The effect of topical piperine combined with narrowband <scp>UVB</scp> on vitiligo treatment: A clinical trial study

Shafiee, Anoosh; Hoormand, Mahmood; Shahidi‐Dadras, Mohammad; Abadi, Ashraf H.

doi:10.1002/ptr.6116

Cited by 23 publications

(17 citation statements)

References 28 publications

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“…(1) e main power supply in the printed circuit board needs to be close to the ground plane, which is beneficial in shortening the power return path, reduce power loss, and reduce electromagnetic interference [11,12] (2) e high-speed signal layer must be close to the plane layer, preferably the ground plane layer, which can also shorten the return path, reduce signal attenuation, and have a shielding effect (3) e laminated design needs to be symmetrical to each other to avoid warping and deformation of the PCB board (4) e signal layer cannot be directly adjacent to each other; otherwise, it is easy to cause crosstalk and cause circuit function failure (5) Important signal lines need to be routed in the inner layer, preferably surrounded by two ground layers By consulting some common laminated design knowledge, and taking into account the practical application requirements of this article, in order to fully meet the electromagnetic compatibility and signal integrity of the video recorder of medical ultrasound equipment, this article uses a ten-layer PCB laminated structure to avoid the aforementioned inaccurate audio and video information due to factors such as immunity and sensitivity and also provide a guarantee for subsequent layout.…”

Section: Pcb Design and Implementationmentioning

confidence: 99%

“…. (12) e use of the mutual information method for registration is based on the following assumption: when two images are perfectly aligned, the total amount of information they contain should be the largest; that is, the mutual information is the largest. It can be seen from the above formula that maximizing mutual information and minimizing joint entropy are essentially the same.…”

Section: Measurement Criteriamentioning

confidence: 99%

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Design and Implementation of a Heating Treatment System for Vitiligo Skin Disease Based on Medical Ultrasound

Gao

Tian

Lyu

et al. 2021

Journal of Healthcare Engineering

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Vitiligo is relatively common clinically. It is an acquired and persistent skin and mucosal pigment depigmentation disease. As a noninvasive and nonradioactive treatment, high-energy ultrasound has been applied to skin diseases of vitiligo. Treatment achieved good clinical results. This article analyzes the structure of the original medical ultrasound system for vitiligo and finds the deficiencies and missing components of the system. On the basis of the original design scheme, a new structural scheme was designed, which solved the shortcomings of the original system and added missing parts. Subsequently, according to actual application requirements and specific component performance, the schematic design, including audio and video input, output and storage, DDR3, Ethernet, and the design of key circuits, such as power supply modules, are specifically introduced. Later, in the PCB design, the contents including stacking, layout, routing, and simulation of key signals were introduced in detail. The design includes a probe excitation signal generation module, excitation signal parameter control module, high voltage and temperature monitoring module, and corresponding power conversion module. This paper is mainly to develop a vitiligo skin disease heating treatment array system based on the principle of both cost and performance. This paper is based on the nonrigid registration algorithm of the FFD model and HPV interpolation and the nonrigid registration algorithm combining shape information and SIFT method. In the focused ultrasound treatment system, the image-guided positioning and monitoring functions are realized. Studies have shown that when the peak voltage of the transmitter circuit is 55 V, the sound power is 0.28 W. It can be seen that the transmitting circuit system designed in this article is a relatively stable and reliable system, which is suitable for the ultrasound treatment of vitiligo skin diseases.

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Section: Pcb Design and Implementationmentioning

confidence: 99%

Section: Measurement Criteriamentioning

confidence: 99%

Design and Implementation of a Heating Treatment System for Vitiligo Skin Disease Based on Medical Ultrasound

Gao

Tian

Lyu

et al. 2021

Journal of Healthcare Engineering

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“…Two clinical trials have evaluated the effect of topical piperine on vitiligo treatment and found positive effects (Table 2). In patients with facial vitiligo, topical treatment with piperine combined with narrowband UVB (NB-UVB) therapy resulted in significantly higher repigmentation rate at time intervals of 1, 2, and 3 months after treatment than in the control group [182]. In another study [183], a Piper nigrum fruit extract and pure piperine were integrated into different ointments and applied for 12 weeks to different skin areas of the vitiligo patients.…”

