The effect of titanium dioxide (TiO2) nano-objects, and their aggregates and agglomerates greater than 100 nm (NOAA) on microbes under UV irradiation

Yamada, Ikuho; Nomura, Kazuki; Iwahashi, Hitoshi; Horie, Masanori

doi:10.1016/j.chemosphere.2015.04.017

Cited by 13 publications

(4 citation statements)

References 7 publications

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“…TiO 2 NPs show antibacterial activity upon UV irradiation due to ROS generation by the process known as photocatalysis. The aggregates/agglomerates of TiO 2 NPs greater than 100 nm in diameter could not photo-inactivate E. coli and Saccharomyces cerevisiae , but conversely were able to act as a “sunscreen” and protect the microbial cells from inactivation by UV light alone [248, 249]. In one study, ZnO and TiO 2 NPs demonstrated a strong inhibition against some species of bacteria including MRSA biofilms [250].…”

Section: Nanotechnology For Treatment Of Burn Infections and Woundmentioning

confidence: 99%

Nanomedicine and advanced technologies for burns: Preventing infection and facilitating wound healing

Jahromi

Zangabad

Basri

et al. 2018

Advanced Drug Delivery Reviews

408

189

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According to the latest report from the World Health Organization, an estimated 265,000 deaths still occur every year as a direct result of burn injuries. A widespread range of these deaths induced by burn wound happens in low- and middle-income countries, where survivors face a lifetime of morbidity. Most of the deaths occur due to infections when a high percentage of the external regions of the body area is affected. Microbial nutrient availability, skin barrier disruption, and vascular supply destruction in burn injuries as well as systemic immunosuppression are important parameters that cause burns to be susceptible to infections. Topical antimicrobials and dressings are generally employed to inhibit burn infections followed by a burn wound therapy, because systemic antibiotics have problems in reaching the infected site, coupled with increasing microbial drug resistance. Nanotechnology has provided a range of molecular designed nanostructures (NS) that can be used in both therapeutic and diagnostic applications in burns. These NSs can be divided into organic and non-organic (such as polymeric nanoparticles (NPs) and silver NPs, respectively), and many have been designed to display multifunctional activity. The present review covers the physiology of skin, burn classification, burn wound pathogenesis, animal models of burn wound infection, and various topical therapeutic approaches designed to combat infection and stimulate healing. These include biological based approaches (e.g. immune-based antimicrobial molecules, therapeutic microorganisms, antimicrobial agents, etc.), antimicrobial photo- and ultrasound-therapy, as well as nanotechnology-based wound healing approaches as a revolutionizing area. Thus, we focus on organic and non-organic NSs designed to deliver growth factors to burned skin, and scaffolds, dressings, etc. for exogenous stem cells to aid skin regeneration. Eventually, recent breakthroughs and technologies with substantial potentials in tissue regeneration and skin wound therapy (that are as the basis of burn wound therapies) are briefly taken into consideration including 3D-printing, cell-imprinted substrates, nano-architectured surfaces, and novel gene-editing tools such as CRISPR-Cas.

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Section: Nanotechnology For Treatment Of Burn Infections and Woundmentioning

confidence: 99%

Nanomedicine and advanced technologies for burns: Preventing infection and facilitating wound healing

Jahromi

Zangabad

Basri

et al. 2018

Advanced Drug Delivery Reviews

408

189

View full text Add to dashboard Cite

show abstract

“…Thus, there are many reports that show titanium dioxide toxicity, especially nanoparticles of titanium dioxide, under light irradiation [ 10 ], with evidence of oxidative stress responses. We previously tried to detect the toxicity of anatase titanium dioxide nanoparticles under UV irradiation using microbes of the yeast Saccharomyces cerevisiae [ [11] , [12] ]. However, we could not detect the toxicity caused by ROS, but rather found oxidative stress caused by UV irradiation alone [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

“…However, we could not detect the toxicity caused by ROS, but rather found oxidative stress caused by UV irradiation alone [ 12 ]. Surprisingly, we observed a protective effect of titanium dioxide nanoparticles in UV irradiation [ 11 ]. Yeast cells were cultured on plate medium with titanium dioxide and we irradiated them with UV light.…”

Section: Introductionmentioning

confidence: 99%

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Titanium dioxide nanoparticles impart protection from ultraviolet irradiation to fermenting yeast cells

Ono

Iwahashi

2022

Biochemistry and Biophysics Reports

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Dispersion stability of titanium dioxide in aqueous isopropanol with polymer dispersant

et al. 2020

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The effect of titanium dioxide (TiO2) nano-objects, and their aggregates and agglomerates greater than 100 nm (NOAA) on microbes under UV irradiation

Cited by 13 publications

References 7 publications

Nanomedicine and advanced technologies for burns: Preventing infection and facilitating wound healing

Nanomedicine and advanced technologies for burns: Preventing infection and facilitating wound healing

Titanium dioxide nanoparticles impart protection from ultraviolet irradiation to fermenting yeast cells

Dispersion stability of titanium dioxide in aqueous isopropanol with polymer dispersant

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