The effectiveness of eugenol against cisplatin-induced ototoxicity

Sakat, Muhammed Sedat; Kılıç, Korhan; Akdemir, Fazile Nur Ekinci; Yıldırım, Serkan; Eser, Gizem; Kızıltunç, Ahmet

doi:10.1016/j.bjorl.2018.07.007

Cited by 29 publications

(28 citation statements)

References 20 publications

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“…Eugenol suppresses the production of superoxide anion by neutrophils via the inhibition of the Raf/MEK/ERK1/2/p47phox-phosphorylation pathway [62]. Moreover, it protects against ototoxicity and neurotoxicity induced by cisplatin and aluminium, respectively, via enhancing the activities of antioxidant enzymes and lowering the lipid peroxidation and 8-OHdG levels [63,64]. In vitro, the pretreatment of HCT116 cells with eugenol, 2 h prior to the mycotoxin citrinin exposure, significantly inhibited ROS generation, modulated the antioxidants enzymes activities, and reduced MDA production, protein-bound sulfhydryls level, and DNA fragmentation [65].…”

Section: Discussionmentioning

confidence: 99%

Ethanolic Extract of Moringa oleifera Leaves Influences NF-κB Signaling Pathway to Restore Kidney Tissue from Cobalt-Mediated Oxidative Injury and Inflammation in Rats

et al. 2020

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This study aimed to describe the protective efficacy of Moringa oleifera ethanolic extract (MOEE) against the impact of cobalt chloride (CoCl2) exposure on the rat’s kidney. Fifty male rats were assigned to five equal groups: a control group, a MOEE-administered group (400 mg/kg body weight (bw), daily via gastric tube), a CoCl2-intoxicated group (300 mg/L, daily in drinking water), a protective group, and a therapeutic co-administered group that received MOEE prior to or following and concurrently with CoCl2, respectively. The antioxidant status indices (superoxide dismutase (SOD), catalase (CAT), and reduced glutathione (GSH)), oxidative stress markers (hydrogen peroxide (H2O2), 8-hydroxy-2-deoxyguanosine (8-OHdG), and malondialdehyde (MDA)), and inflammatory response markers (nitric oxide (NO), tumor necrosis factor (TNF-α), myeloperoxidase (MPO), and C-reactive protein (CRP)) were evaluated. The expression profiles of pro-inflammatory cytokines (nuclear factor-kappa B (NF-kB) and interleukin-6 (IL-6)) were also measured by real-time quantitative polymerase chain reaction (qRT-PCR). The results showed that CoCl2 exposure was associated with significant elevations of oxidative stress and inflammatory indices with reductions in the endogenous tissue antioxidants’ concentrations. Moreover, CoCl2 enhanced the activity of the NF-κB inflammatory-signaling pathway that plays a role in the associated inflammation of the kidney. MOEE ameliorated CoCl2-induced renal oxidative damage and inflammatory injury with the suppression of the mRNA expression pattern of pro-inflammatory cytokine-encoding genes. MOEE is more effective when it is administered with CoCl2 exposure as a prophylactic regimen. In conclusion, MOEE administration exhibited protective effects in counteracting CoCl2-induced renal injury in rats.

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Section: Discussionmentioning

confidence: 99%

Ethanolic Extract of Moringa oleifera Leaves Influences NF-κB Signaling Pathway to Restore Kidney Tissue from Cobalt-Mediated Oxidative Injury and Inflammation in Rats

et al. 2020

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“…They were fed with standard laboratory food and water ad libitium . Eugenol and cisplatin doses were selected from doses used by Kilic et al (), Magalhaes et al (), Sakat et al (). In our study, 24 male albino Sprague Dawley albino rats were divided into four main groups ( n = 6): In the control group, no treatment was applied. Single dose of cisplatin (15 mg/kg b.wt) was administered intraperitoneally to cisplatin group. Eugenol (100 mg/kg b.wt./day) was given to eugenol group intraperitoneally daily for 5 days. Eugenol (100 mg/kg i.p.…”

Section: Methodsmentioning

confidence: 99%

“…Histopathological samples were stained with haematoxylin–eosin (HE) and assayed by light microscopy. (Leica DM 1000, Germany) The histopathological examination method used in this study was motivated in accordance with the method used in previous studies (Kilic et al, ; Sakat et al, ). Due to histopathological findings, the sections were evaluated as no (−), mild (+), moderate (++) and severe (+++).…”