Section: Vitiligomentioning

confidence: 99%

Piperine-A Major Principle of Black Pepper: A Review of Its Bioactivity and Studies

et al. 2019

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Piperine is the main compound present in black pepper, and is the carrier of its specific pungent taste, which is responsible for centuries of human dietary utilization and worldwide popularity as a food ingredient. Along with the application as a food ingredient and food preservative, it is used in traditional medicine for many purposes, which has in most cases been justified by modern scientific studies on its biological effects. It has been confirmed that piperine has many bioactive effects, such as antimicrobial action, as well as many physiological effects that can contribute to general human health, including immunomodulatory, hepatoprotective, antioxidant, antimetastatic, antitumor, and many other activities. Clinical studies demonstrated remarkable antioxidant, antitumor, and drug availability-enhancing characteristics of this compound, together with immunomodulatory potential. All these facts point to the therapeutic potential of piperine and the need to incorporate this compound into general health-enhancing medical formulations, as well as into those that would be used as adjunctive therapy in order to enhance the bioavailability of various (chemo)therapeutic drugs.

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“…The clinical trials completed are 11 and in addition that are currently ongoing are 5; a total of 1002 articles have been published on piperine in the last 10 years (Table 2 and Fig. 2 ) [ 12 – 15 ]. However, some of the clinical trial data is published but not registered.…”

Section: Introductionmentioning

confidence: 99%

Molecular and pharmacological aspects of piperine as a potential molecule for disease prevention and management: evidence from clinical trials

Tripathi

Ray

Mishra

2022

Beni-Suef Univ J Basic Appl Sci

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Background Piperine is a type of amide alkaloid that exhibits pleiotropic properties like antioxidant, anticancer, anti-inflammatory, antihypertensive, hepatoprotective, neuroprotective and enhancing bioavailability and fertility-related activities. Piperine has the ability to alter gastrointestinal disorders, drug-metabolizing enzymes, and bioavailability of several drugs. The present review explores the available clinical and preclinical data, nanoformulations, extraction process, structure–activity relationships, molecular docking, bioavailability enhancement of phytochemicals and drugs, and brain penetration properties of piperine in the prevention, management, and treatment of various diseases and disorders. Main body Piperine provides therapeutic benefits in patients suffering from diabetes, obesity, arthritis, oral cancer, breast cancer, multiple myeloma, metabolic syndrome, hypertension, Parkinson's disease, Alzheimer’s disease, cerebral stroke, cardiovascular diseases, kidney diseases, inflammatory diseases, and rhinopharyngitis. The molecular basis for the pleiotropic activities of piperine is based on its ability to regulate multiple signaling molecules such as cell cycle proteins, anti-apoptotic proteins, P-glycoprotein, cytochrome P450 3A4, multidrug resistance protein 1, breast cancer resistance protein, transient receptor potential vanilloid 1 proinflammatory cytokine, nuclear factor-κB, c-Fos, cAMP response element-binding protein, activation transcription factor-2, peroxisome proliferator-activated receptor-gamma, Human G-quadruplex DNA, Cyclooxygenase-2, Nitric oxide synthases-2, MicroRNA, and coronaviruses. Piperine also regulates multiple signaling pathways such as Akt/mTOR/MMP-9, 5′-AMP-activated protein kinase-activated NLR family pyrin domain containing-3 inflammasome, voltage-gated K+ current, PKCα/ERK1/2, NF-κB/AP-1/MMP-9, Wnt/β-catenin, JNK/P38 MAPK, and gut microbiota. Short conclusion Based on the current evidence, piperine can be the potential molecule for treatment of disease, and its significance of this molecule in the clinic is discussed. Graphical abstract

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The effect of topical piperine combined with narrowband UVB on vitiligo treatment: A clinical trial study

Cited by 23 publications

References 28 publications

Design and Implementation of a Heating Treatment System for Vitiligo Skin Disease Based on Medical Ultrasound

Design and Implementation of a Heating Treatment System for Vitiligo Skin Disease Based on Medical Ultrasound

Piperine-A Major Principle of Black Pepper: A Review of Its Bioactivity and Studies

Molecular and pharmacological aspects of piperine as a potential molecule for disease prevention and management: evidence from clinical trials

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