most importantly, very efficient extraction media compared to organic solvents. The aim of this review is to present the recent findings on green extraction, as well as the biological activities and the possible applications of natural plant ingredients, namely, phenolics, flavonoids, terpenes, saponins, and some others. This paper thoroughly reviews modern, ecological, and efficient extraction methods with the use of deep eutectic solvents (DESs). The newest findings, as well as the factors influencing the efficiency of extraction, such as water content, and hydrogen bond donor and acceptor types, as well as the extraction systems, are also discussed. New solutions to the major problem of separating DESs from the extract and for solvent recycling are also presented.

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Section: The Most Interesting Bioactive Compounds Extracted With Dess...mentioning

confidence: 99%

The Most Potent Natural Pharmaceuticals, Cosmetics, and Food Ingredients Isolated from Plants with Deep Eutectic Solvents

Wawoczny

Gillner

2023

J. Agric. Food Chem.

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“…A report made by the University of North Carolina at Chapel Hill Lineberger Comprehensive Cancer Center in the United States revealed that 76.8% of lung cancer patients had received CAM treatment after diagnosis [10]. As a representative type of CAM, traditional Chinese medicine (TCM) plays a significant role in health maintenance in China and parts of East Asia [11][12][13]. TCM is the collective name of medicine of all nationalities in China, including Chinese and minority medicine, and is a system of medicine that reflects the Chinese nation's understanding of life, health, and disease, with a long historical tradition and unique theories and technical methods.…”

Section: Introductionmentioning

confidence: 99%

Costs of traditional Chinese medicine treatment for inpatients with lung cancer in China: a national study

Nie

Han

Nicholas

et al. 2023

BMC Complement Med Ther

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Background Traditional Chinese Medicine (TCM) has long been a widely recognized medical approach and has been covered by China’s basic medical insurance schemes to treat lung cancer. But there was a lack of nationwide research to illustrate the impact of the use of TCM on lung cancer patients’ economic burden in mainland China. Therefore, we conduct a nationwide study to reveal whether the use of TCM could increase or decrease the medical expenditure of lung cancer inpatients in mainland China. Methods This is a 7-year cross-sectional study from 2010 to 2016. The data is a random sample of 5% from lung cancer claims data records of Chinese Urban Employee Basic Medical Insurance (UEBMI) and Urban Resident Basic Medical Insurance (URBMI). Mann-Whitney test was used to compare inpatient cost data with positive skewness. Ordinary least squares regression analysis was performed to compare the total TCM users’ hospitalization cost with TCM nonusers’, to examine whether TCM use is the key factor inducing relatively high medical expenditure. Result A total of 47,393 lung cancer inpatients were included in this study, with 38,697 (81.7%) of them at least using one kind of TCM approach. The per inpatient medical cost of TCM users was RMB18,798 (USD2,830), which was 65.2% significantly higher than that of TCM nonusers (P < 0.001). The medication cost, conventional medication cost, and nonpharmacy cost of TCM users were all higher than TCM nonusers, illustrating the higher medical cost of TCM users was not induced by TCM only. With confounding factors fixed, there was a positive correlation between TCM cost and conventional medication cost, nonpharmacy cost (Coef. = 0.283 and 0.211, all P < 0.001), indicting synchronous increase of TCM costs and conventional medication cost for TCM users. Conclusion The use of TCM could not offset the utilization of conventional medicine, demonstrating TCM mainly played a complementary role but not an alternative role in the inpatient treatment of lung cancer. A joint Clinical Guideline that could balance the use of TCM and Conventional medicine should be developed for the purpose of reducing economic burden for lung cancer inpatients.

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“…Several achievements have been made in the research and development of traditional Chinese medicines with anti-cancer potential [4]. However, at present, most of the studies are based on compound therapy.…”

Section: Introductionmentioning

confidence: 99%

Isoginkgetin inhibits lung cancer cell progression through miR-27a-5p/APEX1 axis

Wu¹,

Li²

2022

Trop. J. Pharm Res

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Purpose: To determine the influence of isoginkgetin on the progression of pulmonary carcinogenesis. Methods: A549 cells exposed to isoginkgetin were transfected with miR-27a-5p mimetic and suppressor, as well as short hairpin RNA against apurinic/apyrimidinic endo-deoxyribonuclease 1 (sh-APEX1) for 24 h. Then, the proliferative, migration and invasive potential of A549 cells were determined using CCK-8, wound healing and Transwell assays, respectively. The association between miR-27a-5p and APEX1 was determined by dual-luciferase reporter assay. Results: Isoginkgetin significantly suppressed A549 cell proliferative, migration and invasive activities (p < 0.05). Moreover, isoginkgetin significantly increased miR-27a-5p expression. Furthermore, miR-27a-5p suppressor annulled the influence of isoginkgetin on lung cancer progression. More importantly, the inhibitor directly targeted APEX1, and negatively modulated APEX1 expression (p < 0.05). However, APEX1 knockdown annulled the enhancing effect of miR-27a-5p inhibitor on A549 cell viability, migration and invasion (p < 0.05). Conclusion: Isoginkgetin exerts an anti-lung cancer effect via miR-27a-5p/APEX1 axis. Thus, it is a potential therapy for the management of lung cancer; however, clinical studies are required to validate these findings of this study.

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The Effect of Terpenoid Natural Chinese Medicine Molecular Compound on Lung Cancer Treatment

Cited by 7 publications

References 106 publications

The Most Potent Natural Pharmaceuticals, Cosmetics, and Food Ingredients Isolated from Plants with Deep Eutectic Solvents

The Most Potent Natural Pharmaceuticals, Cosmetics, and Food Ingredients Isolated from Plants with Deep Eutectic Solvents

Costs of traditional Chinese medicine treatment for inpatients with lung cancer in China: a national study

Isoginkgetin inhibits lung cancer cell progression through miR-27a-5p/APEX1 axis

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