The Effects of Hyperbaric Oxygen Treatment on the Healing of Tracheal Anastomosis Following Irradiation in Rats

Çelik, Burçin; Meydan, Ahmet Deniz; Kefeli, Mehmet; Gülen, E K; Okumus, Nilgun Ozbek

doi:10.1055/s-0030-1250273

Cited by 13 publications

(17 citation statements)

References 13 publications

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“…In large airway ischemia models in mice, HBOT has been shown to promote anastomotic healing, and is known to improve oxygen delivery and wound healing by inducing angiogenesis and neovascularization, recruiting endothelial stem cells, and reducing inflammation . Recent reports have also indicated that HBOT can be safely administered to patients with postoperative airway compromise.…”

Section: Discussionmentioning

confidence: 99%

“…We also found significant upregulation of hypoxia-inducible genes in donor airways, with expression of VEGFA, KDR, and HMOX1 being associated with prolonged respiratory failure, prolonged hospitalization, extensive airway necrosis, and CAS. 13 In large airway ischemia models in mice, HBOT has been shown to promote anastomotic healing, [30][31][32] and is known to improve oxygen delivery and wound healing by inducing angiogenesis and neovascularization, recruiting endothelial stem cells, and reducing inflammation. [33][34][35][36] Recent reports have also indicated that HBOT can be safely administered to patients with postoperative airway compromise.…”

Section: Discussionmentioning

confidence: 99%

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Safety of hyperbaric oxygen therapy for management of central airway stenosis after lung transplant

Mahmood

Kraft

Glisinski

et al. 2016

Clinical Transplantation

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Background Central airway stenosis (CAS) is common after lung transplantation and causes significant post-transplant morbidity. It is often preceded by extensive airway necrosis, related to airway ischemia. Hyperbaric oxygen therapy (HBOT) is useful for ischemic grafts and may reduce the development of CAS. Methods The purpose of this study was to determine whether HBOT could be safely administered to lung transplant patients with extensive necrotic airway plaques. Secondarily, we assessed any effects of HBOT on the incidence and severity of CAS. Patients with extensive necrotic airway plaques within 1–2 months after lung transplantation were treated with HBOT along with standard care. These patients were compared with a contemporaneous reference group with similar plaques who did not receive HBOT. Results Ten patients received HBOT for 18.5 (interquartile range, IQR 11–20) sessions, starting at 40.5 (IQR 34–54) days after transplantation. HBOT was well tolerated. Incidence of CAS was similar between HBOT-treated patients and reference patients (70% vs 87%, respectively; P=.34), but fewer stents were required in HBOT patients (10% vs 56%, respectively; P=.03). Conclusions This pilot study is the first to demonstrate HBOT safety in patients who develop necrotic airway plaques after lung transplantation. HBOT may reduce the need for airway stent placement in patients with CAS.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Safety of hyperbaric oxygen therapy for management of central airway stenosis after lung transplant

Mahmood

Kraft

Glisinski

et al. 2016

Clinical Transplantation

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“…In vitro, TGFβ expression and secretion by fibroblasts has been shown to be decreased in response to HBOT (12,58). A reduction of fibrosis by HBOT has been demonstrated in animal models of laminectomy, tracheal anastomosis and myocardial infarction (59)(60)(61), although in a tendon healing model, HBOT seemed to enhance fibrosis (62).…”

Section: Continued On Next Pagementioning

confidence: 99%

Gene Expression Analysis Reveals Inhibition of Radiation-Induced TGFβ-Signaling by Hyperbaric Oxygen Therapy in Mouse Salivary Glands

Spiegelberg

Swagemakers

IJcken

et al. 2014

Mol Med

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A side effect of radiation therapy in the head and neck region is injury to surrounding healthy tissues such as irreversible impaired function of the salivary glands. Hyperbaric oxygen therapy (HBOT) is clinically used to treat radiation-induced damage but its mechanism of action is largely unknown. In this study, we investigated the molecular pathways that are affected by HBOT in mouse salivary glands two weeks after radiation therapy by microarray analysis. Interestingly, HBOT led to significant attenuation of the radiation-induced expression of a set of genes and upstream regulators that are involved in processes such as fibrosis and tissue regeneration. Our data suggest that the TGFβ-pathway, which is involved in radiation-induced fibrosis and chronic loss of function after radiation therapy, is affected by HBOT. On the longer term, HBOT reduced the expression of the fibrosis-associated factor α-smooth muscle actin in irradiated salivary glands. This study highlights the potential of HBOT to inhibit the TGFβ-pathway in irradiated salivary glands and to restrain consequential radiation induced tissue injury.

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“…In the third step, the rabbits were decompressed at a rate of 0.15 ATA/min as described elsewhere. [9,10] …”

Section: Hyperbaric Oxygen Treatmentmentioning

confidence: 99%

“…[6][7][8][9][10] In practice, hyperbaric oxygen has also been successfully employed in the treatment of chest wall radionecrosis. [11,12] However, there is insufficient data in the literature regarding cartilage regeneration and growth after the resection of the deformed cartilages on the chest wall.…”

mentioning

confidence: 99%

Effects of hyperbaric oxygen treatment on cartilage regeneration: an experimental study

Çelik¹

2015

Turk Gogus Kalp Dama

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The Effects of Hyperbaric Oxygen Treatment on the Healing of Tracheal Anastomosis Following Irradiation in Rats

Abstract: This study suggests that hyperbaric oxygen treatment contributes to the healing of tracheal anastomosis following irradiation and may be a useful supportive treatment after tracheal resection and end-to-end anastomosis.

Cited by 13 publications

References 13 publications

Safety of hyperbaric oxygen therapy for management of central airway stenosis after lung transplant

Safety of hyperbaric oxygen therapy for management of central airway stenosis after lung transplant

Gene Expression Analysis Reveals Inhibition of Radiation-Induced TGFβ-Signaling by Hyperbaric Oxygen Therapy in Mouse Salivary Glands

Effects of hyperbaric oxygen treatment on cartilage regeneration: an experimental study

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