The effects of hyperbaric oxygen on normal and ischemic colon anastomoses

Hamzaoğlu, İsmail; Karahasanoğlu, Tayfun; Aydın, Salih; Şahin, Dursun Ali; Çarkman, Sinan; Sariyar, Muzaffer; Alemdaroğlu, K

doi:10.1016/s0002-9610(98)00234-7

Cited by 56 publications

(58 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It was able of improving mechanical resistance of anastomosis with or without presence of induced ischemia 17,39 .…”

Section: Discussionmentioning

confidence: 99%

“…As the surgical techniques and the suture materials, other factors interfere in anastomosis quality, as antibiotics 4,5 , antioxidants 6,7 , antineoplasics 8 , imunossupressors 9 , hormones 10 , trauma 11 , shock [12][13][14] , adherences 15,16 and ischemia 17,18 .…”

Section: Introductionmentioning

confidence: 99%

“…Its effects in improving normal colonic anastomosis or with ischemia have been studied 17 , however its action in normal colonic anastomosis under the presence of peritonitis is still controverse 28 .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Hyperbaric oxygen therapy and mechanical resistence of the colonics anastomosis in rats with peritonitis

et al. 2010

View full text Add to dashboard Cite

Purpose:To analyze the effects of hyperbaric oxygen therapy (HBO) on the mechanical resistance of anastomosis performed in rats' distal colon presenting peritonitis induced by ligature and cecal punction using the Total Energy Rupture biomechanical test (ETR). Methods: It was used 45 rats divided into three groups of 15 animals each. In Control Group (CG), it was performed anastomosis in distal colon without peritonitis. In Peritonitis Group (PG), it was performed anastomosis six hours after the induction of peritonitis by ligature and cecal punction. In Hyperbaric Chamber Group (HCG), it was performed six hours after the induction of peritonitis by ligature and cecal punction. The animals on CG and PG were kept at place air while the animals on HCG were placed on an experimental hyperbaric chamber in order to inhale oxygen at 100%, two absolute atmospheres, for 120 minutes, for four consecutive days. Euthanasia took place on the fifth day of the experiment. All the animals underwent to Total Energy Rupture Biomechanical Resistance test (ETR). Total Energy Rupture was defined as the necessary internal energy stored up to promote the colon rupture after an external traction force imposition. Results: The Peritonitis Group presents smaller average ETR than Control Group. There was no statistical difference between Peritonitis Group and Hyberbaric Chamber Group. Conclusion: Hyperbaric oxygen therapy did not alter the mechanical resistance of anastomosis performed in distal colon of rats under the presence of peritonitis induced by ligature and cecal puncture. Key words: Anastomosis, Surgical. Colon. Hyperbaric Oxygenation. Peritonitis. Rats. RESUMO Objetivo:Analisar o efeito da oxigenoterapia hiperbárica (HBO) sobre a resistência mecânica de anastomoses realizadas em cólon distal de ratos na presença de peritonite induzida por ligadura e punção cecal utilizando o teste biomecânico de Energia Total de Ruptura (ETR). Métodos: Foram utilizados 45 ratos distribuídos em três grupos de 15 animais. No Grupo Controle (GC), realizou-se anastomose no cólon distal sem peritonite. No Grupo Peritonite (GP), realizou-se anastomose seis horas após a indução da peritonite por ligadura e punção cecal. No Grupo Câmara Hiperbárica (GCH), realizou-se anastomose seis horas após a indução da peritonite por ligadura e punção cecal. Os animais dos GC e GP foram mantidos em ar ambiente. Os animais do GCH foram colocados em uma câmara hiperbárica experimental para inalarem oxigênio a 100%, a duas atmosferas absolutas, durante 120 minutos, por quatro dias consecutivos. A eutanásia ocorreu no quinto dia do experimento. Todos os animais foram submetidos ao Teste de Resistência Biomecânico Energia Total de Ruptura (ETR). A Energia Total de Ruptura foi definida como a energia interna acumulada necessária para promover o rompimento do cólon após a imposição de uma força externa de tração. Resultados: O Grupo Peritonite apresentou menor média de ETR que o Grupo Controle. Não houve diferença estatística entre o Grupo Peritonite e o Grupo C...

show abstract

“…It was able of improving mechanical resistance of anastomosis with or without presence of induced ischemia 17,39 .…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Hyperbaric oxygen therapy and mechanical resistence of the colonics anastomosis in rats with peritonitis

et al. 2010

View full text Add to dashboard Cite

show abstract

“…Among these, local tissue hypoxia is one of the most relevant variables in healing. This is because oxygen molecules are indispensable elements in collagen synthesis and the production of fibroblasts 9 . Diminished blood flow in the surgical incision leads to dehiscence.…”

