For the first time in the Lower Volga region, comprehensive studies have been conducted to study the effectiveness of the use of compound feeds with different structures when adding cellobacterin and acidifiers to them in egg poultry farming. Their influence on the digestibility and digestibility of nutrients in diets, physiological and biochemical parameters of young and laying hens, egg productivity and egg quality, economic efficiency of production has been studied. As a result of research, the possibility of replacing animal feed with vegetable feed in compound feeds with the use of cellobacterin and acidifiers has been established, which, despite a slight increase in the consumption of compound feeds, leads to a reduction in the cost of rations per 1 laying hen to 11.48 rubles. Morphobiochemical blood parameters remain within the limits of physiological norms. The results of the studies conducted on laying hens showed that the safety of the livestock was 98%, egg production was 309.1 pieces in the control group and 310.7 pieces per laying hen in the experimental group, hematological indicators of laying hens in the control and experimental groups were almost at the same level. The consumption of compound feed for the period of experience in the control group of laying hens was 4414.41 kg in the amount of 67010.74 rubles, in the experimental group 4791.71 kg and 65886.01 rubles, respectively, that is, the difference in the cost of feed costs in favor of the experimental group was 1124.73 rubles. The production approbation confirmed the economic efficiency of the introduction of compound feeds into the poultry diet, in which animal feed is replaced with vegetable feed with the addition of cellobacterin and acidifiers.