The effects of estrogen therapy and estrogen combined with different androgenic progestins on carbohydrate and lipid metabolism in overweight–obese younger postmenopausal women

Demır, Berfu; Öztürkoğlu, Esmen; Solaroglu, Ayse; Başkan, Bahar; Kandemir, Ömer; Karabulut, Erdem; Haberal, Alı

doi:10.1080/01443610802043066

Cited by 9 publications

(5 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Thus, the interruption of gonadal estrogen se- cretion, with the consequent androgen/estrogen imbalance, favors abdominal fat deposition with increased visceral fat [30,31]. In other studies, it has been reported that this deficiency is related to body weight gain and development of obesity in adult humans, mice and the OVX hamster [32][33][34].…”

Section: Discussionmentioning

confidence: 97%

Acute Administration of Tibolone Prevents Oxidative Stress in Ovariectomized Rats Fed High-Fat-and-Fructose Diet

Cruz

Pérez

Barrera

et al. 2018

Exp Clin Endocrinol Diabetes

View full text Add to dashboard Cite

In addition to oxidative stress due to the increase of free radicals, estrogen deficiency is associated with changes in enzymatic activity, glutathione redox ratio (GSH/GSSG), and the content of oxidative markers such as malondialdehyde. Tibolone, a synthetic steroid, has been used as an elective treatment for the relief of menopausal symptoms. However, the acute effects of hormonal therapy with tibolone on metabolic parameters and oxidative stress markers associated with the first stages of estrogen deficiency are still unknown. The study aimed to evaluate if the acute administration of tibolone reduces oxidative stress in ovariectomized rats fed high-fat-and-fructose diet. Rats were fed a standard diet or a diet consisting of 10% lard-supplemented chow and 20% high-fructose syrup in the drinking water plus tibolone or vehicle for seven days. Weight, cholesterol, triglycerides, and glucose levels, as well as antioxidant enzymes and oxidative stress markers were quantified in the serum of each experimental group. It was observed that seven days of diet and tibolone treatment in the ovariectomized group reduced weight, triglycerides, cholesterol, glucose levels and advanced glycation end products but did not change GSH/GSSG ratio nor the enzymatic activity of superoxide dismutase. Also, both glutathione peroxidase and glutathione reductase activity decreased, as well as malondialdehyde levels. These results suggest that the acute treatment with tibolone prevented the changes in the metabolic parameters analyzed as well as the increase in the levels of malondialdehyde and AGEs induced by ovariectomy and high-fat diet.

show abstract

Section: Discussionmentioning

confidence: 97%

Acute Administration of Tibolone Prevents Oxidative Stress in Ovariectomized Rats Fed High-Fat-and-Fructose Diet

Cruz

Pérez

Barrera

et al. 2018

Exp Clin Endocrinol Diabetes

View full text Add to dashboard Cite

show abstract

“…Deficiency or loss of estrogens in adult animals, e.g. in follicle-stimulating hormone receptor knock out mice [20], ovariectatomied (Ovx) mice and Syrian hamster [21-24], and aromatase knock out (ARKO) mice [16-18], is associated with bodyweight gain and the development of obesity. Furthermore, more interestingly, Gao et al [19] reported that estrogens regulated the body weight and energy metabolism in the brain in a way similar to that of the leptin, the hormone that regulates energy metabolism in the brain.…”

Section: Role Of Estrogens Estrogenic Chemicals and Ers In Obesitymentioning

confidence: 99%

“…The increase in adiposity is likely due to the decline in endogenous estrogens [20]. On the other hand, estrogen therapy has positive effects on carbohydrate and lipid metabolism in overweight-obese younger postmenopausal women [21, 22]. …”

Section: Role Of Estrogens Estrogenic Chemicals and Ers In Obesitymentioning

confidence: 99%

Regulation of energy metabolism pathways by estrogens and estrogenic chemicals and potential implications in obesity associated with increased exposure to endocrine disruptors