Section: Discussionmentioning

confidence: 99%

“…In the various possible clinical scenarios, one of the methods to increase oxygen levels is hyperbaric oxygen therapy (HBO) 8 . More specifically, a MEDLINE review of the available literature concerning the use of HBO in anastomosis in the alimentary tract retrieved two papers, both addressing colic anastomosis experimentally induced in rats [9][10] . However, no paper on the use of HBO to treat esophageal anastomosis was found.…”

Section: Introductionmentioning

confidence: 99%

Effect of hyperbaric oxygen therapy on esophagojejunal anastomosis healing in rats

Lionço¹,

Lionço²,

Filippi³

et al. 2008

Acta Cir. Bras.

View full text Add to dashboard Cite

Purpose: To evaluate hyperbaric oxygen therapy (HBO) after esophagojejunal anastomosis in a rat experimental model and the effect of HBO on the healing of esophagojejunal anastomosis in gastrectomized rats. Methods: Forty adult male Wistar rats, weighing 322 g to 506 g, were divided into two random groups. In group A (control group), 20 rats were subjected to total gastrectomy. In group B, 20 rats were similarly gastrectomized, but also received postoperative HBO treatment for 90 minutes/day for seven days. All rats were sacrificed on the eighth postoperative day and evaluated according to the following study variables: a) presence of anastomotic fistula; b) evaluation of esophagojejunal anastomosis healing by measuring the breaking strength at the suture line as per Hendriks & Mastboom; and c) determining the collagen concentration in the anastomosis, as per Kovács criteria. For the comparative statistical analysis between groups, Student's "t" test was used. A value of p<0.05 was considered significant. Results: There was a 20% mortality rate. There were five deaths in group A and three in group B (p=N.S.). There was only one anastomotic fistula in each group, and neither caused any morbidity or death. Breaking strength measured at the suture line (p=0.528) and collagen concentration determined at the esophagojejunal anastomosis (p=0.89) were not significantly different between Groups A and B. Conclusion: Hyperbaric oxygen therapy did not affect the healing process of esophagojejunal anastomosis. Key words: Anastomosis, Surgical. Collagen. Tensile Strength. Oxygen Inhalation Therapy. Rats. RESUMO Objetivo:Avaliar o efeito da oxigenoterapia hiperbárica na cicatrização da anastomose esôfagojejunal em ratos gastrectomizados. Métodos: 40 ratos Wistar, adultos machos, pesando entre 322g e 506g, foram divididos aleatoriamente em dois grupos. No grupo A (grupo controle) 20 ratos foram submetidos à gastrectomia total. No grupo B, 20 ratos foram gastrectomizados e receberam tratamento pós-operatório com oxigênio hiperbárico, 90 minutos/dia durante sete dias. Todos os ratos foram sacrificados no oitavo dia pós-operatório e avaliados de acordo com as seguintes variáveis: a) presença de fístula anastomótica; b) avaliação da cicatrização da anastomose esôfagojejunal pela medida da força de ruptura à tração na linha da sutura conforme Hendriks & Mastboom; c) determinação da concentração de colágeno na anastomose pelos critérios de Kovács. Para análise estatística comparativa entre os grupos foi utilizado o teste "t" de Student, considerando-se como significativo o valor de p=0.05. Resultados: A mortalidade foi de 20%. Morreram cinco ratos do grupo A e tres do grupo B (p= N.S.). Ocorreu uma fístula anastomótica em cada grupo não relacionadas a óbito. A medida da força de ruptura à tração na linha da sutura (p= 0.528) e a determinação da concentração de colágeno na anastomose esôfagojejunal (p= 0.89) não mostrou diferença estatisticamente significativa entre os grupos A e B. Conclusão: A oxigenoterapia hiperbárica não...

show abstract

Perioperative Hyperoxygenation and Wound Site Infection Following Surgery for Acute Appendicitis

Bickel

Gurevits²,

Vamos³

et al. 2011

Arch Surg

111

105

View full text Add to dashboard Cite

show abstract

The effects of hyperbaric oxygen on normal and ischemic colon anastomoses

Cited by 56 publications

References 26 publications

Hyperbaric oxygen therapy and mechanical resistence of the colonics anastomosis in rats with peritonitis

Hyperbaric oxygen therapy and mechanical resistence of the colonics anastomosis in rats with peritonitis

Effect of hyperbaric oxygen therapy on esophagojejunal anastomosis healing in rats

Perioperative Hyperoxygenation and Wound Site Infection Following Surgery for Acute Appendicitis

Contact Info

Product

Resources

About