The effect of vitamin E on platelet aggregation

Short-term, Moderate Dosage Vitamin E Supplementation May Have No Effect on Platelet Aggregation, Coagulation Profile, and Bleeding Time in Healthy Individuals

“…A similar response was noted to PGE1 inhibition, with a peak response at 75 IU/day [37]. Some of the earlier in vivo studies of ␣-tocopherol and platelet aggregation demonstrating no change in aggregation include Gomes et al in 1976 andHuijgens et al in 1981. The former examined a high-risk group of subjects with coronary artery disease, administering 1000 IU of synthetic Vitamin E/day for 8 days.…”

“…The former examined a high-risk group of subjects with coronary artery disease, administering 1000 IU of synthetic Vitamin E/day for 8 days. This short-term supplementation resulted in no change in platelet aggregation using platelet-rich plasma [38]. The latter group used high dose synthetic Vitamin E, 2000 IU/day, in six healthy subjects for 10 days.…”

Effect of Vitamin E on Platelet Aggregation in Diabetic Retinopathy

“…The defective platelet function was correct ed by treatment with vitamin E. Gomes et al [8] have not found significant changes in platelet aggregation when using a-tocopherol. They suggested that the beneficial effect of vitamin E in the prevention and treat ment of thromboembolic phenomena is not the result of the tocopherol effect on platelet aggregation.…”

Vitamin E and Platelet Aggregation

“…This would, in turn, lead to a decreased tendency of platelets to aggregate [8]. However, in humans, tocopherol acetate, given in a dose of 1,000 IU daily for 8 days, has no effect on platelet aggregation [3]. In vitro, toco pherol inhibits the release reaction in a do se-dependent manner.…”