The effects of desynchronosis on the gut microbiota composition and physiological parameters of rats

Klimina, Ksenia M.; Батоцыренова, Е. Г.; Yunes, Roman А.; Gilyaeva, Elena H.; Полуэктова, Е. У.; Kostrova, T. A.; Kudryavtseva, Anna V.; Odorskaya, Maya V.; Kashuro, V. A.; Kasianov, Artem S.; Иванов, М. Б.; Даниленко, В. Н.

doi:10.1186/s12866-019-1535-2

Cited by 15 publications

(20 citation statements)

References 39 publications

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“…S3). An example is THRA , a thyroid hormone receptor that peaks at night in 17 tissues, the expression of which was found disrupted in the hypothalamic structures of rats in constant darkness or lighting ( 29 ). Similarly, SMC3 , a subunit of the cohesin complex, was highly expressed at night in 16 tissues.…”

Section: Resultsmentioning

confidence: 99%

Day-night and seasonal variation of human gene expression across tissues

Wucher

Sodaei

Amador

et al. 2021

Preprint

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Circadian and circannual cycles trigger physiological changes whose reflection on human transcriptomes remains largely uncharted. We used the time and season of death of 932 individuals from GTEx to jointly investigate transcriptomic changes associated with those cycles across multiple tissues. For most tissues, we found little overlap between genes changing expression during day-night and among seasons. Although all tissues remodeled their transcriptomes, brain and gonadal tissues exhibited the highest seasonality, whereas those in the thoracic cavity showed stronger day-night regulation. Core clock genes displayed marked day-night differences across multiple tissues, which were largely conserved in baboon and mouse, but adapted to their nocturnal or diurnal habits. Seasonal variation of expression affected multiple pathways and were enriched among genes associated with SARS-CoV-2 infection. Furthermore, they unveiled cytoarchitectural changes in brain subregions. Altogether, our results provide the first combined atlas of how transcriptomes from human tissues adapt to major cycling environmental conditions.

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Section: Resultsmentioning

confidence: 99%

Day-night and seasonal variation of human gene expression across tissues

Wucher

Sodaei

Amador

et al. 2021

Preprint

View full text Add to dashboard Cite

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“…Thus, we summarized recent studies focusing on the effects of circadian rhythm disruption on GM components in Table 4. 68,[87][88][89][90][91]…”

Section: Circadian Rhythm Disruption and Gm Alterationsmentioning

confidence: 99%

Sleep, circadian rhythm and gut microbiota: alterations in Alzheimer’s disease and their potential links in the pathogenesis

Shao

Yang

et al. 2021

Gut Microbes

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In recent years, emerging studies have observed gut microbiota (GM) alterations in Alzheimer's disease (AD), even in individuals with mild cognitive impairment (MCI). Further, impaired sleep and circadian patterns are common symptoms of AD, while sleep and circadian rhythm disruption (SCRD) is associated with greater β-amyloid (Aβ) burden and AD risk, sometimes years before the clinical onset of AD. Moreover, reports have demonstrated that GM and its metabolites exhibit diurnal rhythmicity and the role of SCRD in dampening the GM rhythmicity and eubiosis. This review will provide an evaluation of clinical and animal studies describing GM alterations in distinct conditions, including AD, sleep and circadian disruption. It aims to identify the overlapping and distinctive GM alterations in these conditions and their contributions to pathophysiology. Although most studies are observational and use different methodologies, data indicate partial commonalities in GM alterations and unanimity at functional level. Finally, we discuss the possible interactions between SCRD and GM in AD pathogenesis, as well as several methodological improvements that are necessary for future research.

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“…Compared to that within normal light-dark cycles conditions, the diversity of rat's gut microbiota was significantly different in darkness or constant lighting conditions. The ratios of bacteria families such as Lactobacillus, Bacteroides, and Parabacteroides were altered in darkness or constant lighting conditions ( 125 ). In addition to the alterations of gut microbiota taxon, the expression of genes related to protective immune function was reduced whereas the expression of genes associated with gut inflammation was enhanced after circadian disruption.…”

Section: Interplays Of Circadian Clock and Gut Microbiota During Naflmentioning

confidence: 99%

Advances in the Involvement of Gut Microbiota in Pathophysiology of NAFLD

et al. 2020

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Non-alcoholic fatty liver disease (NAFLD) is characterized by hepatic steatosis and progresses to non-steatohepatitis (NASH) when the liver displays overt inflammatory damage. Increasing evidence has implicated critical roles for dysbiosis and microbiota-host interactions in NAFLD pathophysiology. In particular, microbiota alter intestine absorption of nutrients and intestine permeability, whose dysregulation enhances the delivery of nutrients, endotoxin, and microbiota metabolites to the liver and exacerbates hepatic fat deposition and inflammation. While how altered composition of gut microbiota attributes to NAFLD remains to be elucidated, microbiota metabolites are shown to be involved in the regulation of hepatocyte fat metabolism and liver inflammatory responses. In addition, intestinal microbes and circadian coordinately adjust metabolic regulation in different stages of life. During aging, altered composition of gut microbiota, along with circadian clock dysregulation, appears to contribute to increased incidence and/or severity of NAFLD.

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The effects of desynchronosis on the gut microbiota composition and physiological parameters of rats

Cited by 15 publications

References 39 publications

Day-night and seasonal variation of human gene expression across tissues

Day-night and seasonal variation of human gene expression across tissues

Sleep, circadian rhythm and gut microbiota: alterations in Alzheimer’s disease and their potential links in the pathogenesis

Advances in the Involvement of Gut Microbiota in Pathophysiology of NAFLD

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