The effect on taste upon the introduction of heteroatoms in sulphamates

Sulfamic Acid and Its N- and O-Substituted Derivatives

“…The effect on sulfamate taste of introduction of heteroatoms in place of carbon(s) was examined using 70 heterosulfamates and their corresponding carbon analogs. On substitution no change in taste occurred in 33 cases, sweetness was lost in 29 cases, and in 8 cases sweetness was induced …”