Chen

Brown

Russo

2009

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

164

View full text Add to dashboard Cite

The prevalence of obesity among children, adolescents and adults has been dramatically increasing worldwide during the last several decades. The obesity epidemic has been recognized as one of the major global health problems, because its health hazard is linked to a number of common diseases including breast and prostate cancers. Obesity is caused by combination of genetic and environmental factors. While genetic contribution to obesity has been known to be significant, the genetic factors remain relatively unchanged. Recent studies have highlighted the involvement of environmental “obesogens”, i.e. the xenobiotic chemicals that can disrupt the normal development and homeostatic control over adipogenesis and energy balance. Several lines of evidence suggest that increasing exposure to chemicals with endocrine-disrupting activities (endocrine disrupting chemicals, EDCs) contributes to the increased obesity. The cellular and molecular mechanisms underlying obesogen-associated obesity are just now being appreciated. In this paper, we comprehensively reviewed current knowledge about the role of estrogen receptors alpha and beta (ERα and ERβ) in regulation of energy metabolism pathways, including glucose transport, glycolysis, tricarboxylic acid (TCA) cycle, mitochondrial respiratory chain (MRC adenosine nucleotide translocator (ANT) and fatty acid β-oxidation and synthesis, by estrogens and then examined the disturbance of E2/ER-mediated energy metabolism pathways by environmental obesogens; and finally, we discussed the potential implications of disturbance of energy metabolism pathways by obesogens in obesity and pointed out several key aspects of this area that need to be further explored. A better understanding of the cellular and molecular mechanisms underlying obesogen-associated obesity will lead to new approaches for slow down and/or prevention of the increased trend of obesity associated with exposure to obesogens.

show abstract

“…Systemic loss of estrogen in postmenopausal women is typically associated with increased abdominal fat tissue. Studies have indicated that estradiol (E2) replacement can prevent menopause induced gains in adipose tissue mass [ 9 10 ]. In addition, ovariectomized (OVX) rodents rapidly become obese; however estrogen administration prevents the increase in body fat [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Estrogen deprivation and excess energy supply accelerate 7,12-dimethylbenz(a)anthracene-induced mammary tumor growth in C3H/HeN mice

et al. 2015

View full text Add to dashboard Cite

BACKGROUND/OBJECTIVESObesity is a risk factor of breast cancer in postmenopausal women. Estrogen deprivation has been suggested to cause alteration of lipid metabolism thereby creating a cellular microenvironment favoring tumor growth. The aim of this study is to investigate the effects of estrogen depletion in combination with excess energy supply on breast tumor development.MATERIALS/METHODSOvariectomized (OVX) or sham-operated C3H/HeN mice at 4 wks were provided with either a normal diet or a high-fat diet (HD) for 16 weeks. Breast tumors were induced by administration of 7,12-dimethylbenz(a)anthracene once a week for six consecutive weeks.RESULTSStudy results showed higher serum concentrations of free fatty acids and insulin in the OVX+HD group compared to other groups. The average tumor volume was significantly larger in OVX+HD animals than in other groups. Expressions of mammary tumor insulin receptor and mammalian target of rapamycin proteins as well as the ratio of pAKT/AKT were significantly increased, while pAMPK/AMPK was decreased in OVX+HD animals compared to the sham-operated groups. Higher relative expression of liver fatty acid synthase mRNA was observed in OVX+HD mice compared with other groups.CONCLUSIONSThese results suggest that excess energy supply affects the accelerated mammary tumor growth in estrogen deprived mice.

show abstract

The effects of estrogen therapy and estrogen combined with different androgenic progestins on carbohydrate and lipid metabolism in overweight–obese younger postmenopausal women

Cited by 9 publications

References 29 publications

Acute Administration of Tibolone Prevents Oxidative Stress in Ovariectomized Rats Fed High-Fat-and-Fructose Diet

Acute Administration of Tibolone Prevents Oxidative Stress in Ovariectomized Rats Fed High-Fat-and-Fructose Diet

Regulation of energy metabolism pathways by estrogens and estrogenic chemicals and potential implications in obesity associated with increased exposure to endocrine disruptors

Estrogen deprivation and excess energy supply accelerate 7,12-dimethylbenz(a)anthracene-induced mammary tumor growth in C3H/HeN mice

Contact Info

Product

Resources

About