The effect of zolpidem on sleep quality, stress status, and nondipping hypertension

Huang, Yuli; Mai, Weiyi; Cai, Xiaoyan; Hu, Yunzhao; Song, Yuanbin; Qiu, Ruofeng; Wu, Yanxian; Kuang, Jian

doi:10.1016/j.sleep.2011.07.016

Cited by 37 publications

(36 citation statements)

References 35 publications

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“…The pathophysiological mechanisms underlying these effects are at present unknown, but an indirect effect due to an alteration of sleep structure seems unlikely, as the increase in glucose response to OGTT was present even after zolpidem treatment that is known not to impair sleep architecture [6][7][8].…”

Section: Discussionmentioning

confidence: 99%

“…BZ reduce sleep latency, the number of awakenings, the wakefulness state and the length of stage 1, 3, and 4 while they increase that of stage 2 and modify the latency and length of rapid eyes movements (REM) sleep [4,5]. These alterations seem not to be caused by imidazopyridines, new molecules used as hypnotics able to bind GABA A receptor with a specific selectivity for the BZ 1/omega one subtype [6][7][8]. These molecules reduce sleep latency and extend total sleep time but have little effects on sleep structure [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

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Impact of short-term treatment with benzodiazepines and imidazopyridines on glucose metabolism in healthy subjects

Gramaglia

Gigliardi

Olivetti

et al. 2014

J Endocrinol Invest

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This is the author's final version of the contribution published as: Gramaglia E;Ramella Gigliardi V;Olivetti I;Tomelini M;Belcastro S;Calvi E;Dotta A;Ghigo E;Benso A;Broglio F. Impact of short-term treatment with benzodiazepines and imidazopyridines on glucose metabolism in healthy subjects.. JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION. 37 Conclusions: This study suggests that BZ and imidazopyridines have a rapid glucometabolic effect that is detectable as early as after 15 days treatment.3

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Impact of short-term treatment with benzodiazepines and imidazopyridines on glucose metabolism in healthy subjects

Gramaglia

Gigliardi

Olivetti

et al. 2014

J Endocrinol Invest

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“…Poor sleep quality has been shown to be associated closely with cardiovascular complications and nondipping hypertension [13,14,18]. Silva et al [19] found that nocturnal sleep quality played an important role in BP levels and suggested evaluation of sleep quality in nondipper hypertensive patients.…”

Section: Discussionmentioning

confidence: 99%

“…In recent studies, it has been reported that poor sleep quality is associated with nondipping hypertension through activation of the sympathetic nervous system, and it was concluded that poor sleep quality and stressful status were independent predictors of nondipping hypertension [13,14]. Although the relationship between sleep quality and a dipping-nondipping pattern has been investigated in hypertensive patients, to our knowledge, it has not been investigated in normotensive individuals previously.…”

Section: Introductionmentioning

confidence: 96%

Is impaired sleep quality responsible for a nondipping pattern even in normotensive individuals?

Ulu

Ulu²,

Ulaşlı³

et al. 2013

Blood Pressure Monitoring

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“…Benzodiazepines and related drugs increase non-CAP (Parrino et al 1997;Terzano et al 1995), and may be expected to increase stable breathing periods. Zolpidem increases blood pressure dipping (Huang et al 2012), and could do so through the induction of stable NREM periods. The proportion of stable breathing periods will impact the computed apnea-hypopnea index, as these periods do not contribute to the metric.…”

Section: Periods Of Stable Breathing During Nrem Sleepmentioning

confidence: 99%

Distinct polysomnographic and ECG-spectrographic phenotypes embedded within obstructive sleep apnea

Thomas

Shin

Bianchi

et al. 2017

Sleep Science Practice

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Background: The primary metric extracted from the polysomnogram in patients with sleep apnea is the apnea-hypopnea index (or respiratory disturbance index) and its derivatives. Other phenomena of possible importance such as periods of stable breathing, features suggestive of high respiratory control loop gain, and sleep fragmentation phenotypes are not commonly generated in clinical practice or research. A broader phenotype designation can provide insights into biological processes, and possibly clinical therapy outcome effects. Methods: The dataset used for this study was the archived baseline diagnostic polysomnograms from the Apnea Positive Pressure Long-term Efficacy Study (APPLES). The electrocardiogram (ECG)-derived cardiopulmonary coupling sleep spectrogram was computed from the polysomnogram. Sleep fragmentation phenotypes used thresholds of sleep efficiency (SE) ≤ 70%, non-rapid eye movement (NREM) sleep N1 ≥ 30%, wake after sleep onset (WASO) ≥ 60 min, and high frequency coupling (HFC) on the ECG-spectrogram ≤ 30%. Sleep consolidation phenotypes used thresholds of SE ≥ 90%, WASO ≤ 30 min, HFC ≥ 50% and N1 ≤ 10%. Multiple and logistic regression analysis explored cross-sectional associations with covariates and across phenotype categories. NREM vs. REM dominant apnea categories were identified when the NREM divided by REM respiratory disturbance index (RDI) was > 1. Results: The data was binned first into mild, moderate, severe and extreme categories based on the respiratory disturbance index of < 10, 10-30, 30-60, and greater than 60, per hour of sleep. Using these criteria, 70, 394, 320 and 188 for polysomnogram, and 54, 296, 209 and 112 subjects for ECG-spectrogram analysis groups. All phenotypes were seen at all severity levels. There was a higher correlation of NREM-RDI with the amount of ECG-spectrogram narrow band coupling, vs. REM-RDI, 0.41 vs 0.14, respectively. NREM dominance was associated with male gender and higher mixed/central apnea indices. Absence of the ECG-spectrogram sleep consolidated phenotype was associated with an increased odds of being on antihypertensive medications, OR 2.65 [CI: 1.64-4.26], p = < 0.001. Conclusions: Distinct phenotypes are readily seen at all severities of sleep apnea, and can be identified from conventional polysomnography. The ECG-spectrogram analysis provides further phenotypic differentiation.

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The effect of zolpidem on sleep quality, stress status, and nondipping hypertension

Cited by 37 publications

References 35 publications

Impact of short-term treatment with benzodiazepines and imidazopyridines on glucose metabolism in healthy subjects

Impact of short-term treatment with benzodiazepines and imidazopyridines on glucose metabolism in healthy subjects

Is impaired sleep quality responsible for a nondipping pattern even in normotensive individuals?

Distinct polysomnographic and ECG-spectrographic phenotypes embedded within obstructive sleep apnea

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