The Effectiveness of a Preprocedural Mouthrinse Containing Cetylpyridinium Chloride in Reducing Bacteria in the Dental Office

Feres, Magda; Figueiredo, Luciene Cristina; Faveri, Marcelo; Stewart, Bernal; Vizio, William De

doi:10.14219/jada.archive.2010.0193

Cited by 87 publications

(130 citation statements)

References 18 publications

Supporting

Mentioning

103

Contrasting

Unclassified

Order By: Relevance

“…The ideal sample size to assure adequate power for this study was calculated based on the data of Feres et al 3 Considering a difference of at least 682 CFUs between groups CPC+Zn+F and Water and assuming a standard deviation of 435, it was defined that 15 subjects per group is adequate to provide a 95% power with an α of 0.05.…”

Section: Methodology Sample Size Calculationmentioning

confidence: 99%

“…Three plates were placed on a support board attached to the reflector, which had been previously designed 3 for this type of experimental design, one on the bracket tray, and another on the office bench ( Figure 1). The room was locked and after 30 minutes, the plates were closed and labeled properly and sent to the laboratory for incubation.…”

Section: Experimental Design Randomization Allocation Concealment Amentioning

confidence: 99%

“…9 Different procedures, materials and antimicrobial agents have been proposed to minimize microbial cross-contamination in the dental office, such as immunization of dental staff, decontamination of surfaces, sterilization of instruments, use of personal protective barriers and pre-procedural mouthwashes. 9,10,11,12 Chlorhexidine (CHX) is considered the gold standard substance in controlling oral biofilm growth in the oral cavity or microbial spread by oral aerosols 3,4,9,13,14,15 due to its broad antibacterial spectrum 14,16 and substantivity of 8 to 12 hours. 14 However, other antiseptics have also been used as pre-procedural mouthwashes, such as essential oils 17 and cetylpyridinium chloride (CPC).…”

Section: Introductionmentioning

confidence: 99%

“…14 However, other antiseptics have also been used as pre-procedural mouthwashes, such as essential oils 17 and cetylpyridinium chloride (CPC). 3,15 CPC has an important antimicrobial activity 18,19 and is considered a safe product for marketing. 20 The authors of this study have previously demonstrated the effectiveness of a pre-procedural mouthwash containing CPC in reducing viable bacteria in dental aerosol after a prophylaxis with an ultrasonic scaler.…”

Section: Introductionmentioning

confidence: 99%

“…This study introduced CPC as a good alternative to CHX, due to its effective antibacterial action, fewer adverse effects and lower cost. 3 In addition, a recent clinical study has indicated that a higher concentration of CPC -0.07%, is very effective in controlling plaque accumulation and gingivitis; 18 however, to date no studies have evaluated the effectiveness of CPC at this higher concentration as a pre-procedural mouthwash.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Effectiveness of a pre-procedural mouthwash in reducing bacteria in dental aerosols: randomized clinical trial

et al. 2017

Self Cite

View full text Add to dashboard Cite

The aim of this randomized, single blinded clinical trial was to evaluate the effect of a pre-procedural mouthwash containing cetylpyridinium chloride (CPC), zinc lactate (Zn) and sodium fluoride (F) in the reduction of viable bacteria in oral aerosol after a dental prophylaxis with ultrasonic scaler. Sixty systemically healthy volunteers receiving dental prophylaxis were randomly assigned to one of the following experimental groups (15 per group): (i) rinsing with 0.075% CPC, 0.28% Zn and 0.05% F (CPC+Zn+F), (ii) water or (iii) 0.12% chlorhexidine digluconate (CHX), and (iv) no rinsing. Viable bacteria were collected from different locations in the dental office on enriched TSA plates and anaerobically incubated for 72 hours. The colonies were counted and species were then identified by Checkerboard DNA-DNA Hybridization. The total number of colony-forming units (CFUs) detected in the aerosols from volunteers who rinsed with CPC+Zn+F or CHX was statistically significantly (p<0.05) lower than of those subjects who did not rinse or who rinsed with water. When all locations were considered together, the aerosols from the CPC+Zn+F and CHX groups showed, respectively, 70% and 77% fewer CFUs than those from the No Rinsing group and 61% and 70% than those from the Water group. The mean proportions of bacterial species from the orange complex were statistically significantly (p<0.05) lower in aerosols from the CPC+Zn+F and CHX groups compared with the others two groups. In conclusion, the mouthwash containing CPC+Zn+F, is effective in reducing viable bacteria in oral aerosol after a dental prophylaxis with ultrasonic scaler.

show abstract

Section: Methodology Sample Size Calculationmentioning

confidence: 99%

Section: Experimental Design Randomization Allocation Concealment Amentioning

confidence: 99%