The effect of type 2 diabetes on electrocardiographic markers of significant cardiac events

Kuzu, Fatih

doi:10.12669/pjms.343.14562

Cited by 15 publications

(11 citation statements)

References 25 publications

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“…However, other researchers have found different results. In DM patients with CAN, QTc was significantly higher than those without CAN [25] and prolonged QTc had direct relation to the severity of CAN [26]. The sample size and mean age of their patients were lower and their BMI and glycosylated hemoglobin were higher compare to our study.…”

Section: Long Qt and Cancontrasting

confidence: 74%

The relationship between QT interval indices with cardiac autonomic neuropathy in diabetic patients: a case control study

Vasheghani

Sarvghadi

Beyranvand

et al. 2020

Diabetol Metab Syndr

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Background Long QT interval (QT) and abnormal QT dispersion (QTd) are associated with sudden death. The relationship between cardiac autonomic neuropathy (CAN) and QT indices in type 2 diabetic patients were investigated. Methods Totally 130 diabetic subjects (mean age 50.87 ± 13.9 years) were included (70 individuals with and 60 individuals without CAN). All participants had sinus cardiac rhythm. The patients who had diseases or take drugs that cause orthostatic hypotension (OH), cardiac arrhythmia and QT prolongation were excluded. After interview and examination, standard and continuous ECG was taken in supine position with deep breathing and standing up position. CAN diagnosis was based on Ewing’s tests. QT, QT corrected (QTc), minimum QT (QT min), maximum QT (QT max) and mean ± SD of QT (QT mean) and QTd were assessed from standard ECG. QTc was calculated by Bazett’s formula from V2 lead. QTc > 440 ms in men and QTc > 460 ms in women and QTd > 80 ms were considered abnormal. Results In patients with CAN, 21.5% were symptomatic. The prevalence of abnormal QTc and QTd was 11.3% and 28.7%, respectively. There was no significant difference between the patients with or without CAN in terms of long QTc and abnormal QTd. However, the mean ± SD of QT max, QT mean and QTd was higher in the patients with CAN (P value < 0.03). The used cut points for QTc and QTd have high specificity (79% for both) and low sensitivity (30% and 37%, respectively). To use QTc and QTd as screening test for CAN in T2DM patients, the cutoff points 380 and 550 ms are suggested, respectively. Conclusion The prevalence of asymptomatic CAN was 3.7 times that of symptomatic CAN. In patients with CAN the QT max, QT mean and QTd were higher than those without CAN. There was no association between CAN and long QTc and abnormal QTd.

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Section: Long Qt and Cancontrasting

confidence: 74%

The relationship between QT interval indices with cardiac autonomic neuropathy in diabetic patients: a case control study

Vasheghani

Sarvghadi

Beyranvand

et al. 2020

Diabetol Metab Syndr

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“…As a test with a high prediction value, it can be used to predict the chance of CVD development. 14 It is worth noting that the majority of studies have investigated the effects of MetS only on one or few markers from the patients’ electrocardiograms, such as aortic stiffness, 15 T-wave axis, 16 , 17 resting heart rate, 18 QT interval, ST segment, and Q-wave, 14 or assessed the effect of only one component of the MetS, such as blood glucose, 19 , 20 obesity, 21 and/or abdominal adiposity 22 on the majority of ECG markers. This suggests that there are few similar studies in the world and no similar study in Iran as comprehensive as the present study.…”

Section: Introductionmentioning

confidence: 99%

<p>The Association of Metabolic Syndrome and Its Components with Electrocardiogram Parameters and Abnormalities Among an Iranian Rural Population: The Fasa PERSIAN Cohort Study</p>

