The effect of Vaccinium uliginosum on rabbit retinal structure and light-induced function damage

Yin, Lan; Pi, Yuli; Zhang, Maonian

doi:10.1007/s11655-011-0901-1

Cited by 8 publications

(5 citation statements)

References 14 publications

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“…Experimental studies in ophthalmology are often performed on the eyes of rabbits due to their similar size and the ease of making clinical observations without additional specialized equipment [ 63 , 64 ]. On the other hand, the rabbit retina has significant differences from the human retina (merangiotic type of the retina, absence of the macular area, and different distribution of photoreceptors of various types) [ 65 , 66 ].…”

Section: Discussionmentioning

confidence: 99%

OculusGraphy: Signal Analysis of the Electroretinogram in a Rabbit Model of Endophthalmitis Using Discrete and Continuous Wavelet Transforms

et al. 2023

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Background: The electroretinogram is a clinical test used to assess the function of the photoreceptors and retinal circuits of various cells in the eye, with the recorded waveform being the result of the summated response of neural generators across the retina. Methods: The present investigation involved an analysis of the electroretinogram waveform in both the time and time–frequency domains through the utilization of the discrete wavelet transform and continuous wavelet transform techniques. The primary aim of this study was to monitor and evaluate the effects of treatment in a New Zealand rabbit model of endophthalmitis via electroretinogram waveform analysis and to compare these with normal human electroretinograms. Results: The wavelet scalograms were analyzed using various mother wavelets, including the Daubechies, Ricker, Wavelet Biorthogonal 3.1 (bior3.1), Morlet, Haar, and Gaussian wavelets. Distinctive variances were identified in the wavelet scalograms between rabbit and human electroretinograms. The wavelet scalograms in the rabbit model of endophthalmitis showed recovery with treatment in parallel with the time-domain features. Conclusions: The study compared adult, child, and rabbit electroretinogram responses using DWT and CWT, finding that adult signals had higher power than child signals, and that rabbit signals showed differences in the a-wave and b-wave depending on the type of response tested, while the Haar wavelet was found to be superior in visualizing frequency components in electrophysiological signals for following the treatment of endophthalmitis and may give additional outcome measures for the management of retinal disease.

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Section: Discussionmentioning

confidence: 99%

OculusGraphy: Signal Analysis of the Electroretinogram in a Rabbit Model of Endophthalmitis Using Discrete and Continuous Wavelet Transforms

et al. 2023

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“…It has been recently reported that Vaccinium uliginosum extract prevented the blue light-induced human retinal pigment epithelial cell death by inhibiting photo-oxidation of N-retinyl-N-retinylidene ethanolamine [ 37 ]. Extract of V. uliginosum partially preserved the outer nuclear layer of retina after light damage [ 19 ]. Another study reported the positive effect of V. uliginosum extract on improving learning and memory impairment in murine Alzheimer’s disease model [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

“…Antioxidants supplementation has been known as effective in alleviating dry eye symptoms [ 16 – 18 ]. In addition, the extract of Vaccinium uliginosum demonstrated protective effect of retinal cells in light-induced retinal damage [ 19 ]. Considering its antioxidative constituents and previous evidences of retinal protection, we hypothesize that the extract of Vaccinium uliginosum will be useful in treating various ocular pathologies including computer vision syndrome.…”

Section: Introductionmentioning

confidence: 99%

The effect of Vaccinium uliginosum extract on tablet computer-induced asthenopia: randomized placebo-controlled study

Park

Lim

et al. 2016

BMC Complement Altern Med

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BackgroundTo investigate the alleviation effect of Vaccinium uliginosum extract (DA9301) on tablet computer-induced asthenopia.MethodsThis was a randomized, placebo-controlled, double-blind and parallel study (Trial registration number: 2013–95). A total 60 volunteers were randomized into DA9301 (n = 30) and control (n = 30) groups. The DA9301 group received DA9301 oral pill (1000 mg/day) for 4 weeks and the control group received placebo. Asthenopia was evaluated by administering a questionnaire containing 10 questions (responses were scored on a scales of 0–6; total score: 60) regarding ocular symptoms before (baseline) and 4 weeks after receiving pills (DA9301 or placebo). The participants completed the questionnaire before and after tablet computer (iPad Air, Apple Inc.) watching at each visit. The change in total asthenopia score (TAS) was calculated and compared between the groupsResultsTAS increased significantly after tablet computer watching at baseline in DA9301 group. (from 20.35 to 23.88; p = 0.031) However, after receiving DA9301 for 4 weeks, TAS remained stable after tablet computer watching. In the control group, TAS changes induced by tablet computer watching were not significant both at baseline and at 4 weeks after receiving placebo. Further analysis revealed the scores for “tired eyes” (p = 0.001), “sore/aching eyes” (p = 0.038), “irritated eyes” (p = 0.010), “watery eyes” (p = 0.005), “dry eyes” (p = 0.003), “eye strain” (p = 0.006), “blurred vision” (p = 0.034), and “visual discomfort” (p = 0.018) significantly improved in the DA9301 group.ConclusionsWe found that oral intake of DA9301 (1000 mg/day for 4 weeks) was effective in alleviating asthenopia symptoms induced by tablet computer watching.Trial registrationThe study is registered at www.clinicaltrials.gov (registration number: NCT02641470, date of registration December 30, 2015).

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“…Researchers demonstrated that V. uliginosum extracts protected retinal cells from lightinduced damage [84]. One study investigated the protective action of anthocyanins isolated from V. uliginosum on retinal cells against damage caused by microwave radiation.…”

Section: Ophthalmologymentioning

confidence: 99%

Vaccinium uliginosum and Vaccinium myrtillus—Two Species—One Used as a Functional Food

Kopystecka,

Kozioł,

Radomska

et al. 2023

Nutrients

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Vaccinium uliginosum L. (commonly known as bog bilberry) and Vaccinium myrtillus L. (commonly known as bilberry) are species of the genus Vaccinium (family Ericaceae). The red–purple–blue coloration of blueberries is attributed largely to the anthocyanins found in bilberries. Anthocyanins, known for their potent biological activity as antioxidants, have a significant involvement in the prophylaxis of cancer or other diseases, including those of metabolic origin. Bilberry is the most important economically wild berry in Northern Europe, and it is also extensively used in juice and food production. A review of the latest literature was performed to assess the composition and biological activity of V. uliginosum and V. myrtillus. Clinical studies confirm the benefits of V. uliginosum and V. myrtillus supplementation as part of a healthy diet. Because of their antioxidant, anti-inflammatory, anti-cancer, and apoptosis-reducing activity, both bog bilberries and bilberries can be used interchangeably as a dietary supplement with anti-free radical actions in the prevention of cancer diseases and cataracts, or as a component of sunscreen preparations.

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The effect of Vaccinium uliginosum on rabbit retinal structure and light-induced function damage

Abstract: VU can relieve the injury to rabbit retinae exposed to normal day and night rhythm, alleviate the harm caused by light when used beforehand, and repair the light damage to the retina.

Cited by 8 publications

References 14 publications

OculusGraphy: Signal Analysis of the Electroretinogram in a Rabbit Model of Endophthalmitis Using Discrete and Continuous Wavelet Transforms

OculusGraphy: Signal Analysis of the Electroretinogram in a Rabbit Model of Endophthalmitis Using Discrete and Continuous Wavelet Transforms

The effect of Vaccinium uliginosum extract on tablet computer-induced asthenopia: randomized placebo-controlled study

Vaccinium uliginosum and Vaccinium myrtillus—Two Species—One Used as a Functional Food

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