The effect of VDR gene polymorphisms and vitamin D level on blood pressure, risk of preeclampsia, gestational age, and body mass index

Rezavand, Negin; Tabarok, Saba; Rahimi, Ziba; Vaisi‐Raygani, Asad; Mohammadi, Ehsan; Rahimi, Zohreh

doi:10.1002/jcb.27934

Cited by 42 publications

(45 citation statements)

References 23 publications

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“…The C allele of VDR FokI polymorphism does not have the rst ATG, and translation starts at the second ATG. So, the presence of this allele producing a shorter VDR protein by 3 amino acids compared with the T allele (10). In the present study, signi cantly higher frequency of the FokI C allele was detected in SS and S/β thal patients than controls.…”

Section: Discussionsupporting

confidence: 51%

“…The phenol-chloroform method was used for the extraction of DNA from the leukocyte of the EDTA-treated whole blood (9). The FokI T>C (rs2228570) in exon 2 and the TaqI T>C (rs731236) in exon 9 of the VDR gene were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method as previously described (10). The GC rs7041 was identi ed by the PCR-RFLP method using the HaeIII restriction enzyme (7).…”

Section: Genotypingmentioning

confidence: 99%

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Vitamin D level, lipid profile, and vitamin D receptor and transporter gene variants in sickle cell disease patients from Kurdistan of Iraq

Hama

Shakiba

Rahimi

et al. 2021

Preprint

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Background. Sickle cell disease patients are susceptible to the development of vitamin D deficiency. Vitamin D through binding to vitamin receptor (VDR) exerts its function and affects gene transcription in target tissues. Also, VDR variants could affect bone mineral density. Methods. In a case-control study 101 sickle cell disease patients including 61 SS, 39 S/β-thalassemia, and 1 SD along with 110 healthy individuals from Kurdistan of Iraq were studied. The lipid profile, vitamin D level, FokI, and TaqI variants of VDR and group-specific component (GC) were detected using the standard enzymatic method, the immunodiagnostic systems limited EIA kit and PCR-RFLP methods, respectively. Results. Around 93 and 82% SS and S/β thalassemia patients, respectively had vitamin D deficiency compared to 83% healthy individuals. Severe vitamin D deficiency (<10 ng/ml) was detected in 78.7% of SS patients. Plasma levels of total cholesterol, HDL-C, and LDL-C in SCD patients were significantly lower compared to controls. Vitamin D levels were negatively correlated to TG and positively correlated to total cholesterol and HDL-C. The frequencies of the C allele of FokI were 81.7 (p=0.003), 80.2 (p=0.034), and 84.6% (p=0.011) in all SCD, SS, and SS/βthal patients, respectively compared to 69.1% in controls. However, no significant difference was detected by comparing the frequencies of VDR TaqI and GC polymorphisms between SCD patients and controls.Conclusion. In the present study we found hypocholesterolemia, high prevalence of VDR FokI C allele, and low vitamin D level among children and adults with SCD patients from Kurdistan of Iraq.

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Section: Discussionsupporting

confidence: 51%

Section: Genotypingmentioning

confidence: 99%

Vitamin D level, lipid profile, and vitamin D receptor and transporter gene variants in sickle cell disease patients from Kurdistan of Iraq

Hama

Shakiba

Rahimi

et al. 2021

Preprint

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“…That PE is characterized by defective placentation at early stages of pregnancy and that hypovitaminosis D is frequently found in women with PE, suggest a potential role for vitamin D as a crucial molecule in normal placentation. An association between VDR FokI polymorphism and the risk of PE has also been reported, suggesting that the interaction of vitamin D with its receptor is required for placenta development and function (139). It has also been suggested that low levels of vitamin D may disrupt the immune balance leading to overexpression of Th1 cytokines and failure of immunological tolerance toward embryo implantation (133).…”

Section: The Role Of Vitamin D In Pregnancy: From Conception To Partumentioning

confidence: 99%

Immunomodulatory Effects of Vitamin D in Pregnancy and Beyond

Cyprian

Lefkou²,

Varoudi³

et al. 2019

Front. Immunol.