Yazdanpanah¹,

Sayyadipoor²,

Hojati³

et al. 2020

DMSO

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Background: Metabolic syndrome (MetS) as a set of cardiac risk factors and its growing prevalence is one of the major concerns in different societies. In this study, we aimed to investigate the relationship between Mets and electrocardiogram (ECG) parameters and abnormalities as indicators for subclinical cardiovascular diseases (CVD). Methods: In this sub-analysis study, we used the data from Fasa PERSIAN Cohort Study which includes subjects age 35-70 years. Subjects with available ECG data included in the study (n=7002) and subjects with missing data on MetS components and non-sinus rhythm ECG were excluded (n=44). The MetS definition based on the Adult Treatment Panel (ATP) III guidelines and also a 12-lead ECG was obtained from all participants. Results: Our study population (n=6958) showed a mean age of 48.60±9.34 years and also 1656 (24.2%) subjects had MetS. Except for P duration, PR interval and S amplitude in men and P amplitude, S amplitude, Sokolow-Lyon Index, and QT interval in women, other ECG parameters differ significantly between subjects with and without Mets (P<0.05). Also among ECG abnormalities, prolonged P duration (≥120ms), QRS duration (≥100ms), and QTc interval (>450ms in male, >470ms in female) had a significant association with MetS in the total population. Waist circumferences (WC) showed the most count of significant relationship with ECG parameters in both genders. In males, WC more than ATP cut-points had significant associations with prolonged P and QRS duration, and also blood pressure (BP) had significant associations with prolonged P and QRS durations and QTc interval. In females, the MetS component except triglyceride had at least a significant relationship with prolonged P and/or QRS duration. Conclusion: MetS and its component especially WC and BP were associated with ECG parameters and abnormalities. These associations with ECG as a marker of subclinical CVD showed the importance of MetS and each component in our population to monitor in the further longitudinal studies.

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“…23,24 However, other researchers have found different results. In DM patients with CAN, QTc was signi cantly higher than those without CAN 25 and prolonged QTc had direct relation to the severity of CAN. 26 The sample size and mean age of their patients were lower and their BMI and glycosylated hemoglobin were higher compare to our study.…”

Section: Long Qt and Dmmentioning

confidence: 86%

The Relationship between QT Interval Indices with Cardiac Autonomic Neuropathy in Diabetic Patients- A casecontrol_ study

vasheghani

Sarvghadi

Beyranvand

et al. 2020

Preprint

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Background: Long QT interval (QT) and abnormal QT dispersion (QTd) are associated with sudden death. The relationship between cardiac autonomic neuropathy (CAN) and QT indices in type 2 diabetic patients were investigated. Methods: Totally 130 diabetic subjects (mean age 50.87 ± 13.9 years) were included (70 individuals with and 60 individuals without CAN). All participants had sinus cardiac rhythm. The patients who had diseases or take drugs that cause orthostatic hypotension (OH), cardiac arrhythmia and QT prolongation were excluded. After interview and examination, standard and continuous ECG was taken in supine position with deep breathing and standing up position. CAN diagnosis was based on Ewing’s tests. QT, QT corrected (QTc), minimum QT (QT min), maximum QT (QT max) and mean ± SD of QT (QT mean) and QTd were assessed from standard ECG. QTc was calculated by Bazett’s formula from V2 lead. QTc > 440 msec in men and QTc > 0.46 msec in women and QTd > 80 msec were considered abnormal.Results: In patients with CAN, 21.5% were symptomatic. The prevalence of abnormal QTc and QTd was 11.3% and 28.7%, respectively. There was no significant difference between the patients with or without CAN in terms of long QTc and abnormal QTd. However, the mean ± SD of QT max, QT mean and QTd was higher in the patients with CAN (P value <0.03). The used cut points for QTc and QTd have high specificity (79% for both) and low sensitivity (30% and 37%, respectively). To use QTc and QTd as screening test for CAN in T2DM patients, the cutoff points 380 and 550 msec are suggested, respectively. Conclusion: The prevalence of asymptomatic CAN was 3.7 times that of symptomatic CAN. In patients with CAN the QT max, QT mean and QTd were higher than those without CAN .There was no association between CAN and long QTc and abnormal QTd.

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The effect of type 2 diabetes on electrocardiographic markers of significant cardiac events

Cited by 15 publications

References 25 publications

The relationship between QT interval indices with cardiac autonomic neuropathy in diabetic patients: a case control study

The relationship between QT interval indices with cardiac autonomic neuropathy in diabetic patients: a case control study

<p>The Association of Metabolic Syndrome and Its Components with Electrocardiogram Parameters and Abnormalities Among an Iranian Rural Population: The Fasa PERSIAN Cohort Study</p>

The Relationship between QT Interval Indices with Cardiac Autonomic Neuropathy in Diabetic Patients- A casecontrol_ study

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