The effects of long-term cadmium exposure in turkeys: Accumulation and zinc prevention

Naď, P.; Skalická, M.; Korénekova, Beáta

doi:10.1080/10934529.2012.672074

Cited by 6 publications

(4 citation statements)

References 37 publications

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“…SeMet can be available for selenoprotein synthesis, be released from tissues, and be efficient in maintaining the GPX level ( 53 , 54 ). Newairy et al ( 58 ) also pointed out that the protective potential of Se may be associated with the recovery of GPX and SOD activities. We also found that Se improved SOD activity in the serum, GPX activity in the liver and GPX activity, and GSH concentration in the ovary.…”

Section: Discussionmentioning

confidence: 99%

Protective effects of selenized yeast on the combination of cadmium-, lead-, mercury-, and chromium-induced toxicity in laying hens

Song²,

Li³

et al. 2022

Front. Vet. Sci.

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The objective of this study was to investigate the toxic effects of a combination of cadmium (Cd), lead (Pb), mercury (Hg), and chromium (Cr) on laying performance, egg quality, serum biochemical parameters, and oxidative stress of laying hens, as well as the alleviating action of dietary supplementation of selenized yeast. A total of 160 Lohmann pink-shell laying hens (63-week-old) were randomly divided into four treatments with 10 replicates of four hens each. The treatments were the corn–soybean meal basal diet (control; CON), the CON diet supplemented with 0.4 mg selenium (Se)/kg from selenized yeast (Se); combined heavy metals group: the basal diet supplemented with 5 mg Cd/kg, 50 mg Pb/kg, 3 mg Hg/kg, and 5 mg Cr/kg (HEM), and the HEM diet supplemented with 0.4 mg Se/kg from selenized yeast (HEM+Se). The experimental period lasted for 12 weeks. The HEM diet decreased hen-day egg production, feed conversion ratio (FCR), and egg white quality (P < 0.05), but increased (P < 0.05) glutamic oxalacetic transaminase (AST) activity in the serum. HEM induced higher malondialdehyde (MDA) and reactive oxygen species (ROS) in the serum, liver, and ovary and significantly decreased (P < 0.05) the activity of total superoxide dismutase (SOD) and tended to decrease glutathione S-transferase (GST) (P = 0.09) in the serum. Meanwhile, HEM significantly decreased (P < 0.05) activity of SOD, GST, glutathione peroxidase (GPX), and glutathione (GSH) in the liver, and the activity of GPX and GSH in the ovary. Se addition of 0.4 mg/kg significantly (P < 0.05) improved hen-day egg production and FCR and decreased AST concentration and increased some enzyme activity in the serum, liver, and ovary. In conclusion, dietary HEM exposure depressed laying performance, and egg white quality was likely due to an impaired antioxidant capacity, disrupted hepatic function, and elevated HEM accumulation in the egg yolk and egg white of laying hens. Se addition of 0.4 mg/kg ameliorated toxic effects of HEM on laying performance, oxidative stress, and hepatic function.

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Section: Discussionmentioning

confidence: 99%

Protective effects of selenized yeast on the combination of cadmium-, lead-, mercury-, and chromium-induced toxicity in laying hens

Song²,

Li³

et al. 2022

Front. Vet. Sci.

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“…This theory was supported by Teshfam et al (2006), who indicated that administrations might affect the absorption of Cd into the body. Nad et al (2012) reported high Cd absorption affinity by somatic cells of kidney and liver of turkeys, while Li et al (2018) obtained low Cd absorption affinity of the laying hen ovary.…”

Section: Toxic Levels Of Cadmiummentioning

confidence: 99%

“…The selenium function to protect the renal and hepatic tissues against the toxicity of Cd is a result of lipid peroxidation reduction and increases the activities of antioxidant enzymes in these tissues (Newairy et al 2007). Selenium supplementation increased the essential minerals (Cr, Mn, Zn, and Se) and decreased toxic mineral (Cd, Li, and Pb) contents in kidney tissues of chickens, which were induced by Cd, suggesting that Se may decrease the negative effects of Cd and improve the trace mineral homeostasis in tissues of chickens (Zhang et al 2017a;Bao et al 2018).…”

Section: Reviewmentioning

confidence: 99%

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2022

Czech J. Anim. Sci.

