The effect of the papillary renal cell carcinoma subtype on oncological outcomes

Pan, Honghong; Ye, Liefu; Zhu, Qingguo; Yang, Zhicong; Hu, Minxiong

doi:10.1038/s41598-020-78174-9

Cited by 30 publications

(16 citation statements)

References 18 publications

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“…As reported, PRCC accounted for approximately 10%–14% of RCC in Western population. However, the incidence of PRCC was reported to be approximately 5.2%–5.6% in Japanese and Korean populations and 1.9–7.5% in Chinese population ( 5 , 16 , 17 ). In this study, PRCC accounted for 4.3% of RCC, which was significantly lower than the incidence reported in the West, but a similar incidence was reported in Japan, Korea, and China.…”

Section: Discussionmentioning

confidence: 99%

The Clinicopathological Features and Prognosis in Patients With Papillary Renal Cell Carcinoma: A Multicenter Retrospective Study in Chinese Population

Hong

Hou²,

Chen³

et al. 2021

Front. Oncol.

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ObjectiveThe purpose of this study was to compare the clinicopathological characteristics of type 1 and type 2 papillary renal cell carcinoma (PRCC) and to explore the prognostic factors of PRCC in the Chinese population.MethodsA total of 242 patients with PRCC from five Chinese medical centers were retrospectively included. From them, 82 were type 1 PRCC and 160 were type 2 PRCC. Clinicopathological features and oncologic outcomes were reviewed. The Kaplan–Meier analysis and log-rank test were performed to describe the progression-free survival (PFS) and overall survival (OS). Univariate and multivariate Cox proportional hazards regression models were used to analyze the prognostic factors of PRCC.ResultsOf the 242 patients, the average age at surgery was 55.3 ± 13.1 years. The mean tumor size was 5.1 ± 3.1 cm. Compared with type 1 PRCC patients, type 2 PRCC patients had a larger tumor size and were more likely to undergo radical nephrectomy. Besides, type 2 PRCC patients had higher tumor stage (p < 0.001) and WHO International Society of Urological Pathology (WHO/ISUP) grading (p < 0.001). Furthermore, tumor necrosis was more common in type 2 PRCC than type 1 PRCC (p = 0.030). The Kaplan–Meier survival analysis showed that the PFS and OS of type 1 PRCC patients were significantly better than those of type 2 PRCC patients (p = 0.0032 and p = 0.0385, respectively). Univariate analysis showed that tumor size, surgical procedures, pT stage, WHO/ISUP grading, and microvascular invasion were significant predictors of PFS and OS for type 2 PRCC patients. In the multivariate analysis, only pT stage (p = 0.004) and WHO/ISUP grading (p = 0.010) were the independent risk factors. Among type 2 PRCC patients with pT1 stage, no significant difference was found in PFS and OS between the partial nephrectomy and radical nephrectomy groups (p = 0.159 and p = 0.239, respectively).ConclusionThis multi-institutional study reveals the significant differences in clinicopathological variables and oncologic outcomes between type 1 and 2 PRCC. For type 2 PRCC in pT1 stage, the prognosis of partial nephrectomy is not inferior to that of radical nephrectomy, and nephron-sparing surgery can be considered.

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Section: Discussionmentioning

confidence: 99%

The Clinicopathological Features and Prognosis in Patients With Papillary Renal Cell Carcinoma: A Multicenter Retrospective Study in Chinese Population

Hong

Hou²,

Chen³

et al. 2021

Front. Oncol.

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“…The characteristics of included studies are presented in Table 1 (3,(6)(7)(8)(9)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28). All included studies were in retrospective designs and were published between 2001 and 2020, and the patients were recruited ranged from 1970 to 2018.…”

Section: Study Selection and Characteristicsmentioning

confidence: 99%

Whether histologic subtyping affect the oncological outcomes of patients with papillary renal cell carcinoma: evidence from a systematic review and meta-analysis

Xiong¹,

Zhu²,

Li³

et al. 2021

Transl Androl Urol

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Background: Whether the histologic subtype (type 1 and type 2) of papillary renal cell carcinoma (pRCC) is a tool to predict the prognosis is of great debate. This study is aimed to evaluate the prognostic significance of histologic subtype in patients with pRCC after surgery through a systematic review and meta-analysis.Methods: We searched PubMed, the Web of Science, Cochrane library and EMBASE databases to identify studies published until January 20, 2021 according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Studies were deemed eligible if they compared the overall survival (OS), cancer specific survival (CSS), recurrence-free survival (RFS) or disease-free survival (DFS) between patients with type 1 or type 2 pRCC. And the corresponding hazard ratios (HRs) and 95% conference intervals (CIs) were collected for meta-analysis and further subgroup analysis.Results: Overall 22 studies with a total of 4,494 patients were considered eligible and included for the systematic review and meta-analysis. The pooled results showed that type 2 pRCC was associated with a worse

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“…Compared with type 1 PRCC, type 2 is more often associated with a greater stage, higher Fuhrman grade, higher frequency of necrosis and sarcomatoid features with worse outcome and more aggressive disease ( 18 , 26 ). However, previous studies indicated that WHO/ISUP grade and tumor size were associated with the prognosis, rather than histologic subtype ( 24 , 27 ). Based on preoperative imaging, this case was classified as Bosniak category IV and considered malignant.…”

Section: Discussionmentioning

confidence: 90%

Giant Polycystic Papillary Renal Cell Carcinoma: A Case Report and Literature Review

Huang,

Wang,

2022

Front. Oncol.

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IntroductionGiant, cystic renal tumors are generally considered relatively contraindicated for laparoscopic surgery. We report on a 19-year-old male, where polycystic lesions in the left kidney were accidentally noted by enhanced computed tomography (CT) by focusing on the diagnostic, clinical, and surgery to the patient.Case ReportEnhanced CT scan revealed solid component in multiple cystic lesions of Bosniak IV, which was enhanced after injection of contrast agent and the left kidney lost normal profile and enlarged with maximal diameter more than 18cm. Positron emission tomography-computed tomography (PET-CT) showed SUVmax 4.8 of the lesion and suggested malignant disease. A retroperitoneal laparoscopic radical left nephrectomy was performed successfully without cyst burst and the lesion was 17×17×18 cm in size. Pathological examination revealed that the lesions were consistent with papillary renal cell carcinoma (type 2, WHO grade II), no renal capsule invasion, no renal pelvis and renal sinus fat involvement, no abnormality in ureter and renal arteriovenous end, no abnormality in a few adrenal tissues, chronic inflammation of hilar lymph nodes (0/1). After surgery, no specific treatment was initiated and at a follow-up visit 1 year after surgery, no local recurrence or metastasis was found.ConclusionIt is the largest cystic renal cell carcinoma that has ever been reported for laparoscopic resection. The selection of surgery for giant cystic renal cell carcinoma should be individualized. Retroperitoneal laparoscopy may be an option for such lesions.

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The effect of the papillary renal cell carcinoma subtype on oncological outcomes

Cited by 30 publications

References 18 publications

The Clinicopathological Features and Prognosis in Patients With Papillary Renal Cell Carcinoma: A Multicenter Retrospective Study in Chinese Population

The Clinicopathological Features and Prognosis in Patients With Papillary Renal Cell Carcinoma: A Multicenter Retrospective Study in Chinese Population

Whether histologic subtyping affect the oncological outcomes of patients with papillary renal cell carcinoma: evidence from a systematic review and meta-analysis

Giant Polycystic Papillary Renal Cell Carcinoma: A Case Report and Literature Review

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