“…Caffeine elevates respiratory and metabolic rate (Lombardo, 1986), acts as a diuretic on kidneys (Bellet, Roman, DeCastro, Kim & Kershbaum, 1969), reduces liver and mesenteric blood flow (Onrot, Goldberg, Biaggioni, Hollister & Kincaid, 1985;Onrot, Shaheen, Biaggioni, Golbert & Feely, 1986), leads to colon anxiety (Cines & Rozin, 1982), reduces competence of the esophageal sphincter muscle (i.e., heartburn; Bunker & McWilliams, 1979), affects vagal, medullary and vasomotor centers (Syed, 1976). At high concentrations, caffeine collects in muscle tissue (Burg, 1975) and can interfere with neuromuscular transmission (VanHandle, 1983, pg.…”