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Cadmium (Cd) is a toxic heavy metal, discharged into environments naturally or anthropogenically, where industrial and agricultural revolutions have led to serious Cd pollution into the environment. Poultry feed may be contaminated by Cd due to its presence in concentrates and supplements, and also in the machinery and equipment used in the feed production and processing. After absorption in the digestive system, Cd largely accumulates in kidneys, liver, bones and other organs and causes irreversible damage to these organs. Higher doses of Cd in poultry diet reduced feed intake, body weight, bone mineral density, egg production and eggshell quality. Selenium (Se) is an essential micronutrient and important component of a variety of antioxidant enzymes, with the ability to antagonize metal toxicity including Cd. Hence, in the current review, we try to summarize recent information about the toxicological effects of Cd and provide updated information about the role of Se as an effective strategy in reducing Cd toxicity in poultry.

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“…In addition, Cd uptake toxicity can vary according to cell type in the kidneys and liver (Li et al, 2018;Olgun et al, 2020). Nad et al (2012) evaluated Cd absorption in turkeys and observed an intense accumulation of Cd in bones, muscles, liver, and kidneys. Similar results have been reported by other studies (Ali et al, 2016;Jin et al, 2018;Kar et al, 2018;Vasiljeva et al, 2018), suggesting that liver and kidneys are more sensitive to Cd accumulation.…”

Section: Introductionmentioning

confidence: 99%

Golden mussel shell (<i>Limnoperna fortunei</i>) flour contaminated with cadmium as a calcium source for broiler chickens

Wachholz,

Andrade,

Souza

et al. 2024

SA J. An. Sci.

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The objective of this study was to evaluate the effects of golden mussel flour (GMSF) contaminated with increasing rates of cadmium (Cd) as a replacement for limestone as a Ca source, in broiler chicken feed from 14 to 42 days of age. A total of 60 animals were assigned to four treatments (inclusion rates of Cd: 6.94, 14.55, 22.40, and 30.00 mg Cd kg-¹) with five replications in a completely randomized design. At 42 d, blood samples were collected to evaluate serum concentrations of aspartate amino transferase (AST), alanine amino transferase (ALT), gamma glutamyl transferase (GGT), total bilirubin, Ca, P, and Cd. After slaughter, tissues were collected to evaluate Cd concentration in bone parameters. Growth performance of broiler chickens and Cd content in the breast meat were not affected by the inclusion rates of Cd in the GMSF. However, there was an effect of Cd in GMSF on the concentration of Cd in the skin, liver, bones, feathers, and serum; ALT; and total bilirubin. Bone flexibility had a quadratic response to increasing inclusion rates of GMSF; serum Ca concentration increased linearly and there was no effect on serum P concentration. Concentrations of Cd in GMSF above 20 mg kg-¹ caused high Cd contamination in broiler tissues. Therefore, it was concluded that Cd concentrations above 6.94 mg kg-¹ in broiler diets caused high Cd concentrations in meat and organs that are above those permitted for human consumption

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The effects of long-term cadmium exposure in turkeys: Accumulation and zinc prevention

Cited by 6 publications

References 37 publications

Protective effects of selenized yeast on the combination of cadmium-, lead-, mercury-, and chromium-induced toxicity in laying hens

Protective effects of selenized yeast on the combination of cadmium-, lead-, mercury-, and chromium-induced toxicity in laying hens

Untitled

Golden mussel shell (<i>Limnoperna fortunei</i>) flour contaminated with cadmium as a calcium source for broiler chickens

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