The Effects of Halothane on Pregnant and Nonpregnant Human Myometrium

Naftalin, Nicholas J.; McKay, D.M.; Phear, W. P. C.; Goldberg, Alan H.

doi:10.1097/00006254-197707000-00002

Cited by 9 publications

(10 citation statements)

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“…Many inhalation anesthetics have been shown to have a direct depressant effect on uterine activity [1][2][3]. This report suggests that propofol shares this action in common with the inhalational agents.…”

mentioning

confidence: 70%

Effects of propofol on gravid human uterine muscle

et al. 1997

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mentioning

confidence: 70%

Effects of propofol on gravid human uterine muscle

et al. 1997

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“…This was contradicted by a study [23] reporting that, during 1.0-to 1.5-MAC anesthesia with isofl urane, uterine blood fl ow increased slightly or remained unchanged, until 2.0 MAC of isofl urane was administered. These changes were attributed to the relaxing effect of the anesthetic on the myometrium [24][25][26][27], leading to a reduction in uterine vascular resistance. In the present study, uterine blood fl ow remained essentially unchanged.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the effects of sevoflurane and isoflurane anesthesia on the maternal-fetal unit in sheep

et al. 2009

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“…It may be difficult to distinguish between sedative and analgesic effects, and steady state conditions with a constant end-tidal concentration were not achieved, so the effective concentration remains unknown. Furthermore, inhalation anaesthetics have a relaxant effect on uterine muscle [38,39], so that the analgesic effect could be caused by reduction in intensity of the contractions. Isoflurane has been used for sedation in intensive care [40], but the present study indicates that analgesics are necessary as a supplement to isoflurane.…”

Section: Discussionmentioning

confidence: 99%

The analgesic effect in humans of subanaesthetic isoflurane concentrations evaluated by experimentally induced pain

Petersen-Felix

Arendt‐Nielsen

Bak

et al. 1996

European Journal of Anaesthesiology

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SummaryThe analgesic effect of subanaesthetic concentrations of ether, trichloroethylene, methoxyflurane and halothane has been investigated previously using either clinical assessment or pain threshold measurements, but with conflicting results. The purpose of the present study was to evaluate the analgesic effect of isoflurane using experimental pain models. We studied 12 healthy volunteers at three randomly chosen subanaesthetic isoflurane concentrations: low (0.10-0.14 vol %), middle (0.16-0.20 vol %) and high (0.22-0.26 vol %). We used thermal pain detection and pain tolerance thresholds to argon laser stimulation, pressure pain detection and pain tolerance thresholds, immersion of the hand in ice water, and the nociceptive reflex to single and repeated (temporal summation) electrical stimulations, as experimental models to assess analgesia. There were no significant changes in the response to heat, cold or mechanical pressure at any of the subanaesthetic concentrations of isoflurane used. The nociceptive reflex thresholds to single stimulations, but not the thresholds for repeated stimulations, were significantly increased in all three isoflurane groups compared with baseline values. The difference between the different isoflurane concentrations was not statistically significant. In experimental pain models, subanaesthetic isoflurane concentrations have little or no analgesic potency. (Br. J. Anaesth. 1995; 75: 55-60)

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The Effects of Halothane on Pregnant and Nonpregnant Human Myometrium

Cited by 9 publications

References 0 publications

Effects of propofol on gravid human uterine muscle

Effects of propofol on gravid human uterine muscle

Comparison of the effects of sevoflurane and isoflurane anesthesia on the maternal-fetal unit in sheep

The analgesic effect in humans of subanaesthetic isoflurane concentrations evaluated by experimentally induced pain

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