Section: Methodsmentioning

confidence: 99%

“…Due to immunity positivity, no (−), mild (+), moderate (++) and severe (+++) parameters are used to evaluate the sections. The immunohistochemical evaluation method used in this study was motivated in accordance with the method used in earlier studies (Ekinci‐Akdemir et al, ; Kilic et al, ; Sakat et al, ).…”

Section: Methodsmentioning

confidence: 99%

“…Eugenol extensively takes role in natural food‐flavouring since it has been discovered in clove, basil, nutmeg and cinnamon. Earlier studies have indicated eugenol's antioxidant potential, which performed protection against oxidative tissue damage significantly in various experimental animal studies (Ito, Murakami, & Yoshino, ; Leaicardoso et al, ; Morsy & Fouad, ; Sakat et al, ).…”

Section: Introductionmentioning

confidence: 97%

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The antiapoptotic and antioxidant effects of eugenol against cisplatin‐induced testicular damage in the experimental model

et al. 2019

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Testicular dysfunction or damage is among the critical side effects of chemotherapeutic drugs like cisplatin. This study was mapped out to assess the possible therapeutic effect of eugenol on cisplatin‐induced testicular damage. In this experimental study, a single dose of cisplatin (15 mg/kg) was given intraperitoneally. After 72 hr of cisplatin injection, rats were sacrificed and testis tissues were removed. Tissues were examined by biochemical, histopathological and immunohistochemical methods. While tissue lipid peroxidation product and apoptotic marker levels increased, antioxidant enzyme activities of testis tissue were decreased in the cisplatin group. Additionally, histopathological damage was also determined in testis tissue. Contrary to all these results, the severity of damage in the tissue was reduced histopathologically owing to eugenol treatment. The lipid peroxidation decreased and antioxidant enzyme activities increased in the eugenol treatment group. It has been determined that eugenol has a therapeutic effect on oxidative stress and apoptosis against cisplatin‐induced testicular damage.

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Natural products against cisplatin‐induced male reproductive toxicity: A comprehensive review

Rahimi

Asadi

Rezghi

et al. 2021

J Biochem & Molecular Tox

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Cisplatin is widely used as one of the most effective anticancer agents in the treatment of some neoplasms. Reproductive toxicity is the most common outcome associated with cisplatin testicular damage. Alternative natural medicines for treating male testicular disorders and infertility have received extensive attention in research. Natural products, medicinal herbs, and their secondary metabolites have been shown as promising agents in the management of testicular damage induced by chemotherapy drugs. This study aimed to review the research related to natural substances that are promising in mitigation of the cisplatin‐induced toxicity in the reproductive system. PubMed and Scopus were searched for studies on various natural products for their potential protective property against reproductive toxicity induced by cisplatin from 2000 to 2020. Eligibility was checked based on selection criteria. Fifty‐nine articles were included in this review. Mainly in animal studies, several natural agents have positively affected cisplatin‐reproductive‐toxicity factors, including reactive oxygen species, inflammatory mediators, DNA damage, and activation of the mitochondrial apoptotic pathway. Most of the natural agents were investigated in short‐term duration and high doses of cisplatin exposure, considering their antioxidant activity against oxidative stress. Considering antioxidant properties, various natural products might be effective for the management of cisplatin reproductive toxicity. However, long‐term recovery of spermatogenesis and management of low‐dose‐cisplatin toxicity should be considered as well as the bioavailability of these agents before and after treatment with cisplatin without affecting its anticancer activity.

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The effectiveness of eugenol against cisplatin-induced ototoxicity

Abstract: The study findings represent the first indication in the literature that eugenol may protect against ototoxicity by raising levels of antioxidant enzymes and lowering those of oxidant parameters.

Cited by 29 publications

References 20 publications

Ethanolic Extract of Moringa oleifera Leaves Influences NF-κB Signaling Pathway to Restore Kidney Tissue from Cobalt-Mediated Oxidative Injury and Inflammation in Rats

Ethanolic Extract of Moringa oleifera Leaves Influences NF-κB Signaling Pathway to Restore Kidney Tissue from Cobalt-Mediated Oxidative Injury and Inflammation in Rats

The antiapoptotic and antioxidant effects of eugenol against cisplatin‐induced testicular damage in the experimental model

Natural products against cisplatin‐induced male reproductive toxicity: A comprehensive review

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