The effects of increased serotonergic activity on human sensory gating and its neural generators

Jensen, Kristian; Oranje, Bob; Wienberg, Malene; Glenthøj, Birte

doi:10.1007/s00213-007-1001-y

Cited by 33 publications

(24 citation statements)

References 54 publications

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“…Thus, frontal medial gyrus may play a role in automatically alerting inactive co-twins more than the active co-twins of deviant information ascending from the body. Sensory gating using different electrical stimulation paradigm has been applicably studied in psychiatry where source modeling has implicated frontal medial gyrus as an important player in gating (Bak et al 2011;Jensen et al 2008). Thus it may be that amplitude differences we have observed are explained by differences in sensory gating emerging from different levels of physical activity.…”

Section: Discussionmentioning

confidence: 86%

Somatosensory Brain Function and Gray Matter Regional Volumes Differ According to Exercise History: Evidence from Monozygotic Twins

et al. 2016

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Associations between long-term physical activity and cortical function and brain structure are poorly known. Our aim was to assess whether brain functional and/or structural modulation associated with long-term physical activity is detectable using a discordant monozygotic male twin pair design. Nine monozygotic male twin pairs were carefully selected for an intrapair difference in their leisure-time physical activity of at least three years duration (mean age 34 ± 1 years). We registered somatosensory mismatch response (SMMR) in EEG to electrical stimulation of fingers and whole brain MR images. We obtained exercise history and measured physical fitness and body composition. Equivalent electrical dipole sources of SMMR as well as gray matter (GM) voxel counts in regions of interest indicated by source analysis were evaluated. SMMR dipolar source strengths differed between active and inactive twins within twin pairs in postcentral gyrus, medial frontal gyrus and superior temporal gyrus and in anterior cingulate (AC) GM voxel counts differed similarly. Compared to active twins, their inactive twin brothers showed greater dipole strengths in short periods of the deviant-elicited SMMR and larger AC GM voxel counts. Stronger activation in early unattended cortical processing of the deviant sensory signals in inactive co-twins may imply less effective gating of somatosensory information in inactive twins compared to their active brothers. Present findings indicate that already in 30's long-term physical activity pattern is linked with specific brain indices, both in functional and structural domains.

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Section: Discussionmentioning

confidence: 86%

Somatosensory Brain Function and Gray Matter Regional Volumes Differ According to Exercise History: Evidence from Monozygotic Twins

et al. 2016

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“… 21 , 22 , 23 , 157 , 159 These and other studies have shown, however, that additional brain regions are also significant sources of P50 gating in the human brain. Gating generators may include the thalamus, 23 , 158 , 160 superior temporal gyrus/auditory cortex, 161 , 162 , 163 , 164 , 165 , 166 medial frontal cortex, 22 , 162 , 163 , 167 , 168 dorsolateral prefrontal cortex, 21 , 158 , 159 , 169 ventrolateral prefrontal cortex 160 and insula. 22 , 160 , 161 Animal studies have found additional gating generators in the medial septum, 170 thalamus, 64 striatum, 171 amygdala 172 and medial prefrontal cortex.…”

Section: Methodological Effects and Considerationsmentioning

confidence: 99%

Translational utility of rodent hippocampal auditory gating in schizophrenia research: a review and evaluation

et al. 2015

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Impaired gating of the auditory evoked P50 potential is one of the most pharmacologically well-characterized features of schizophrenia. This deficit is most commonly modeled in rodents by implanted electrode recordings from the hippocampus of the rodent analog of the P50, the P20–N40. The validity and effectiveness of this tool, however, has not been systematically reviewed. Here, we summarize findings from studies that have examined the effects of pharmacologic modulation on gating of the rodent hippocampal P20–N40 and the human P50. We show that drug effects on the P20–N40 are highly predictive of human effects across similar dose ranges. Furthermore, mental status (for example, anesthetized vs alert) does not appear to diminish the predictive capacity of these recordings. We then discuss hypothesized neuropharmacologic mechanisms that may underlie gating effects for each drug studied. Overall, this review supports continued use of hippocampal P20–N40 gating as a translational tool for schizophrenia research.

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“…All subjects were examined with the Copenhagen Psychophysiology Test Battery (CPTB) Jensen et al, 2008;Wienberg et al, 2010). The CPTB includes PPI, P50 suppression, mismatch negativity (MMN), and selective attention paradigms.…”

Section: Psychophysiologymentioning

confidence: 99%

Effects of Dopamine D2/D3 Blockade on Human Sensory and Sensorimotor Gating in Initially Antipsychotic-Naive, First-Episode Schizophrenia Patients

Düring

Glenthøj

Andersen

et al. 2014

Neuropsychopharmacol

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It has been suggested that psychophysiological measures of sensory and sensorimotor gating, P50 gating and prepulse inhibition of the startle reflex (PPI), underlie core features of schizophrenia and are linked to dopaminergic pathways in the striatum and prefrontal cortex. In the present study, the effects of a potent D2/D3 receptor antagonist, amisulpride, were investigated on PPI and P50 gating in a large sample of antipsychotic-naive, first-episode patients with schizophrenia. A total of 52 initially antipsychotic-naive, first-episode schizophrenia patients were assessed for their P50 gating, PPI, and habituation/sensitization abilities at baseline and after 2 and 6 weeks of treatment with flexible doses of amisulpride. In addition, 47 matched healthy controls were assessed at baseline and after 6 weeks. At baseline, the patients showed significantly reduced PPI, yet normal levels of P50 gating, habituation, and sensitization. Treatment with amisulpride showed no effects on these measures, either at 2 or 6 weeks of follow-up. This is the first study investigating the effects of monotherapy with a relatively selective dopamine D2/D3 receptor antagonist (amisulpride) on sensory and sensorimotor gating deficits in a longitudinal study of a large group of initially antipsychotic-naive, first-episode patients with schizophrenia. Our finding that amisulpride effectively reduced symptom severity in our patients without reducing their PPI deficits indicates that increased activity of dopamine D2 receptors may be involved in symptomatology of patients with schizophrenia, but not in their sensorimotor gating deficits.

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The effects of increased serotonergic activity on human sensory gating and its neural generators

Cited by 33 publications

References 54 publications

Somatosensory Brain Function and Gray Matter Regional Volumes Differ According to Exercise History: Evidence from Monozygotic Twins

Somatosensory Brain Function and Gray Matter Regional Volumes Differ According to Exercise History: Evidence from Monozygotic Twins

Translational utility of rodent hippocampal auditory gating in schizophrenia research: a review and evaluation

Effects of Dopamine D2/D3 Blockade on Human Sensory and Sensorimotor Gating in Initially Antipsychotic-Naive, First-Episode Schizophrenia Patients

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