The effect of thyroid state, adrenaline and glucose on the release of free fatty acids from adipose tissue

Felt,; Schovanec, B; Beneš, P.; Plzák, F; Vrbensky,

doi:10.1007/bf02172262

Cited by 90 publications

(7 citation statements)

References 4 publications

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“…Hepatic triglyceride production was not diminished in severely hypothyroid subjects even though the plasma FFA levels were slightly less than in normal controls. This latter finding conforms with the observations on decreased sensitivity of adipose tissue of hypothyroid animals to lipolytic agents (30,50,51 The biochemical or hemodynamic basis of the deficient triglyceride removal in hypothyroidism remains to be determined. However, the close association observed here between the endogenous triglyceride fractional transport and the plasma PHLA in extreme cases of thyroid hyper-and hypofunction suggests that thyroid hormone is important for the synthesis of lipoprotein lipase and that the latter plays a central role in the elimination of.…”

Section: Plasma Triglyceride Metabolism In Thyroid Diseasesupporting

confidence: 89%

Plasma triglyceride metabolism in thyroid disease

Nikkilä¹,

Kekki²

1972

J. Clin. Invest.

216

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A B S T R A C T Plasma endogenous triglyceride transport kinetics were determined in 16 hyperthyroid and in 12 hypothyroid patients and the results compared with those of euthyroid control subjects. In addition, the removal of exogenous particulate fat (Intralipid; Vitrum, Sweden) from the circulation and the postheparin plasma lipolytic activity (PHLA) were studied in these patients for further characterization of the alterations of plasma triglyceride metabolism in thyroid disease.In thyrotoxicosis the average plasma triglyceride level was slightly but significantly increased above that of control subjects. This change was associated with augmented production of triglycerides whereas the mean fractional removal rate was not different from normal. There was a significant linear correlation between the concentration and turnover rate of plasma triglycerides in both hyperthyroid and euthyroid subjects but the concentration/turnover rate ratio was less in the former group suggesting that the efficiency of removal of triglycerides from the circulation was improved in thyroid hyperfunction. The elimination of intravenously administered particulate fat occurred more rapidly in untreated hyperthyroid patients than in euthyroid control subjects. The mean PHLA was also above normal in thyrotoxicosis. Upon adequate treatment of the hyperthyroid state the fasting plasma triglyceride concentration was further increased.Hypothyroid patients showed another pattern of alteration of triglyceride kinetics. The synthesis of plasma triglycerides was normal but the fractional removal of both endogenous and exogenous triglycerides was markedly reduced and this change seems to account for the hypertriglyceridemia associated with thyroid hypofunction. The plasma PHLA was also clearly decreased in the hypothyroid state.Plasma FFA and glycerol levels were increased in hyperthyroidism and plasma FFA was slightly deReceived for publication 17 January 1972 and in revised form 3 April 1972. creased in hypothyroid patients, but these variables were not significantly correlated with any parameter of triglyceride metabolism.Endogenous triglyceride turnover rate was significantly correlated with serum protein-bound iodine (PBI) and T3 uptake in thyrotoxicosis but not in hypothyroidism. Removal of exogenous fat was not related to postheparin plasma lipolytic activity but the fractional endogenous triglyceride transport showed a highly significant relationship to this lipase activity in a mixed group of hyper-and hypothyroid patients.The results suggest that thyroid hormones control both production and removal of plasma triglycerides.

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Section: Plasma Triglyceride Metabolism In Thyroid Diseasesupporting

confidence: 89%

Plasma triglyceride metabolism in thyroid disease

Nikkilä¹,

Kekki²

1972

J. Clin. Invest.

216

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“…The present studies confirm the potent lipolytic action of small concentrations of epinephrine in vitro, and are consistent with the finding of several investigators (17)(18)(19) that hypothyroidism decreases in vitro release of FFA from adipose tissue. adipose tissue of hypophysectomized dogs and rats.…”

supporting

confidence: 93%

Effect of Altered Thyroid Status upon Epinephrine Induced Lipolysis in vitro

Rosenfeld

Rosenberg

1965

Experimental Biology and Medicine

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“…Auch am isolierten Fettgewebe stimulieren die Schilddrüsenhormone die Lipolyse (DEBONS U. SCHWARTZ, und 1961HOFMANN etal, 1974a;JEANRENAUD, 1961;Löffler u. WEINGES, 1966;ROSENFELD U. ROSENBERG, 1965 VAUGHAN, 1963;FELT et al, 1962;HAGEN, 1960aHAGEN, und 1960bJEANRENAUD, 1961;LÖFFLER U. WEINGES, 1966;ROSENFELD U. ROSENBERG, 1965;ROSENQUIST, 1972 a und b;ROSENQUIST et al, 1971;SCHWARTZ U. DEBONS, 1959).…”

Section: C) Lipolyse Und Fettstoffwechselunclassified

Die Stoffwechselwirkungen der Schilddrüsenhormone

Dieterle¹,

Scriba²

1975

Diabetes Mellitus · A

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The effect of thyroid state, adrenaline and glucose on the release of free fatty acids from adipose tissue

Cited by 90 publications

References 4 publications

Plasma triglyceride metabolism in thyroid disease

Plasma triglyceride metabolism in thyroid disease

Effect of Altered Thyroid Status upon Epinephrine Induced Lipolysis in vitro

Die Stoffwechselwirkungen der Schilddrüsenhormone

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