The Effects of Crocin on 6-OHDA-Induced Oxidative/Nitrosative Damage and Motor Behaviour in Hemiparkinsonian Rats

Hosseini, Maryam Sadat; Rajaei, Ziba; Alaei, Hojjatallah; Tajadini, Mohamadhasan

doi:10.21315/mjms2016.23.6.4

Cited by 15 publications

(4 citation statements)

References 49 publications

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“…In the present study, a microinjection of 6-OHDA into the MFB caused oxidative damage to membrane lipids, as evidenced by decreased total thiol concentrations and increased TBARS levels in the striatum at the end of week six. In line with this, studies have demonstrated that 6-OHDA leads to a reduction in glutathione content and superoxide dismutase and catalase activity, and an increase in lipid peroxidation in the striatum 24,29 .…”

Section: Discussionmentioning

confidence: 61%

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Effects of carvacrol and physical exercise on motor and memory impairments associated with Parkinson’s disease

Hamzehloei

Rezvani

Rajaei

2019

Arq. Neuro-Psiquiatr.

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The present study was undertaken to investigate the effects of carvacrol and treadmill exercise on memory deficit, rotational behavior and oxidative stress biomarkers in a 6-OHDA-lesioned rat model of Parkinson’s disease. Wistar rats were treated with carvacrol at a dose of 25 mg/kg and/or ran on a treadmill for a week. Then, 6-OHDA was microinjected into the medial forebrain bundle and treatments continued for six more weeks. Aversive memory, rotational behavior and oxidative stress biomarkers were assessed at the end of week six. The 6-OHDA-lesioned group showed a significant increase in rotational behavior and a decrease in step-through latency in the passive avoidance test compared with the sham group. These behaviors were accompanied by increased lipid peroxidation levels and decreased total thiol concentration in the striatum and/or hippocampus of the hemiparkinsonian rats. Moreover, treatment with carvacrol and exercise reduced rotational behavior and improved aversive memory deficit, which was accompanied by decreased lipid peroxidation levels and increased total thiol concentration in the striatum and/or hippocampus. In conclusion, treatment with carvacrol and treadmill exercise ameliorated motor and memory deficits by modulating oxidative stress in the striatum and hippocampus of hemiparkinsonian rats. Therefore, the combination of carvacrol and treadmill exercise could be an effective therapeutic tool for treatment of neurobehavioral deficits in Parkinson’s disease patients.

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Section: Discussionmentioning

confidence: 61%

“…One minute after the injection, ipsi-and contralateral rotations were counted for 30 minutes in a dimly-lit, quiet room. The data were expressed as the net (contralateral minus ipsilateral turns) average rotations per 30 minutes 24 .…”

Section: Apomorphine-induced Rotation Testmentioning

confidence: 99%

Effects of carvacrol and physical exercise on motor and memory impairments associated with Parkinson’s disease

Hamzehloei

Rezvani

Rajaei

2019

Arq. Neuro-Psiquiatr.

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“…In 6‐OHDA‐treated mice, crocin (60 mg/kg; i.p. for 6 weeks) significantly reduced the nitrite levels and prevented the nitrosative damage in the striatum ( p < .05; Hosseini et al, 2016).…”

Section: Resultsmentioning

confidence: 96%

Protective effects of functional foods against Parkinson's disease: A narrative review on pharmacology, phytochemistry, and molecular mechanisms

Iranshahy

Javadi

Sahebkar

2022

Phytotherapy Research

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In Persian Medicine (PM), PD (brain‐based tremor) is a known CNS disorder with several therapeutic and preventive options. In their medical textbooks and pharmacopeias, Persian great scientists such as Rhazes (854–925 AD), Avicenna (980–1037 AD), and Jorjani (1042–1136 AD), have discussed pharmacological and nutritional strategies for the prevention, slowing progression, and treatment of PD. In the present study, we surveyed plant‐ and animal‐based foods recommended by PM for the prevention and treatment of CNS‐related tremors. In vivo and in‐vitro pharmacological evidence supporting the beneficial effects of PM‐recommended foods in prevention and alleviating PD, major active phytochemicals along with the relevant mechanisms of action were studied. Several PM plants possess potent antioxidant, antiinflammatory, and PD preventing properties. Garlic and allicin, cabbage and isothiocyanates, chickpea seed and its O‐methylated isoflavones biochanin A and formononetin, cinnamon, and cinnamaldehyde, saffron and its crocin, crocetin, and safranal, black cumin and its thymoquinone, black pepper and piperine, pistachio and genistein and daidzein, and resveratrol are among the most effective dietary itemsagainst PD. They act through attenuating neurotoxin‐induced memory loss and behavioral impairment, oxidative stress, and dopaminergic cell death. PM‐recommended foods can help alleviate PD progression and also discovering and developing new neuroprotective anti‐PD pharmaceuticals.

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“…Moreover, crocin (10 mg/kg) diminished TNF‐α and IL‐6 levels in the striatum of malathion‐treated rats, exhibiting PD‐like behavior (Mohammadzadeh et al, 2018). Nitrite levels in the striatum were drastically reduced after treatment with crocin at a dosage of 60 mg/kg in a unilateral 6‐OHDA‐induced model of PD (Hosseini et al, 2016).…”

Section: Crocin Inhibits Neuroinflammation In Parkinson's Diseasementioning

confidence: 99%

Therapeutic implications of crocin in Parkinson's disease: A review of preclinical research

et al. 2023

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Parkinson's disease is among the most common forms of neurodegenerative illness, with present treatment being primarily symptomatic and frequently coming with substantial adverse effects. Neuronal degeneration may arise due to a variety of pathological events, like inflammatory responses, neurotransmitter dysregulation, oxidative damage, mitochondrial malfunction, apoptosis, and genetic factors. The health issue and financial burden brought on by Parkinson's disease can worsen as the population ages. In the search for new and secure therapeutic agents for Parkinson's disease, several natural compounds have been shown to exert considerable neuroprotective benefits. Crocin, a naturally occurring carotenoid molecule, was found to have neuroprotective potential in the therapy of this disorder. Taking into account, the outcomes of various studies and the restorative actions of crocin, the present study emphasized the protective ability of crocin in this disease. Given the strong evidence supporting the neuroprotective ability of crocin, it is inferred that crocin inhibits inflammatory, apoptotic, and antioxidant processes through multiple mechanisms. Therefore, this compound is considered a safe and effective therapeutic choice for neurodegenerative illnesses like Parkinson's disease. However, more research on its efficacy as a treatment of Parkinson's disease is needed, specifically examining its mechanisms and the results obtained in clinical trials.

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The Effects of Crocin on 6-OHDA-Induced Oxidative/Nitrosative Damage and Motor Behaviour in Hemiparkinsonian Rats

Cited by 15 publications

References 49 publications

Effects of carvacrol and physical exercise on motor and memory impairments associated with Parkinson’s disease

Effects of carvacrol and physical exercise on motor and memory impairments associated with Parkinson’s disease

Protective effects of functional foods against Parkinson's disease: A narrative review on pharmacology, phytochemistry, and molecular mechanisms

Therapeutic implications of crocin in Parkinson's disease: A review of preclinical research

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