130

100

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In addition to its role in calcium homeostasis and bone formation, a modulatory role of the active form of vitamin D on cells of the immune system, particularly T lymphocytes, has been described. The effects of vitamin D on the production and action of several cytokines has been intensively investigated in recent years. In this connection, deficiency of vitamin D has been associated with several autoimmune diseases, including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), antiphospholipid syndrome (APS), Hashimoto Thyroiditis (HT), and multiple sclerosis (MS). In a successful pregnancy, the maternal immune response needs to adapt to accommodate the semiallogeneic fetus. Disturbances in maternal tolerance are implicated in infertility and pregnancy complications such as miscarriages (RM) and preeclampsia (PE). It is well-known that a subset of T lymphocytes, regulatory T cells (Tregs) exhibit potent suppressive activity, and have a crucial role in curtailing the destructive response of the immune system during pregnancy, and preventing autoimmune diseases. Interestingly, vitamin D deficiency is common in pregnant women, despite the widespread use of prenatal vitamins, and adverse pregnancy outcomes such as RM, PE, intrauterine growth restriction have been linked to hypovitaminosis D during pregnancy. Research has shown that autoimmune diseases have a significant prevalence within the female population, and women with autoimmune disorders are at higher risk for adverse pregnancy outcomes. Provocatively, dysregulation of T cells plays a crucial role in the pathogenesis of autoimmunity, and adverse pregnancy outcomes where these pathologies are also associated with vitamin D deficiency. This article reviews the immunomodulatory role of vitamin D in autoimmune diseases and pregnancy. In particular, we will describe the role of vitamin D from conception until delivery, including the health of the offspring. This review highlights an observational study where hypovitaminosis D was correlated with decreased fertility, increased disease activity, placental insufficiency, and preeclampsia in women with APS.

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“…Our observations are similar with those recently reported by Rezavand and co-workers, showing that a significantly higher frequency of VDR FokI F allele is observed in preeclamptic patients (83%) than in controls (74%) and is associated with a 1.72-fold increased risk of PE. In particular, the FokI FF genotype resulted to be associated with a significantly higher blood pressure when compared to fF and ff +fF genotypes [40].…”

Section: Plos Onementioning

confidence: 88%

Role of Vitamin-D Receptor (VDR) single nucleotide polymorphisms in gestational hypertension development: A case-control study

et al. 2020

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Background Recent literature data have highlighted the important role of hypovitaminosis D in pregnancy complications and prenatal/perinatal health. Vitamin D action takes place through vitamin D receptor (VDR) activation. Two single nucleotide polymorphisms of VDR gene, FokI and BsmI, have been reported to affect VDR molecular signaling and be associated with several disorders, including hypertension. Methods We carried out a case-control study aimed to assess vitamin D serum levels together with the distribution of VDR FokI and BsmI in a population of 116 pregnant women with gestational hypertension (GH) and 69 normotensive pregnant women (CTR). Results Hypovitaminosis D was largely prevalent both in GH (81%) and CTR (69%) pregnant women. Vitamin D insufficiency (10–30 ng/ml) had a similar frequency in both cohorts (GH 60% vs CTR 58%), while vitamin D deficiency (<10 ng/ml) was more frequent in GH cohort than in CTR one (21% vs 11%). Regression analysis showed that GH was significantly (p = 0.031) linked to vitamin D status. Vitamin D deficiency was associated with a threefold-increased risk of developing GH, while a normal vitamin D status was protective against this pregnancy disorder. The VDR FF/bB haplotype was the most frequent in GH cohort, and resulted to increase by two folds the risk for GH. Notably, hypovitaminosis D was found in 92% of FF/bB GH pregnant women, 27% of which had deficient vitamin D levels compared with 11% of their normotensive counterparts. Conclusions Despite being preliminary, these findings suggest that genotyping of pregnant women for VDR polymorphisms may be useful for a tailored vitamin D supplementation strategy.

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The effect of VDR gene polymorphisms and vitamin D level on blood pressure, risk of preeclampsia, gestational age, and body mass index

Cited by 42 publications

References 23 publications

Vitamin D level, lipid profile, and vitamin D receptor and transporter gene variants in sickle cell disease patients from Kurdistan of Iraq

Vitamin D level, lipid profile, and vitamin D receptor and transporter gene variants in sickle cell disease patients from Kurdistan of Iraq

Immunomodulatory Effects of Vitamin D in Pregnancy and Beyond

Role of Vitamin-D Receptor (VDR) single nucleotide polymorphisms in gestational hypertension development: A case-control study

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