The Effect of Treadmill Exercise on Ischemic Neuronal Injury in the Stroke Animal Model: Potentiation of Cerebral Vascular Integrity

Kang, Kyoung Ah; Seong, Hohyun; Jin, Han-Byeol; Park, Jong-Min; Lee, Jongmin; Jeon, Jae Yong; Kim, Youn Jung

doi:10.4040/jkan.2011.41.2.197

Cited by 8 publications

(3 citation statements)

References 23 publications

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“…Exercise also benefits the nervous system. It is reported that exercise enhances cerebral vascular integrity (Kang et al, 2011), promotes hippocampal neurogenesis , and modulates cognitive benefits (Lebowitz et al, 2018). Furthermore, exercise alleviates ischemiainduced memory impairment (Seo et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Voluntary exercise promotes neurotrophic factor and suppresses apoptosis in hippocampal ischemia

2019

J. Integr. Neurosci.

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J o u r n a l o f I n t e g r a t i v e N e u r o s c i e n c eThis is an open access article under the CC BY-NC 4.0 license (https://creativecommons.org/licenses/by-nc/4.0/) Previous studies have demonstrated that exercise facilitates recovery from ischemia. However, the mechanisms need to be further elucidated. The current investigation was designed to study the effect of voluntary exercise on cerebral ischemia and discuss possible mechanisms usingmiddle cerebral artery occlusion model. Rats were randomly allocated to three groups: control, middle cerebral artery occlusion, and middle cerebral artery occlusion plus exercise. The middle cerebral artery occlusion plus exercise group was preconditioned by three weeks of voluntary wheel running prior to surgery. The accelerated rotarod test was employed to evaluate motor performance. Infarct volumes were analyzed to detect the neuroprotective effect of voluntary exercise. Brain-derived neurotrophic factor, Bax, Bcl-2, and caspase-3 protein expressions were measured by Western blot. Behavior evaluation showed the middle cerebral artery occlusion plus exercise group achieved significantly longer time on a rotarod than the unexercised group. Additionally, voluntary exercise reduced cerebral infarction and increased brain derived neurotrophic factor expression. Exercise downregulated the apoptotic Bax/Bcl-2 ratio and caspase-3 protein expression. Results indicate that voluntary wheel running promote hippocampal brain derived neurotrophic factor and inhibit cell apoptosis in ischemia-induced impairment. KeywordsHippocampal ischemia; voluntary exercise; brain-derived neurotrophic factor; apoptosis; rodent Abbreviations BDNF Brain-derived neurotrophic factor CCA Common carotid artery ECA External carotid artery ICA Internal carotid artery MCA Middle cerebral artery MCAO Middle cerebral artery occlusion TTC 2,3,5-Triphenyl-tetrazolium chloride solution

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Section: Discussionmentioning

confidence: 99%

Voluntary exercise promotes neurotrophic factor and suppresses apoptosis in hippocampal ischemia

2019

J. Integr. Neurosci.

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“…Furthermore, by doing these exercises, the amount of pro-inflammatory factors can be reduced to protect against cerebral ischemia-reperfusion injury [64] . It can also reduce ischemic brain damage by enhancing microvascular integrity after cerebral ischemia [65] . Prolonged exercise on a treadmill can also cause molecular neuroprotective changes in the rat brain [66] .…”

Section: Improving Musclementioning

confidence: 99%

Treadmill Exercise and its Effect on Rehabilitation of Patients after Ischemic strok: A Narrative Study

Motaqi

Ghanjal²,

Afrand³

2022

IJMPP

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Aim: Stroke is the third leading cause of death after cardiovascular disease and cancer. Stroke causes disability in various forms in sufferers. It has been suggested that various pathological mechanisms are involved in causing this injury. Articles show that regular exercise is a way to treat stroke patients. One of the most common exercise therapy models is treadmill exercise. However, there is still controversy about when to start treadmill workouts, the intensity of the workout, the type of treadmill workout, and how it has positive effects. This article offers an overview of treadmill exercise and its' effects on post-ischemic stroke rehabilitation. In this study, the effect of exercise time, exercise intensity, exercise style, and the positive effects of this type of exercise on rehabilitation of patients after ischemic stroke were briefly examined.

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“…In addition, exercise preconditioning is a special neuronal IPC, which may induce brain tolerance to ischemia, enhance neuroprotection and resist a series of brain damages caused by ischemia (110,111). Previous studies have demonstrated that exercise pretreatment 3 weeks before stroke improves the structural integrity of the brain microvascular structure in rats (112)(113)(114). This effect may be related to HIF-1α.…”

Section: Role Of Hif-1α In Cerebral Ischemic Preconditioning (Ipc)mentioning

confidence: 99%

HIF‑1α in cerebral ischemia (Review)

Dong

Han

2021

Mol Med Rep

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Cerebral ischemic injury may lead to a series of serious brain diseases, death or different degrees of disability. Hypoxia-inducible factor-1α (HIF-1α) is an oxygen-sensitive transcription factor, which mediates the adaptive metabolic response to hypoxia and serves a key role in cerebral ischemia. HIF-1α is the main molecule that responds to hypoxia. HIF-1α serves an important role in the development of cerebral ischemia by participating in numerous processes, including metabolism, proliferation and angiogenesis. The present review focuses on the endogenous protective mechanism of cerebral ischemia and elaborates on the role of HIF-1α in cerebral ischemia. In addition, it focuses on cerebral ischemia interventions that act on the HIF-1α target, including biological factors, non-coding RNA, hypoxic-ischemic preconditioning and drugs, and expands upon the measures to strengthen the endogenous compensatory response to support HIF-1α as a therapeutic target, thus providing novel suggestions for the treatment of cerebral ischemia. Contents1. Introduction 2. Literature screening method 3. Role of HIF-1α in cerebral ischemia 4. HIF-1α protects the brain via the regulation of endogenous substances 5. Role of HIF-1α in cerebral ischemic preconditioning (IPC) 6. Role of HIF-1α in the protective effects of natural compounds against cerebral ischemia 7. Concluding remarks and future perspectives

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The Effect of Treadmill Exercise on Ischemic Neuronal Injury in the Stroke Animal Model: Potentiation of Cerebral Vascular Integrity

Cited by 8 publications

References 23 publications

Voluntary exercise promotes neurotrophic factor and suppresses apoptosis in hippocampal ischemia

Voluntary exercise promotes neurotrophic factor and suppresses apoptosis in hippocampal ischemia

Treadmill Exercise and its Effect on Rehabilitation of Patients after Ischemic strok: A Narrative Study

HIF‑1α in cerebral ischemia (Review)

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