The Effects of Nutraceuticals and Herbal Medicine on Candida albicans in Oral Candidiasis: A Comprehensive Review

Gharibpour, Fateme; Shirban, Farinaz; Bagherniya, Mohammad; Nosouhian, Mohsen; Sathyapalan, Thozhukat; Sahebkar, Amirhossein

doi:10.1007/978-3-030-64872-5_16

Cited by 13 publications

(9 citation statements)

References 87 publications

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“…At a low dose, BBR treatment suppressed DR by inhibiting AGE/RAGE signalling in the retina, whereas at higher doses, BBR may directly suppress blood glucose levels, which may, subsequently, suppress AGE formation, improve the overall diabetic condition, and thus, relieve DR. Considering the safety of BBR, as determined by extensive clinical studies, 9 our results shed light on its use as a hypoglycemic alkaloid and an effective AGE inhibitor for the management of DR (Figure S5 ).…”

Section: Figurementioning

confidence: 83%

Berberine suppresses advanced glycation end products‐associated diabetic retinopathy in hyperglycemic mice

Wang

Zhang

et al. 2021

Clinical & Translational Med

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Section: Figurementioning

confidence: 83%

Berberine suppresses advanced glycation end products‐associated diabetic retinopathy in hyperglycemic mice

Wang

Zhang

et al. 2021

Clinical & Translational Med

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“…Herbs and naturally imitative bioactive compounds could be a new source of antimycotic therapy. Several review studies suggest that herbal medicines and natural bioactive compounds have antifungal effects [ 16 ]. Nutraceuticals such as curcumin ( Curcuma longa , polyphenol) and piperine ( Piper nigrum and Piper longum an alkaloid) are useful in the treatment of C. albicans in candidiasis and could be a safe, accessible, and inexpensive management option to prevent and treat disease [ 16 , 17 ].…”

Section: Discussionmentioning

confidence: 99%

Antibiofilm Activity of Curcumin and Piperine and Their Synergistic Effects with Antifungals against Candida albicans Clinical Isolates

Tsopmene,

Tokam Kuaté,

Kayoka-Kabongo

et al. 2024

Scientifica

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Background. Candidiasis is the common name for diseases caused by yeast of the genus Candida. Candida albicans is one of the most implicated species in superficial and invasive candidiasis. Antifungals, polyenes, and azoles have been used to treat candidiasis. However, due to the development of antifungal resistance, research of natural substances with potential antifungal effects at low concentrations or combined is also a possibility. Methods. The broth microdilution method was used to evaluate the antifungal activity. The biofilm formation was assessed using the microtiter plate method. The antibiofilm activities were assessed using micro plaque tetrazolium salt assay (MTT). The combination effect of antifungal with natural substances was made using the checkerboard method. Results. Among our isolates, clotrimazole was the most resistant, but amphotericin B was the most effective antifungal. The biofilm was formed by all isolates of C. albicans. Curcumin and piperine displayed antibiofilm activity with minimum biofilm inhibitory concentration (MBIC) and minimum eradicating concentration (MBEC) ranging from 64 to 1024 μg/mL and 256 to 2048 μg/mL. In combination, piperine presented double synergistic effects compared to curcumin with all antifungals tested. Curcumin shows more synergistic effect when combined with polyenes than with azoles. However, piperine shows a more synergistic effect when combined with azoles compared to polyenes. Conclusion. C. albicans was susceptible to curcumin and piperine both on planktonic cells and biofilm. The combination of curcumin and piperine with antifungals has shown synergistic effects against multiresistant clinical isolates of Candida albicans representing an alternative drug research for the treatment of clinical candidiasis.

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“…Candidiasis is an opportunistic yeast infection, and studies suggest that about 40%‐60% of the overall population carry oral Candida species, 1 among which Candida albicans is the most prevalent 2 . Although fungus may comprise part of the human microbiota, certain local and systemic factors may promote their growth and lead to candidiasis 3 …”

Section: Introductionmentioning

confidence: 99%

“…Candidiasis is an opportunistic yeast infection, and studies suggest that about 40%-60% of the overall population carry oral Candida species, 1 among which Candida albicans is the most prevalent. 2 Although fungus may comprise part of the human microbiota, certain local and systemic factors may promote their growth and lead to candidiasis. 3 There are many risk factors that make haematological patients susceptible to candidiasis, such as a prolonged hospital stay, treatment with broad-spectrum antibiotics, chemotherapy, radiotherapy, neoplastic diseases, immunosuppressive drugs for organ transplants, intubation, and catheter use.…”

Section: Introductionmentioning

confidence: 99%

Oral candidiasis in patients with haematological diseases: Diagnosis through clinical and cytopathological examinations

et al. 2022

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Objective: This study is the first to analyse the prevalence of oral candidiasis in oncohaematological patients by physical and oral cytopathological examinations.Methods: This is a cross-sectional and observational study with a retrospective sample composed of participants hospitalised in the haematology clinic, who were diagnosed with haematological diseases. All participants received an oral mucosal examination and scraping from oral mucosa.Results: Of the 62 participants, 56.5% were male and 82.3% were white, with mean age of 57 years. Lymphoma was the most common haematological disease (24.2%). In total, 48.4% of the sample was diagnosed with oral candidiasis. Of the participants with oral candidiasis, 13 (21.0%) had a clinical diagnosis. Cytopathological analysis revealed 17 more (27.4%) cases without oral lesions indicative of candidiasis. Erythematous candidiasis (P = 0.02), pseudomembranous candidiasis (P < 0.001), clinical candidiasis (P < 0.001), fibrous hyperplasia (P = 0.032), and coated tongue (P = 0.012) showed a correlation with a candidiasis cytopathological diagnosis. Conclusions:Oral candidiasis is common among patients with haematological disease, and the cytopathological examination proved to be a useful tool, confirming clinical diagnosis of candidiasis and identifying subclinical cases. These data are of great relevance considering the possible complications that these patients may develop, such as longer hospitalisations, worsening of the general condition or even death due to candidemia.

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The Effects of Nutraceuticals and Herbal Medicine on Candida albicans in Oral Candidiasis: A Comprehensive Review

Abstract: This version of the chapter has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature's AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections.

Cited by 13 publications

References 87 publications

Berberine suppresses advanced glycation end products‐associated diabetic retinopathy in hyperglycemic mice

Berberine suppresses advanced glycation end products‐associated diabetic retinopathy in hyperglycemic mice

Antibiofilm Activity of Curcumin and Piperine and Their Synergistic Effects with Antifungals against Candida albicans Clinical Isolates

Oral candidiasis in patients with haematological diseases: Diagnosis through clinical and cytopathological examinations

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