The effects of 5-HT receptor blockade on memory formation in the chick: Possible interactions between β-adrenergic, and serotonergic systems

Stephenson, R. M.; Andrew, R.J.

doi:10.1016/0091-3057(94)90207-0

Cited by 6 publications

(4 citation statements)

References 25 publications

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“…The relationship between 5-HT 1B receptor stimulation/ blockade and learning performance has remained unclear (see Introduction). This is probably due to the use of (Meneses, 2001;Meneses et al, 1997;Stephenson and Andrew, 1994). The facilitatory effect on PA retention seen after systemic administration of NAS-181 suggests a role for the 5-HT 1B receptor in aversive learning.…”

Section: Discussionmentioning

confidence: 97%

“…A spatial memory deficit was found following intrahippocampal administration of the 5-HT 1B receptor agonist CP-93,129 in the rat (Buhot et al, 1995). However, the nonspecific 5-HT 1B antagonist 21-009 given prior to training in the passive avoidance (PA) task induced amnesia in the domestic chick (Stephenson and Andrew, 1994). A study using 5-HT 1B receptor knockout mice reported enhanced spatial performance in the water maze (WM), but no effect in a contextual fear-conditioning paradigm (Malleret et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

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Analysis of the Role of the 5-HT1B Receptor in Spatial and Aversive Learning in the Rat

Ahlander-Lüttgen

Madjid

Schött

et al. 2003

Neuropsychopharmacol

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The present study examined the role of the 5-HT 1B receptor in learning and memory. The ability of the 5-HT 1B receptor agonist anpirtoline and the selective 5-HT 1B receptor antagonist NAS-181 to affect spatial learning in the water maze (WM) and aversive learning in the passive avoidance (PA) task were examined in the rat. Anpirtoline (0.1-1.0 mg/kg, s.c.) caused a dose-dependent impairment of learning and memory in both the WM and PA tasks. NAS-181 (1.0-10 mg/kg, s.c.) failed to alter performance of the WM task, but produced a dose-dependent (0.1-20 mg/kg) facilitation of PA retention. Furthermore, treatment with NAS-181 (10 mg/kg) fully blocked the impairment of the WM and PA performance caused by anpirtoline (1.0 mg/kg). In contrast, NAS-181 (3.0-10 mg/kg) did not attenuate the spatial learning deficit and the impairment of PA retention caused by scopolamine (0.1 mg/kg in WM task, 0.3 mg/kg in PA task, s.c.), a nonselective muscarinic antagonist. Moreover, a subthreshold dose of scopolamine (0.1 mg/kg) blocked the facilitation of PA retention induced by NAS-181 (1.0-10 mg/kg). In addition, the behavioral disturbances (eg thigmotaxic swimming and platform deflections) induced by anpirtoline and scopolamine were analyzed in the WM task and correlated with WM performance. These results indicate that: (1) 5-HT 1B receptor stimulation and blockade result in opposite effects in two types of cognitive tasks in the rat, and that (2) the 5-HT 1B antagonist NAS-181 can facilitate some aspects of cognitive function, most likely via an increase of cholinergic transmission. These results suggest that 5-HT 1B receptor antagonists may have a potential in the treatment of cognitive deficits resulting from loss of cholinergic transmission.

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Analysis of the Role of the 5-HT1B Receptor in Spatial and Aversive Learning in the Rat

Ahlander-Lüttgen

Madjid

Schött

et al. 2003

Neuropsychopharmacol

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“…The aspartic acid residue (D) in TM3 and two serine residues (S) in TM5 for dopamine binding are indicated in bold type. (Stephenson and Andrew, 1994;Cahill et al, 1994; and primers made from conserved amino acids in transmembrane domains (TM) 6 and 7 of a Drosophila octo- McGaugh et al, 1993).…”

Section: Introductionmentioning

confidence: 99%

“…injected at the time of learning during passive avoidance Nevertheless, the interaction sites with G s proteins for training (Stephenson and Andrew, 1994). Dopamine D1 second messenger signaling appear to be conserved, receptors play a selective role in the mnemonic process since DAMB is capable of activating the second mesduring oculomotor-delayed response tasks in primates senger cascade in mammalian cells.…”

Section: Introductionmentioning

confidence: 99%

DAMB, a Novel Dopamine Receptor Expressed Specifically in Drosophila Mushroom Bodies

Han

Millar

Grotewiel

et al. 1996

Neuron

262

285

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The modulatory neurotransmitters that trigger biochemical cascades underlying olfactory learning in Drosophila mushroom bodies have remained unknown. To identify molecules that may perform this role, putative biogenic amine receptors were cloned using the polymerase chain reaction (PCR) and single-strand conformation polymorphism analysis. One new receptor, DAMB, was identified as a dopamine D1 receptor by sequence analysis and pharmacological characterization. In situ hybridization and immunohistochemical analyses revealed highly enriched expression of DAMB in mushroom bodies, in a pattern coincident with the rutabaga-encoded adenylyl cyclase. The spatial coexpression of DAMB and the cyclase, along with DAMB's capacity to mediate dopamine-induced increases in cAMP make this receptor an attractive candidate for initiating biochemical cascades underlying learning.

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Drug effects on learning and memory1

Vogel¹,

Vogel²,

Schölkens³

et al. 2002

Drug Discovery and Evaluation

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The effects of 5-HT receptor blockade on memory formation in the chick: Possible interactions between β-adrenergic, and serotonergic systems

Cited by 6 publications

References 25 publications

Analysis of the Role of the 5-HT1B Receptor in Spatial and Aversive Learning in the Rat

Analysis of the Role of the 5-HT1B Receptor in Spatial and Aversive Learning in the Rat

DAMB, a Novel Dopamine Receptor Expressed Specifically in Drosophila Mushroom Bodies

Drug effects on learning and memory1

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